Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Richard W. Peluso"'
Publikováno v:
Human Gene Therapy. 20:707-714
A commercial rAAV manufacturing process needs to provide a safe product at high yield, be easily scalable, regulatory-compliant, and have reasonable cost of goods. Considerations for process development include not only product quantity and quality,
Autor:
Alex Mas Monteys, Haim Burstein, Brian L. Gilmore, Barry A. Polisky, Ryan L. Boudreau, Jodi L. McBride, Barrie J. Carter, Richard W. Peluso, Beverly L. Davidson, Scott Q. Harper, Inâs Martins, Patrick D. Staber
Publikováno v:
Proceedings of the National Academy of Sciences. 105:5868-5873
Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. We and others have shown that RNAi is a candidate therapy for HD becau
Autor:
Eric Pastor, Christine Moore, Barbara A. Thorne, Richard W. Peluso, Paulene Quigley, Ryan K. Takeya, David Price, Gina Nichols, Jon W. Ament
Publikováno v:
Biologicals. 36:7-18
Recombinant adeno-associated viral vectors (rAAV) are being developed as gene therapy delivery vehicles and as genetic vaccines, and some of the most scaleable manufacturing methods for rAAV use live adenovirus to induce production. One aspect of est
Autor:
Liang Zhang, Richard W. Peluso, Charles W. Caldwell, Huidong Shi, Keith Munson, Xiaoming Liu, John F. Engelhardt, Barrie J. Carter, Simon Godwin, Christie P. Thomas, Ziying Yan, Christopher J. Gerard, Douglas E. Laux, Joseph Zabner, Phil Karp, Eric Pastor
Publikováno v:
Molecular Therapy. 10:990-1002
Pharmacologic- and gene-based therapies have historically been developed as two independent therapeutic platforms for cystic fibrosis (CF) lung disease. Inhibition of the dysregulated epithelial Na channel (ENaC) is one pharmacologic approach to enha
Autor:
Roman Zak, Wei Ding, Richard W. Peluso, John F. Engelhardt, Yulong Zhang, Simon Godwin, Ziying Yan, Keith Munson
Publikováno v:
Journal of Virology. 78:2863-2874
Tripeptidyl aldehyde proteasome inhibitors have been shown to effectively increase viral capsid ubiquitination and transduction of recombinant adeno-associated virus type 2 (rAAV-2) and rAAV-5 serotypes. In the present study we have characterized a s
Autor:
Richard W. Peluso, Edward J. Bottone
Publikováno v:
Journal of Medical Microbiology. 52:69-74
A compound produced by Bacillus pumilus (MSH) that inhibits Mucoraceae and Aspergillus species is described. Fungicidal activity was demonstrated by lawn-spotting and by diffusion through 0.45 microm Millipore membranes placed on 5 % sheep-blood agar
Autor:
Ana Fernandez-Sesma, Richard W. Peluso, Xu Bai, Jerome L. Schulman, David E. Levy, Thomas M. Moran
Publikováno v:
The Journal of Immunology. 160:1841-1849
A bispecific Ab (BsAb) that binds the TCR on T cells and the G protein of the vesicular stomatitis virus (VSV) can redirect staphylococcal enterotoxin B (SEB)-activated T cells to kill VSV-infected cells and to inhibit VSV replication in vitro. Inhib
Publikováno v:
Virology. 218:335-342
Previous work (C. F. Spiropoulou and S. T. Nichol, 1993,J. Virol.67, 3103–3110) has demonstrated the existence in cells infected with the New Jersey serotype of vesicular stomatitis virus (VSV) of two small carboxy-coterminal proteins encoded by th
Publikováno v:
Virology. 216(2):309-316
The expression of two small basic proteins (C and C*) encoded by a second open reading frame of the New Jersey serotype of vesicular stomatitis virus (VSV) P gene was reported previously (Spiropoulou and Nichol, J. Virol., 67, 3103 – 3110, 1993). H
Autor:
Anne Moscona, Richard W. Peluso
Publikováno v:
Journal of Virology. 67:6463-6468
The ability of enveloped viruses to cause disease depends on their ability to enter the host cell via membrane fusion events. An understanding of these early events in infection, crucial for the design of methods of blocking infection, is needed for