Výsledky vyhledávání - "Richard W. Moyer"

Akademický článek

Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice

Autor: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richard W. Moyer, William L. Clapp, Alexandra R. Lucas

Publikováno v: Journal of Inflammation, Vol 16, Iss 1, Pp 1-9 (2019)

Abstract Background Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem after vessel occlusi

Externí odkaz: https://doaj.org/article/2a583ac6ff0c40f1beb5e17e5a621f77

Zobrazit plný text záznamu

Akademický článek

An Efficient Method for Generating Poxvirus Recombinants in the Absence of Selection

Autor: Stacey A. Gray, Yu Li, Richard W. Moyer, Inger Damon, Amanda D. Rice

Publikováno v: Viruses, Vol 3, Iss 3, Pp 217-232 (2011)

The use of selectable markers (ecogpt) and selection pressures to aid in detection of poxvirus (Vaccinia, VV) recombinants has been implicated in the unintended introduction of second site mutations. We have reinvestigated the use of the helper virus

Externí odkaz: https://doaj.org/article/a629133ef60f45c19461e9e0524dc43c

Zobrazit plný text záznamu

Akademický článek

Efficacy of CMX001 as a Post Exposure Antiviral in New Zealand White Rabbits Infected with Rabbitpox Virus, a Model for Orthopoxvirus Infections of Humans

Autor: Scott Foster, Randall Lanier, Alice Robertson, Richard W. Moyer, George Painter, Bernhard Lampert, Brandi R. Manning, Stacey A. Gray, Daniele Swetnam, Andrew J. Smith, Mathew M. Adams, Greg Wallace, Scott F. Lindsey, Andrew M. Burrage, Amanda D. Rice

Publikováno v: Viruses, Vol 3, Iss 1, Pp 47-62 (2011)

CMX001, a lipophilic nucleotide analog formed by covalently linking 3-(hexdecyloxy)propan-1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. In the absence of human cases of smallpox, new treatments must be tested for efficacy i

Externí odkaz: https://doaj.org/article/bf0ed56610444bce8a4cd6d67495c2a4

Zobrazit plný text záznamu

Akademický článek

Efficacy of CMX001 as a Prophylactic and Presymptomatic Antiviral Agent in New Zealand White Rabbits Infected with Rabbitpox Virus, a Model for Orthopoxvirus Infections of Humans

Autor: Richard W. Moyer, George Painter, Randall Lanier, Amanda D. Rice, Scott Foster, Bernhard Lampert, Mathew M. Adams, Alice Robertson

Publikováno v: Viruses, Vol 3, Iss 2, Pp 63-82 (2011)

CMX001, a lipophilic nucleotide analog formed by covalently linking 3‑(hexdecyloxy)propan-1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. CMX001 has dramatically increased potency versus CDV against all dsDNA viruses and, i

Externí odkaz: https://doaj.org/article/5abde05a4aab44b9a015981bb33c74d5

Zobrazit plný text záznamu

Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice

Autor: Jorge Fuentes, Liqiang Zhang, Hao Chen, Barbara H. Munk, Richard W. Moyer, Lisa R. Dixon, William L. Clapp, Amanda M. Tafoya, Alexandra Lucas, Donghang Zheng, Jennifer Davids, Sriram Ambadapadi, Jordan R. Yaron, Bruno J. Marques, Krishna Harripersaud, Kenneth H. Rand, Dara Wakefield, Mee Y Bartee

Publikováno v: Journal of Inflammation, Vol 16, Iss 1, Pp 1-9 (2019)
Journal of Inflammation (London, England)

Background Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem after vessel occlusion and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d55f3d0f4fde850057f3dc5eea3d246
http://link.springer.com/article/10.1186/s12950-019-0215-1

Zobrazit plný text záznamu

Deriving Immune Modulating Drugs from Viruses—A New Class of Biologics

Autor: Richard W. Moyer, Masmudur M. Rahman, Liqiang Zhang, Jacek M. Kwiecien, Enkidia A. Awo, Qiuyun Guo, Alexandra Lucas, Antonio Alcami, Jordan R. Yaron, Lauren N. Schutz, Michael Juby, Lyn M. Wise, Hao Chen, Kurt L. Krause, Grant McFadden, Michelle Burgin, Cristhian J Ildefonso

Publikováno v: Journal of Clinical Medicine, Vol 9, Iss 972, p 972 (2020)
Journal of Clinical Medicine
Digital.CSIC. Repositorio Institucional del CSIC
instname

Viruses are widely used as a platform for the production of therapeutics. Vaccines containing live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key examples of clinically-approved therapeutic uses for viruses. Despi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ad3775b79bbd572fe5cd4ad78d662
https://www.mdpi.com/2077-0383/9/4/972

Zobrazit plný text záznamu

Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms

Publikováno v: Science China Life Sciences. 57:876-888

Most common SNPs are popularly assumed to be neutral. We here developed novel methods to examine in animal models and humans whether extreme amount of minor alleles (MAs) carried by an individual may represent extreme trait values and common diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9d1ebbc8a211fa6133a221ea13d981
https://doi.org/10.1007/s11427-014-4704-4

Zobrazit plný text záznamu

Protective Properties of Vaccinia Virus-Based Vaccines: Skin Scarification Promotes a Nonspecific Immune Response That Protects against Orthopoxvirus Disease

Autor: Richard W. Moyer, Andrew J. Smith, Amanda D. Rice, Daniele M. Swetnam, Andrew M. Burrage, Mathew M. Adams, Amy L. MacNeill, Scott F. Lindsey, Brandi R. Manning, Greg Wallace

Publikováno v: Journal of Virology. 88:7753-7763

The process of vaccination introduced by Jenner generated immunity against smallpox and ultimately led to the eradication of the disease. Procedurally, in modern times, the virus is introduced into patients via a process called scarification, perform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6ccccd5c84ab296e4f03e1e827beea
https://doi.org/10.1128/jvi.00185-14

Zobrazit plný text záznamu

Viral Anti-Inflammatory Proteins Target Diverging Immune Pathways with Converging Effects on Arterial Dilatation, Plaque and Apoptosis

Autor: Richard W. Moyer, Hao Chen, Alexandra Lucas, Erbin Dai, Adisson Fortunel, Jennifer Davids, Li Ying Liu, Grant McFadden, Mee Y Bartee

Publikováno v: European Journal of Inflammation, Vol 12 (2014)

Abdominal aortic aneurysms are often fatal due to atherosclerosis, thromboembolism, rupture, and hemorrhage, however, treatment is limited to expectant monitoring and surgical intervention. Inflammation is detected in aneurysms and in plaque with ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3041f72cab377f3097d28adbe0123f
https://doi.org/10.1177/1721727x1401200113

Zobrazit plný text záznamu

The Serpin Solution; Targeting Thrombotic and Thrombolytic Serine Proteases in Inflammation

Autor: Erik A.L. Biessen, Lakshmyya Kesavalu, Richard W. Moyer, Donghang Zheng, Alexandra Lucas, Kate D. Ryman, Ilze Bot, Marsha Bryant, Theo J.C. van Berckel, Carl J. Pepine, Jennifer Davids, Hao Chen, Grant McFadden, Ann Progulski-Fox

Publikováno v: Cardiovascular & Hematological Disorders-Drug Targets. 13:99-110

Serpins in the mammalian body are highly potent serine protease inhibitors which modulate both thrombotic and thrombolytic pathway activation, with direct and indirect crosstalk with immune and inflammatory pathways. In this review, we discuss mammal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2356b9a1c3b35f76e8a0a334169539
https://doi.org/10.2174/1871529x11313020003

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání