Výsledky vyhledávání - "Richard W. Fries"

3-Substituted pyrazole derivatives as inhibitors and inactivators of liver alcohol dehydrogenase

Autor: Bryce V. Plapp, David P. Bohlken, Richard W. Fries

Publikováno v: Journal of Medicinal Chemistry. 22:356-359

3-Substituted pyrazoles, HOCH2 (1), HOCH2CH2 (2), HOCH2CH2CH2 (3), ClCH2 (4), ClCH2CH2 (5), ClCH2CH2CH2 (6), and CH3CO (7), were synthesized and evaluated in vitro on horse liver alcohol dehydrogenase for their potential as inhibitors of ethanol meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2838269d2a19f1e0034feb7b61ca96fe
https://doi.org/10.1021/jm00190a005

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Sulfonate analogs of adenosine nucleotides as inhibitors of nucleotide-binding enzymes

Autor: Richard W. Fries, Bryce V. Plapp, Christoph Woenckhaus, Paul H. C. Mundill

Publikováno v: Journal of Medicinal Chemistry. 24:474-477

2-(Adenin-9-yl)ethanesulfonic acid (1), 3-(adenin-9-yl)propanesulfonic acid (2), 9-(5-deoxy-beta-D-ribofuranosyl)-adenine-5'-sulfonic acid (3), and 9-(3-deoxy-beta-D-arabinofuranosyl)adenine-3'-sulfonic acid (4) were prepared by reaction of the corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34ec2e20f51ef54fbe07be0f7e31e69
https://doi.org/10.1021/jm00136a021

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omega-haloalkyl esters of 5'-adenosine monophosphate as potential active-site-directed reagents for dehydrogenases

Autor: Kevin G. Leidal, Bryce V. Plapp, David P. Bohlken, Bruce P. Murch, Richard W. Fries

Publikováno v: Archives of biochemistry and biophysics. 225(1)

A series of esters of adenosine 5′-monophosphate with ethyl, propyl, or hexyl moieties substituted at the ω-position with chlorine or bromine were prepared. The compounds were competitive inhibitors of horse liver alcohol dehydrogenase with respec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7c2e8e7100dddd07d856a16320f6c5
https://pubmed.ncbi.nlm.nih.gov/6351750

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Activation of liver alcohol dehydrogenases by imidoesters generated in solution

Autor: Bryce V. Plapp, David P. Bohlken, Richard W. Fries, Robin T. Blakley

Publikováno v: Biochemistry. 14(23)

Various omega-halogenated carboxy acids and amides were evaluated as potential active-site-directed reagents for alcohol dehydrogenase. 2-Bromoacetamide and bromoacetic and 3-bromopropionic acids inactivated the enzyme; AMP, NAD+, and NADH markedly d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98873051731985a7181dda44b7ea064c
https://pubmed.ncbi.nlm.nih.gov/172120

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ChemInform Abstract: SULFONATE ANALOGS OF ADENOSINE NUCLEOTIDES AS INHIBITORS OF NUCLEOTIDE-BINDING ENZYMES

Autor: P. H. C. Mundill, Richard W. Fries, Christoph Woenckhaus, Bryce V. Plapp

Publikováno v: Chemischer Informationsdienst. 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3f127b3a35ae0eb1322191664cd9b15
https://doi.org/10.1002/chin.198135334

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ChemInform Abstract: 3-SUBSTITUTED PYRAZOLE DERIVATIVES AS INHIBITORS AND INACTIVATORS OF LIVER ALCOHOL DEHYDROGENASE

Autor: Bryce V. Plapp, David P. Bohlken, Richard W. Fries

Publikováno v: Chemischer Informationsdienst. 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82151e9f1c2e23dd2caef7d34f6915a4
https://doi.org/10.1002/chin.197933202

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