Výsledky vyhledávání - "Richard W. Fitch"

Akademický článek

Targeting the OB-Folds of Replication Protein A with Small Molecules

Autor: Victor J. Anciano Granadillo, Jennifer N. Earley, Sarah C. Shuck, Millie M. Georgiadis, Richard W. Fitch, John J. Turchi

Publikováno v: Journal of Nucleic Acids, Vol 2010 (2010)

Replication protein A (RPA) is the main eukaryotic single-strand (ss) DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs) that show in vitro inhibition of the RP

Externí odkaz: https://doaj.org/article/105fba2e831342b5a65de6130732dac8

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Trade-offs between cost of ingestion and rate of intake drive defensive toxin use

Autor: Tyler E. Douglas, Sofia G. Beskid, Callie E. Gernand, Brianna E. Nirtaut, Kristen E. Tamsil, Richard W. Fitch, Rebecca D. Tarvin

Publikováno v: Biol Lett

Animals that ingest toxins can become unpalatable and even toxic to predators and parasites through toxin sequestration. Because most animals rapidly eliminate toxins to survive their ingestion, it is unclear how populations transition from susceptib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b482f5d9903ccb69042f84d41dafcbc
https://pubmed.ncbi.nlm.nih.gov/35135316

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Trade-offs between cost of ingestion and rate of intake drive defensive toxin use

Autor: Kristen E. Tamsil, Sofia G. Beskid, Tyler E. Douglas, Rebecca D. Tarvin, Brianna E. Nirtaut, Callie E. Gernand, Richard W. Fitch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0333d21e172bab7f3baa7c5e073d83c5
https://doi.org/10.1101/2021.07.23.453507

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Cross-Course Collaboration in the Undergraduate Chemistry Curriculum: Primary Kinetic Isotope Effect in the Hypochlorite Oxidation of 1-Phenylethanol in the Physical Chemistry Laboratory

Autor: Richard A. Wyatt, Richard A. Kjonaas, Richard W. Fitch, Robert J. Noll

Publikováno v: Journal of Chemical Education. 94:1338-1342

A kinetic isotope effect (KIE) experiment is described for the physical chemistry laboratory. Students conduct a hypochlorite (household bleach) oxidation of an equimolar mixture of 1-phenylethanol and 1-deuterio-1-phenylethanol to acetophenone. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0da94caf67be501a2137ba892d0db6e3
https://doi.org/10.1021/acs.jchemed.6b00950

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Cross-Course Collaboration in the Undergraduate Chemistry Curriculum: Isotopic Labeling with Sodium Borodeuteride in the Introductory Organic Chemistry Laboratory

Autor: Richard A. Kjonaas, Robert J. Noll, Richard W. Fitch

Publikováno v: Journal of Chemical Education. 94:1334-1337

A microscale isotopic labeling experiment is described for the introductory organic chemistry laboratory course wherein half of the students use sodium borohydride (NaBH4) and the other half use sodium borodeuteride (NaBD4) to reduce acetophenone to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37ead8a71579d1ef542b281c0cda99a1
https://doi.org/10.1021/acs.jchemed.6b00949

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Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin

Autor: Diane Bodenmiller, Tracy M. Neher, Richard W. Fitch, John J. Turchi, Shadia I. Jalal

Publikováno v: Molecular Cancer Therapeutics. 10:1796-1806

Replication protein A (RPA) is a single-strand DNA-binding protein with essential roles in DNA replication, recombination, and repair. It is necessary for the formation of the preincision complex that is required for proper incision of damaged DNA nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865cb54e7f461a7da2ac82ad8f19305
https://doi.org/10.1158/1535-7163.mct-11-0303

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