Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Richard W. Erickson"'
Autor:
Vaishalee A. Padgaonkar, Peter A. Ward, Richard W. Erickson, John T. Curnutte, J. Vidya Sarma, Markus Huber-Lang, Kristina T. Lu, Ellen M. Younkin, Stephanie R. McGuire, Ren Feng Guo
Publikováno v:
The Journal of Immunology. 169:3223-3231
This study defines the molecular basis for defects in innate immunity involving neutrophils during cecal ligation/puncture (CLP)-induced sepsis in rats. Blood neutrophils from CLP rats demonstrated defective phagocytosis and defective assembly of NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a6f067339e00d3ddbb842a9b9d5d8e
https://doi.org/10.4049/jimmunol.169.6.3223
https://doi.org/10.4049/jimmunol.169.6.3223
Autor:
Richard W. Erickson, Paul G. Heyworth, John T. Curnutte, Alexis Traynor-Kaplan, Paola Langel-Peveri
Publikováno v:
Journal of Biological Chemistry. 274:22243-22250
The superoxide-generating neutrophil NADPH oxidase can be activated in cell-free reconstitution systems by several agonists, most notably arachidonic acid and the detergent sodium dodecyl sulfate. In this study, we show that both phosphatidic acids a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d339e4acd3b2fc2699c2bcb676b56e5
https://doi.org/10.1074/jbc.274.32.22243
https://doi.org/10.1074/jbc.274.32.22243
Publikováno v:
Biochemical Journal. 341:251-255
It is commonly assumed that activation of the superoxide-generating NADPH oxidase requires the formation of a stable complex between flavocytochrome b-245 (the gp91phox/p22phox heterodimer) and the cytosolic cofactors p47phox, p67phox and Rac2. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a18f76a8d5970bf3face849a2c7e235
https://doi.org/10.1042/bj3410251
https://doi.org/10.1042/bj3410251
Publikováno v:
Journal of Biological Chemistry. 274:15519-15525
We have examined the kinetics of NADPH oxidase activation induced by arachidonic acid or SDS in a cell-free system using mixtures of recombinant Phox proteins and purified flavocytochrome b −245. Activation of oxidase activity required the simultan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dcdfd7bdf6bc2b22d24b044e85d8684
https://doi.org/10.1074/jbc.274.22.15519
https://doi.org/10.1074/jbc.274.22.15519
Publikováno v:
Biochemical Journal. 338:229-233
The role of magnesium ions in the activation of NADPH oxidase has been investigated using flavocytochrome b-245 and either neutrophil cytosol or mixtures of recombinant p40phox, p47phox, p67phox and Rac2. Purified flavocytochrome b-245 is highly acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06339a4594b2bca40239fd850e2870ee
https://doi.org/10.1042/bj3380229
https://doi.org/10.1042/bj3380229
Autor:
Richard W. Erickson, Jiabing Ding, John A. Badwey, Paul G. Heyworth, Diane J. Lu, John T. Curnutte
Publikováno v:
Blood. 87:4404-4410
Neutrophils are known to contain a major 67-kD protein that undergoes enhanced phosphorylation and translocation to the membrane during cell stimulation. Recent studies have assumed that this 67-kD phosphoprotein is the 67-kD subunit of the phagocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bbec1364c38ea6373e0b9042f98b133
https://doi.org/10.1182/blood.v87.10.4404.bloodjournal87104404
https://doi.org/10.1182/blood.v87.10.4404.bloodjournal87104404
Autor:
Peter E. Newburger, Pervin Anklesaria, Richard C. Woodman, John T. Curnutte, Julie Rae, Myron S. Cohen, Richard W. Erickson
Publikováno v:
Blood. 85:231-241
Chronic granulomatous disease (CGD) is characterized by recurrent infections, and is usually associated with a complete inability of phagocytic cells to generate superoxide anion (O2-). Rarely, variant forms of CGD have been reported in which there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de5bd1a43c3dba7a960090ea0092e6a1
https://doi.org/10.1182/blood.v85.1.231.bloodjournal851231
https://doi.org/10.1182/blood.v85.1.231.bloodjournal851231
Publikováno v:
Journal of Biological Chemistry. 269:10813-10819
The 47-kDa subunit of the NADPH oxidase system (p47-phox) of neutrophils undergoes an association with proteins in the Triton X-100-insoluble fraction upon stimulation of the cells with 4 beta-phorbol 12-myristate 13-acetate. This fraction contains t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8304d6aa184b719ef06b9ff89610614
https://doi.org/10.1016/s0021-9258(17)34132-7
https://doi.org/10.1016/s0021-9258(17)34132-7
Autor:
Owen D. Solberg, Guiquan Jia, Richard Carter, Richard W. Erickson, Prescott G. Woodruff, John V. Fahy, David F. Choy, Jeffrey M. Harris, Peter Bradding, Qutayba Hamid, Joseph R. Arron, Sofia Mosesova, Severine Audusseau, Aarti Shikotra
Publikováno v:
C38. AIRWAY INFLAMMATION: FROM MECHANISMS TO NON-INVASIVE BIOMARKERS.
Background: Eosinophilic airway inflammation is heterogeneous in asthma. We recently described a distinct subtype of asthma defined by the expression of genes inducible by Th2 cytokines in bronchial epithelium. This gene signature, which includes per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76bfc0e706aa5aa585a5e20f31d0cc45
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4455
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4455
Publikováno v:
Blood. 82:940-947
A procedure for uncovering novel protein kinases was used to search for enzymes in neutrophils that may catalyze the phosphorylation of the 47- Kd subunit of the NADPH oxidase system (p47-phox). This component of the oxidase can undergo phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a4a4a27fb2457837893fc868f7ba873
https://doi.org/10.1182/blood.v82.3.940.940
https://doi.org/10.1182/blood.v82.3.940.940