Výsledky vyhledávání - "Richard W. E. Clarkson"

Akademický článek

Suppression of Bcl3 Disrupts Viability of Breast Cancer Cells through Both p53-Dependent and p53-Independent Mechanisms via Loss of NF-κB Signalling

Autor: Daniel J. Turnham, Hannah Smith, Richard W. E. Clarkson

Publikováno v: Biomedicines, Vol 12, Iss 1, p 143 (2024)

The NF-κB co-factor Bcl3 is a proto-oncogene that promotes breast cancer proliferation, metastasis and therapeutic resistance, yet its role in breast cancer cell survival is unclear. Here, we sought to determine the effect of Bcl3 suppression alone

Externí odkaz: https://doaj.org/article/12c99a270ee542e280d4834f10005bc2

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Akademický článek

Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5NULL-A20

Autor: James A. Davies, Gareth Marlow, Hanni K. Uusi-Kerttula, Gillian Seaton, Luke Piggott, Luned M. Badder, Richard W. E. Clarkson, John D. Chester, Alan L. Parker

Publikováno v: Viruses, Vol 13, Iss 5, p 864 (2021)

We previously developed a refined, tumor-selective adenovirus, Ad5NULL-A20, harboring tropism ablating mutations in each major capsid protein, to ablate all native means of infection. We incorporated a 20-mer peptide (A20) in the fiber knob for selec

Externí odkaz: https://doaj.org/article/0de1c5c44a1c4abe94c824c0b12e335e

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