Výsledky vyhledávání - "Richard W. Doughty"

Splenic marginal zone lymphoma in a European harvest mouse (Micromys minutus)

Autor: Jackie Bowman, Richard W. Doughty, Clare Lightbody

Publikováno v: Comparative Clinical Pathology. 15:263-266

A splenic marginal zone lymphoma was diagnosed in a female European harvest mouse (Micromys minutus) that presented clinically with poor body condition and abdominal swelling. On palpation, a mass in the cranial abdomen was identified. The owner elec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e8fce75b3c93b247ba1d09956f6d567
https://doi.org/10.1007/s00580-006-0639-x

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A modified model of gentamicin induced renal failure in rats: toxicological effects of the iodinated X-ray contrast media ioversol and potential usefulness for toxicological evaluation of iodinated X-ray contrast media

Autor: Oddvar Myhre, Hanne Jensen, Derek Grant, Richard W. Doughty

Publikováno v: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 65(5)

Contrast-induced nephropathy (CIN) remains a serious complication in patients exposed to iodinated X-ray contrast media (ICM). Animal models of CIN are useful to further understand the mechanisms involved, identify novel biomarkers and evaluate poten

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https://pubmed.ncbi.nlm.nih.gov/22727913

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The effects of the iodinated X-ray contrast media iodixanol, iohexol, iopromide, and ioversol on the rat kidney epithelial cell line NRK 52-E

Autor: Derek Grant, Richard W. Doughty, Oddvar Myhre, Hanne Jensen

Publikováno v: Renal failure. 33(4)

Nephrotoxicity, associated with the administration of iodinated X-ray contrast media (ICM), continues to be a major side effect in a significant number of vulnerable patients undergoing diagnostic X-ray imaging procedures. The molecular mechanisms un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4912458fe2c271db2c5eb99e5cf6c818
https://pubmed.ncbi.nlm.nih.gov/21529272

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Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants

Autor: Christina Rada, Leonardo A. Meza-Zepeda, Gaute Nesse, Jon K. Laerdahl, Liv Kleppa, Arne Klungland, Richard W. Doughty, Cesilie G. Castellanos, Michael S. Neuberger, Trine J. Meza, Elisabeth Larsen, Guro Flor Lien

Publikováno v: Cancer research. 68(12)

Flap endonuclease 1 (FEN1) processes Okazaki fragments in lagging strand DNA synthesis, and FEN1 is involved in several DNA repair pathways. The interaction of FEN1 with the proliferating cell nuclear antigen (PCNA) processivity factor is central to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b244070d6103bbe01ef949f3794235
https://pubmed.ncbi.nlm.nih.gov/18559501

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Iodixanol 320 results in better renal tolerance and radiodensity than do gadolinium-based contrast media: arteriography in ischemic porcine kidneys

Autor: Peter Leander, Chun-Ming Chai, Torsten Almén, Rikard Pehrson, Jonas Björk, Klaes Golman, Derek Grant, Richard W. Doughty, Ulf Nyman, Barbara Elmståhl

Publikováno v: Radiology. 247(1)

To prospectively compare nephrotoxicity and radiodensity of plasma hyperosmotic gadolinium chelates (attenuation-osmotic ratio of 1:1) with those of plasma iso-osmotic iodine-based contrast media (attenuation-osmotic ratio of 3:1 or 6:1) after renal

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https://pubmed.ncbi.nlm.nih.gov/18292474

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Histomorphological changes after renal X-ray arteriography using iodine and gadolinium contrast media in an ischemic porcine model

Autor: Peter Leander, Torsten Almén, Ulf Nyman, Barbara Elmståhl, Jonas Björk, Chun-Ming Chai, Derek Grant, Richard W. Doughty

Publikováno v: Acta radiologica (Stockholm, Sweden : 1987). 48(10)

Background: Gadolinium contrast media (Gd-CM) are regarded as non-nephrotoxic or considerably less nephrotoxic than iodine contrast media (I-CM), and have therefore come to be used as a substitute for I-CM in patients with renal insufficiency in a va

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https://pubmed.ncbi.nlm.nih.gov/17963073

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Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

Autor: Vivi Talstad, Hans E. Krokan, Line M. Nordstrand, Jeanette Ringvoll, Nina-Beate Liabakk, Knut H. Lauritzen, Alexandra Bjørk, Per Arne Aas, Richard W. Doughty, Karen Reite, Arne Klungland, Cathrine Broberg Vågbø, Pål Ø. Falnes

Publikováno v: The EMBO journal. 25(10)

Two human homologs of the Escherichia coli AlkB protein, denoted hABH2 and hABH3, were recently shown to directly reverse 1-methyladenine (1meA) and 3-methylcytosine (3meC) damages in DNA. We demonstrate that mice lacking functional mABH2 or mABH3 ge

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https://pubmed.ncbi.nlm.nih.gov/16642038

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