Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Richard W. Deibler"'
Autor:
Stewart L. Fisher, Marta Isasa, Stephen Archer, Heng Li, Mark E. Fitzgerald, Lydia Emerson, Christopher G. Nasveschuk, Linda Lee, Roman V. Agafonov, Richard W. Deibler, Jeffrey R Simard, Ryan E. Michael, Ellen F. Vieux, Brendon Ladd, David A. Proia, Gunther Kern, Eunice S. Park, Andrew J. K. Phillips, David Cocozziello
Publikováno v:
SLAS Discovery. 26:547-559
Recent advances in targeted protein degradation have enabled chemical hijacking of the ubiquitin-proteasome system to treat disease. The catalytic rate of cereblon (CRBN)-dependent bifunctional degradation activating compounds (BiDAC), which recruit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b95d7f93321f5de660b39ea7553ea25
https://doi.org/10.1177/24725552211000673
https://doi.org/10.1177/24725552211000673
Autor:
Joe Sahil Patel, Eunice S. Park, Chi-Li Chen, Andrew J. K. Phillips, Linda Lee, Thomas G. Scott, Christina S. Henderson, Ashley A. Hart, David A. Proia, James A. Henderson, W. Austin Elam, Catherine S. Oakes, Trang N. Tieu, Joelle Baddour, Mark C. Norley, Mathew E. Sowa, Jessica Freda, Marius S. Pop, Brendon Ladd, Minsheng He, Christopher G. Nasveschuk, Harit U. Vora, Gunther Kern, Gesine Kerstin Veits, Abigail Vogelaar, Stewart L. Fisher, Richard W. Deibler, Rhamy Zeid, Mark W. Carlson, Roman V. Agafonov, Arushi Jain, Graham P. Marsh, Prasoon Chaturvedi, Hannah J. Maple, Scott J. Eron, Emily S. Kibbler
Publikováno v:
Current Research in Chemical Biology, Vol 1, Iss, Pp 100010-(2021)
In addition to the therapeutic applicability of targeted protein degradation (TPD), the modality also harbors unique properties that enable the development of innovative chemical biology tools to interrogate complex biology. TPD offers an all-chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fae8825e77dd3f8f25ec2a5b2702cc
http://www.sciencedirect.com/science/article/pii/S2666246921000100
http://www.sciencedirect.com/science/article/pii/S2666246921000100
Autor:
Garrett C. Heffner, Richard W. Deibler, Patrick Cahan, Rui Zhao, Juli Unternaehrer, Marc W. Kirschner, Andrea Ballabeni, George Q. Daley, Paul H. Lerou
Publikováno v:
Proceedings of the National Academy of Sciences. 111:15768-15773
Rapid progression through the cell cycle and a very short G1 phase are defining characteristics of embryonic stem cells. This distinct cell cycle is driven by a positive feedback loop involving Rb inactivation and reduced oscillations of cyclins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035d0f2bcae21533358073ade5aa9d57
https://doi.org/10.1073/pnas.1417518111
https://doi.org/10.1073/pnas.1417518111
Autor:
Richard W. Deibler, Gary S. McDowell, Marc W. Kirschner, Fahad R. Ali, François Guillemot, Christopher J. Hindley, Anna Philpott, Alison Jones
Publikováno v:
Development. 138:4267-4277
During development of the central nervous system, the transition from progenitor maintenance to differentiation is directly triggered by a lengthening of the cell cycle that occurs as development progresses. However, the mechanistic basis of this reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5379ea509d1d21e8975cb507fba863
https://doi.org/10.1242/dev.067900
https://doi.org/10.1242/dev.067900
Publikováno v:
Nucleic Acids Research
The nucleotide sequence of DNA is the repository of hereditary information. Yet, it is now clear that the DNA itself plays an active role in regulating the ability of the cell to extract its information. Basic biological processes, including control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1377a987f4ce8c93ae196dee6c975e83
https://doi.org/10.1093/nar/gkp041
https://doi.org/10.1093/nar/gkp041
Autor:
Russell J. DiGate, P. J. Hastings, Richard W. Deibler, Jeanine M. Pennington, Christopher R. Lopez, Starlight A. Ray, Shirley Yang, Susan M. Rosenberg, Lynn Zechiedrich
Publikováno v:
Molecular Microbiology. 58:80-101
The physiological role of topoisomerase III is unclear for any organism. We show here that the removal of topoisomerase III in temperature sensitive topoisomerase IV mutants in Escherichia coli results in inviability at the permissive temperature. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e05156bcbd512ecd8c0cd7ff9aaebe95
https://doi.org/10.1111/j.1365-2958.2005.04812.x
https://doi.org/10.1111/j.1365-2958.2005.04812.x
Publikováno v:
Biology of Reproduction. 59:358-363
Laboratory rats generally do not respond reproductively to short days (SD) unless they are given treatments that unmask reproductive inhibition in SD. While young Fischer 344 (F344) rats are unusual among rat strains in that SD substantially inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe8812b8d3fd1b6171f9ded18c96250
https://doi.org/10.1095/biolreprod59.2.358
https://doi.org/10.1095/biolreprod59.2.358
Autor:
Marc W. Kirschner, Richard W. Deibler
Publikováno v:
Molecular cell. 37(6)
Summary The regulation of mitotic entry in somatic cells differs from embryonic cells, yet it is only for embryonic cells that we have a quantitative understanding of this process. To gain a similar insight into somatic cells, we developed a human ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773ebfe728c7f014bf7266360dbf8d9f
https://pubmed.ncbi.nlm.nih.gov/20347419
https://pubmed.ncbi.nlm.nih.gov/20347419
Publikováno v:
BMC Molecular Biology, Vol 8, Iss 1, p 44 (2007)
BMC Molecular Biology
BMC Molecular Biology
Background The genetic code imposes a dilemma for cells. The DNA must be long enough to encode for the complexity of an organism, yet thin and flexible enough to fit within the cell. The combination of these properties greatly favors DNA collisions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811cd09be723dd8fce4121bb8ec0a900
https://doi.org/10.1186/1471-2199-8-44
https://doi.org/10.1186/1471-2199-8-44
Autor:
Christopher R, Lopez, Shirley, Yang, Richard W, Deibler, Starlight A, Ray, Jeanine M, Pennington, Russell J, Digate, P J, Hastings, Susan M, Rosenberg, E Lynn, Zechiedrich
Publikováno v:
Molecular microbiology. 58(1)
The physiological role of topoisomerase III is unclear for any organism. We show here that the removal of topoisomerase III in temperature sensitive topoisomerase IV mutants in Escherichia coli results in inviability at the permissive temperature. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39e41df14d4b199ab7cb9d6e45404f7d
https://pubmed.ncbi.nlm.nih.gov/16164551
https://pubmed.ncbi.nlm.nih.gov/16164551