Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Richard W. Chapman"'
Autor:
Richard W. Chapman, Michel R. Corboz, Carlos Fernandez, Eugene Sullivan, Andy Stautberg, Adam J. Plaunt, Donna M. Konicek, Vladimir Malinin, Zhili Li, David Cipolla, Walter Perkins
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Cough is induced by inhaled prostacyclin analogues including treprostinil (TRE), and, at higher doses, treprostinil palmitil (TP), a prodrug of TRE. In this report, we have investigated mechanisms involved in TRE- and TP-induced cough, using a dry po
Externí odkaz:
https://doaj.org/article/190cdcb737b843978c4edc4c3898f89d
Autor:
Adam J. Plaunt, Sadikul Islam, Tony Macaluso, Helena Gauani, Thomas Baker, Donald Chun, Veronica Viramontes, Christina Chang, Michel R. Corboz, Richard W. Chapman, Zhili Li, David C. Cipolla, Walter R. Perkins, Vladimir S. Malinin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 548 (2021)
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the lungs with reduced systemic exposure an
Externí odkaz:
https://doaj.org/article/4c4d58c1a0184939b9ca33128da7d82b
Autor:
Adam J. Plaunt, Sasha J. Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala, Ryan P. Heckler, Arielle Dorfman, Barrett T. Smith, Donald Chun, Veronica Viramontes, Antonio Macaluso, Zhili Li, Yuchen Zhou, Lilly Mark, Jessica Basso, Franziska G. Leifer, Michel R. Corboz, Richard W. Chapman, David Cipolla, Walter R. Perkins, Vladimir S. Malinin, Donna M. Konicek
Publikováno v:
Antimicrob Agents Chemother
Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic fibrosis (CF) has a high probability of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated with reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7982c69e91dbbdd3bc2a38062e4560
https://europepmc.org/articles/PMC9664855/
https://europepmc.org/articles/PMC9664855/
Autor:
Walter Perkins, Richard W. Chapman, Vladimir Malinin, Michel R. Corboz, Eugene J. Sullivan, Zhili Li, David Cipolla, Adam J. Plaunt, Andy Stautberg, Donna M. Konicek, Carlos Fernandez
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
Cough is induced by inhaled prostacyclin analogues including treprostinil (TRE), and, at higher doses, treprostinil palmitil (TP), a prodrug of TRE. In this report, we have investigated mechanisms involved in TRE- and TP-induced cough, using a dry po
Autor:
Michel R. Corboz, Adam J. Plaunt, Vladimir S. Malinin, Zhili Li, Helena Gauani, Donald Chun, David Cipolla, Walter R. Perkins, Richard W. Chapman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 383(1)
Treprostinil palmitil (TP), a long-acting inhaled pulmonary vasodilator prodrug of treprostinil (TRE), has beneficial effects in a Sugen5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) that compare favorably to the oral phospho
Autor:
David Cipolla, Jessica Basso, Donald Chun, Lilly Mark, Vladimir Malinin, Richard W. Chapman, Daniel LaSala, Sasha J. Rose, Barrett T Smith, Zhili Li, Michel R. Corboz, Ryan P Heckler, Arielle Dorfman, Adam J. Plaunt, Yuchen Zhou, Jeong Yeon Kang, Veronica Viramontes, Antonio Macaluso, Kuan-Ju Chen, Walter Perkins, Donna M. Konicek, Franziska Leifer
Publikováno v:
Antimicrobial Agents and Chemotherapy
Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic fibrosis (CF) has a high probability of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated with reduc
Autor:
Richard W. Chapman, Walter Perkins, Tony Macaluso, Donald Chun, Vladimir Malinin, Zhili Li, Helena Gauani, Sadikul Islam, David Cipolla, Veronica Viramontes, Adam J. Plaunt, Michel R. Corboz, Thomas Baker, Christina Chang
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 548, p 548 (2021)
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 548, p 548 (2021)
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the lungs with reduced systemic exposure an
Autor:
Richard W. Chapman, Donna M. Konicek, Adam J. Plaunt, Zhili Li, Walter Perkins, Vladimir Malinin, Michel R. Corboz
Publikováno v:
Pulmonary pharmacologytherapeutics. 65
Treprostinil (TRE) is a prostanoid analog pulmonary vasodilator drug marketed with subcutaneous, intravenous (i.v.), oral, and inhaled routes of administration for the treatment of pulmonary arterial hypertension (PAH). Due to its short half-life, TR
Autor:
Richard W. Chapman, Zhili Li, Helena Gauani, Charles E. Laurent, Michel R. Corboz, Walter Perkins, C Brodeur, Vladmir Malinin, Adam J. Plaunt, Donald Chun, Sandra Gagnon, David Cipolla
Publikováno v:
Pulmonary hypertension.
Introduction: Sugen/Hypoxia (Su/Hx) challenge to rats produces many pathophysiological markers of human pulmonary arterial hypertension (PAH). Aim: Compare the effects of TPIS, a long-acting prodrug of treprostinil (TRE) and the PDE5 inhibitor Sild o
Autor:
David Cipolla, Richard W. Chapman, C Brodeur, Dany Salvail, Annie Bouchard, Charles E. Laurent, Michel R. Corboz, Sandra Gagnon, Walter Perkins
Publikováno v:
Pulmonary hypertension.
Introduction: The sugen/hypoxia (SuHx) rat model of pulmonary arterial hypertension (PAH) replicates much of the pathology seen in the clinical disease. Aim: To determine the severity of the pulmonary vascular hemodynamics, vascular remodeling and in