Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Richard W. Carr"'
Autor:
Robin Jonas, Vincenzo Prato, Stefan G. Lechner, Gerbrand Groen, Otilia Obreja, Fiona Werland, Roman Rukwied, Andreas Klusch, Marlen Petersen, Richard W. Carr, Martin Schmelz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX
Externí odkaz:
https://doaj.org/article/940d087a68b74902b0e07b9c69eb24d5
Autor:
Veronica Bonalume, Lucia Caffino, Luca F. Castelnovo, Alessandro Faroni, Flavio Giavarini, Sheng Liu, Donatella Caruso, Martin Schmelz, Fabio Fumagalli, Richard W. Carr, Valerio Magnaghi
Publikováno v:
Cells, Vol 9, Iss 8, p 1874 (2020)
Protein kinase type C-ε (PKCε) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification. In these neurons, PKCε is modula
Externí odkaz:
https://doaj.org/article/1d284891f77447e194d2cc8e7fe9df75
Autor:
Margot Maurer, Nunzia Papotto, Julika Sertel-Nakajima, Markus Schueler, Roberto De Col, Frank Möhrlen, Karl Messlinger, Stephan Frings, Richard W Carr
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0211175 (2019)
Olfactory and trigeminal chemosensory systems reside in parallel within the mammalian nose. Psychophysical studies in people indicate that these two systems interact at a perceptual level. Trigeminal sensations of pungency mask odour perception, whil
Externí odkaz:
https://doaj.org/article/7684c42985a943e0af043252fdb0df04
Autor:
Veronica Bonalume, Lucia Caffino, Jing Hu, Giambattista Bonanno, Kyra Sohns, Richard W. Carr, Luca Franco Castelnovo, Fabio Fumagalli, Martin Schmelz, Roberto De Col, Marco Milanese, Valerio Magnaghi, Sheng Liu, Tal Hoffmann, Alessandro Faroni
Publikováno v:
The Journal of Physiology. 599:4065-4084
KEY POINTS GABA depolarized sural nerve axons and increased the electrical excitability of C-fibres via GABAA receptor. Axonal excitability responses to GABA increased monotonically with the rate of action potential firing. Action potential activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b997c5746281b0aa5a5a3aab3d4446
https://doi.org/10.1113/jp279664
https://doi.org/10.1113/jp279664
Autor:
Sabrina Soares, Roman Rukwied, Richard W. Carr, Mark Schnakenberg, Barbara Namer, Julius Pakalniskis, Martin Schmelz, Robin Jonas
Publikováno v:
European Journal of Pain. 24:122-133
BACKGROUND Sinusoidal current stimuli preferentially activate C-nociceptors. Sodium channel isoforms NaV1.7 and NaV1.8 have been implicated in this. Sympathetic efferent neurons lack NaV1.8 and were explored upon sinusoidal activation. METHODS Quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e0b6c344adff4e67b7a948bbbfd5c6
https://doi.org/10.1002/ejp.1467
https://doi.org/10.1002/ejp.1467
Autor:
Flavio Giavarini, Lucia Caffino, Veronica Bonalume, Martin Schmelz, Richard W. Carr, Sheng Liu, Alessandro Faroni, Fabio Fumagalli, Donatella Caruso, Valerio Magnaghi, Luca Franco Castelnovo
Publikováno v:
Cells, Vol 9, Iss 1874, p 1874 (2020)
Cells
Volume 9
Issue 8
Cells
Volume 9
Issue 8
Protein kinase type C-&epsilon
(PKC&epsilon
) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification. In these n
(PKC&epsilon
) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification. In these n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd00dfc85db44130c926cacdcd3a7904
https://www.mdpi.com/2073-4409/9/8/1874
https://www.mdpi.com/2073-4409/9/8/1874
Autor:
Ellen Jørum, Richard W. Carr, Otilia Obreja, Roman Rukwied, Martin Schmelz, Barbara Namer, Inge Petter Kleggetveit, Christian Thomas, Fiona Werland
Publikováno v:
Pain. 161(9)
High-threshold mechanosensitive and mechanoinsensitive ("silent") nociceptors have similar electrical thresholds for transcutaneous sine wave stimulation at 4 Hz that selectively activates cutaneous C nociceptors in human skin. Their fundamentally di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564cb28c9a290f953a65ef4f4982fa5a
https://pubmed.ncbi.nlm.nih.gov/32379219
https://pubmed.ncbi.nlm.nih.gov/32379219
Autor:
Alina Vyshnevska, Christian Weidner, Jürgen Wittmann, Peter W. Reeh, Ohad Sharon, Roberto De Col, Mohammed A. Nassar, Richard W. Carr, Tal Hoffmann
Publikováno v:
Pain. 159:496-506
The sodium channel NaV1.7 contributes to action potential (AP) generation and propagation. Loss-of-function mutations in patients lead to congenital indifference to pain, though it remains unclear where on the way from sensory terminals to central ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c793db0662c07a1cb28a42db0874f9c
https://doi.org/10.1097/j.pain.0000000000001119
https://doi.org/10.1097/j.pain.0000000000001119
Autor:
Amanda H. Klein, Roberto De Col, Martin Schmelz, Alina Vyshnevska, Richard W. Carr, Frank Bosmans, Timothy V. Hartke, Peter W. Reeh, Brian Turnquist, Matthias Ringkamp, Joseph L. Mankowski
Publikováno v:
The Journal of Neuroscience. 37:5204-5214
Voltage-gated sodium (NaV) channels are responsible for the initiation and conduction of action potentials within primary afferents. The nine NaVchannel isoforms recognized in mammals are often functionally divided into tetrodotoxin (TTX)-sensitive (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c15181b93a62a40541b28f9703583a7
https://doi.org/10.1523/jneurosci.3799-16.2017
https://doi.org/10.1523/jneurosci.3799-16.2017
Autor:
Roberto De Col, Stephan Frings, Nunzia Papotto, Julika Sertel-Nakajima, Margot Maurer, Karl Messlinger, Frank Möhrlen, Richard W. Carr, Markus Schueler
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0211175 (2019)
PLoS ONE, Vol 14, Iss 8, p e0211175 (2019)
Olfactory and trigeminal chemosensory systems reside in parallel within the mammalian nose. Psychophysical studies in people indicate that these two systems interact at a perceptual level. Trigeminal sensations of pungency mask odour perception, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6f4d660118aa509d0c6277f32ab9a6
http://europepmc.org/articles/PMC6693769
http://europepmc.org/articles/PMC6693769