Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Richard W. Birkinshaw"'
Autor:
Dale J. Calleja, Nathan Kuchel, Bernadine G. C. Lu, Richard W. Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P. Cooney, Liana Mackiewicz, Amanda E. Au, Yu Q. Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E. Jarman, Melissa J. Call, Bernhard C. Lechtenberg, Peter E. Czabotar, Marc Pellegrini, Susan A. Charman, Kym N. Lowes, Jeffrey P. Mitchell, Ueli Nachbur, Guillaume Lessene, David Komander
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2. The papain-like protease (PLpro) domain is part of the SARS-CoV-2 non
Externí odkaz:
https://doaj.org/article/78066ca793204c13adcbf61221072dfc
Autor:
Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineag
Externí odkaz:
https://doaj.org/article/b93b0f25bce74b3387360f9736d00ebc
Autor:
Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman, Peter E. Czabotar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The BCL-2 mutation G101V reduces venetoclax affinity and confers drug resistance in patients with chronic lymphocytic leukaemia. Here, the authors present crystal structures and biochemical analyses of venetoclax bound to BCL-2 and the G101V mutant,
Externí odkaz:
https://doaj.org/article/972a06d765d140d0b0bfb95c8133217b
Autor:
Zheng Yuan, Mark F van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J Smith, David C S Huang, Guillaume Lessene, Yelena Khakam, Ruitao Jin, Sitong He, Nicholas A Smith, Richard W Birkinshaw, Peter E Czabotar, Grant Dewson
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002617 (2024)
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial channel prote
Externí odkaz:
https://doaj.org/article/91dcfa91babb4571a0a5c987ad54d99d
Autor:
Andrew W. Roberts, David C.S. Huang, Peter E. Czabotar, John F. Seymour, Constantine S. Tam, David A. Westerman, Daniel H.D. Gray, Ian J. Majewski, Thomas E. Lew, Christoffer Flensburg, Zhen Xu, Tamia Nguyen, Charis E. Teh, Ella R. Thompson, Richard W. Birkinshaw, Rachel Thijssen, Jia-nan Gong, Mary Ann Anderson, Piers Blombery
Supplementary Material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89a0cdbc3aa03a62b92183055427d1b
https://doi.org/10.1158/2159-8290.22532996.v1
https://doi.org/10.1158/2159-8290.22532996.v1
Autor:
Adeline Y. Robin, Michelle S. Miller, Sweta Iyer, Melissa X. Shi, Ahmad Z. Wardak, Daisy Lio, Nicholas A. Smith, Brian J. Smith, Richard W. Birkinshaw, Peter E. Czabotar, Ruth M. Kluck, Peter M. Colman
Publikováno v:
Cell Death & Differentiation. 29:1757-1768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe6a99da41503fc70d9fa77062a0c86
https://doi.org/10.1038/s41418-022-00961-w
https://doi.org/10.1038/s41418-022-00961-w
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
A new untwinned crystal form of the autophagy protein GABARAPL2 is described. The LC3-interacting region (LIR) docking site is blocked by a crystal contact with the C-terminal residue, Phe117. This residue is removed during the processing of GABARAPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a72a1d430f03b3d18bbdb07bfad7d71
https://doi.org/10.1107/s2053230x21004489
https://doi.org/10.1107/s2053230x21004489
Autor:
Jonathan B. Baell, David J. Segal, Amelia Vom, Guillaume Lessene, Hong Yang, David C.S. Huang, Christine A White, M.J. Roy, Brian J. Smith, Richard W Birkinshaw, Peter E. Czabotar, Toru Okamoto, Houda Abdo, Peter M. Colman
Publikováno v:
Journal of Medicinal Chemistry. 64:5447-5469
The BCL-2 family of proteins (including the prosurvival proteins BCL-2, BCL-XL, and MCL-1) is an important target for the development of novel anticancer therapeutics. Despite the challenges of targeting protein-protein interaction (PPI) interfaces w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::757fc6f014ad878b6b173834fd19fe9e
https://doi.org/10.1021/acs.jmedchem.0c01771
https://doi.org/10.1021/acs.jmedchem.0c01771
Autor:
Alan John, Michael Järvå, Alvin W. Lo, Sayali Shah, Richard W Birkinshaw, Runyu Mao, Stephane Chappaz, Nichollas E. Scott, Ethan D. Goddard-Borger, Peter E. Czabotar
Publikováno v:
Nature Chemical Biology. 17:428-437
Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan protists. The prevalence and biological functions of this modification are poorly understood, with progress in the field hampered b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0dcbbc33b0eb00525bf55c80cd36289
https://doi.org/10.1038/s41589-020-00727-w
https://doi.org/10.1038/s41589-020-00727-w
Autor:
Samuel N. Young, Patrick J. Hennessy, Andre L. Samson, Phoebe P. C. Smith, Richard W Birkinshaw, Katherine A Davies, Cheree Fitzgibbon, Emma J. Petrie, Peter E. Czabotar, Andrew I. Webb, Akiko Koide, James M. Murphy, Jarrod J. Sandow, Shohei Koide, Joanne M Hildebrand, Sarah E Garnish, Xavier J Gavin, Eric Denbaum
Publikováno v:
Proc Natl Acad Sci U S A
The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosphorylation of the necroptotic effector pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) by the upstream protein kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f6bb98b7caf6f08a7864ac5643fbb6
https://doi.org/10.1073/pnas.1919960117
https://doi.org/10.1073/pnas.1919960117