Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Richard W. Aldrich"'
Publikováno v:
eLife, Vol 11 (2022)
KCa2.1–3 Ca2+-activated K+-channels (SK) require calmodulin to gate in response to cellular Ca2+. A model for SK gating proposes that the N-terminal domain (N-lobe) of calmodulin is required for activation, but an immobile C-terminal domain (C-lobe
Externí odkaz:
https://doaj.org/article/9c92cc773b6c4dd7ba06c78ddd715c66
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 10, p e1007396 (2019)
The molecular and cellular basis of novelty is an active area of research in evolutionary biology. Until very recently, the vast majority of cellular phenomena were so difficult to sample that cross-species studies of biochemistry were rare and compa
Externí odkaz:
https://doaj.org/article/e680c1ffb4034675aa2471e91e48f37d
Autor:
Chandy George, Israel Hanukoglu, Aguan D. Wei, Jane F. Armstrong, John A. Peters, Roslyn M. Bill, Steve A.N. Goldstein, Lucia G. Sivilotti, Mootaz M. Salman, Heike Wulff, Paul Davies, Michael Zhu, Stephan Kellenberger, Elena Faccenda, Michael F. Jarvis, Dejian Ren, Stefanie Fenske, Emma L. Veale, Jörg Striessnig, Verena Hammelmann, Brian F. King, Terrance P. Snutch, Trevor G. Smart, Leonard K. Kaczmarek, Brenda T. Winn, Eamonn Kelly, Philip Kitchen, Richard W. Aldrich, Jamie A. Davies, Charlotte Van den Eynde, Lachlan D. Rash, Edward Perez-Reyes, Elvir Becirovic, Christopher Southan, Joris Vriens, William A. Catterall, Jinbin Tian, Martin Biel, Adam J. Pawson, Leigh D. Plant, Alistair Mathie, Kotdaji Ha, James S. Trimmer, Bernard Attali, Anders A. Jensen, Lixia Yue, Joseph W. Lynch, Austin M. Baggetta, Haoxing Xu, Charles Kennedy, Xiaoli Zhang, Stephen P.H. Alexander, Simon D. Harding, Markus Delling, Simonetta Falzoni, Stephan Grissmer, Francesco Di Virgilio, Alex C. Conner
Publikováno v:
British journal of pharmacology, vol. 178 Suppl 1, pp. S157-S245
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d921561f4575efc693e15cc0f59fd20
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf
Autor:
Stephan Grissmer, Aguan D. Wei, Leonard K. Kaczmarek, Richard W. Aldrich, George A. Gutman, K. George Chandy, Heike Wulff
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo sub
Autor:
Lakshmi Srinivasan, Manu Ben-Johny, Jesse B. Yoder, Gordon F. Tomaselli, Richard W. Aldrich, L. Mario Amzel, Sara Nathan, Sandra B. Gabelli
Publikováno v:
The Journal of General Physiology
In this review, Nathan et al. discuss recent structural insights into the regulation of the Na+ channels NaV1.5 and NaV1.4, facilitated by the combination of cryo-EM and x-ray crystallography data.
Voltage-gated sodium channels (NaVs) are membra
Voltage-gated sodium channels (NaVs) are membra
Autor:
D. Brent Halling, Edward M. Marcotte, Richard W. Aldrich, Rebecca L. Young, Benjamin J. Liebeskind
New proteomics methods make it possible to determine protein interaction maps at the proteome scale without the need for genetically encoded tags, opening up new organisms and tissue types to investigation. Current molecular and computational methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa14c0c83af3b24507748dd2dfe2df4
https://doi.org/10.1101/2020.01.26.920447
https://doi.org/10.1101/2020.01.26.920447
Publikováno v:
The Journal of General Physiology
Precise mathematical descriptions of ligand–protein interactions are hindered by the inability to experimentally measure affinity and cooperativity, although these parameters can be estimated from agonist binding models. Middendorf and Aldrich pres
Autor:
K. George Chandy, Leonard K. Kaczmarek, Aguan Wei, Stephan Grissmer, Richard W. Aldrich, Heike Wulff
Publikováno v:
Pharmacological reviews, vol 69, iss 1
Kaczmarek, LK; Aldrich, RW; Chandy, KG; Grissmer, S; Wei, AD; & Wulff, H. (2017). International union of basic and clinical pharmacology. C. Nomenclature and properties of calcium-activated and sodium-activated potassium channels. Pharmacological Reviews, 69(1), 1-11. doi: 10.1124/pr.116.012864. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8526x75k
Kaczmarek, LK; Aldrich, RW; Chandy, KG; Grissmer, S; Wei, AD; & Wulff, H. (2017). International union of basic and clinical pharmacology. C. Nomenclature and properties of calcium-activated and sodium-activated potassium channels. Pharmacological Reviews, 69(1), 1-11. doi: 10.1124/pr.116.012864. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8526x75k
© 2016 by The Author(s). Asubset of potassium channels is regulated primarily by changes in the cytoplasmic concentration of ions, including calcium, sodium, chloride, and protons. The eight members of this subfamily were originally all designated a