Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Richard W. Pastor"'
Autor:
Amy Rice, Sourav Haldar, Eric Wang, Paul S. Blank, Sergey A. Akimov, Timur R. Galimzyanov, Richard W. Pastor, Joshua Zimmerberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Target membrane poration is a longstanding enigma in virology. Here, authors show that fusion peptides of the influenza virus’ spike protein aggregate, rotate, and tilt in membranes, facilitating peptide-induced poration during viral fusion.
Externí odkaz:
https://doaj.org/article/032e71bde5444d9ea7d8158275f55efe
Autor:
Denis Sviridov, Amaury Dasseux, Mart Reimund, Milton Pryor, Steven K. Drake, Zack Jarin, Anna Wolska, Richard W. Pastor, Alan T. Remaley
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionDefects in lipolysis can lead to hypertriglyceridemia, which can trigger acute pancreatitis and is also associated with cardiovascular disease. Decreasing plasma triglycerides (TGs) by activating lipoprotein lipase (LPL) with ApoC2 mimeti
Externí odkaz:
https://doaj.org/article/80c53a85249945169ab2f857e1ff211d
Autor:
An Ghysels, Andreas Krämer, Richard M. Venable, Walter E. Teague, Edward Lyman, Klaus Gawrisch, Richard W. Pastor
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Increasing evidence supports the existence of ordered nanodomains (or rafts) in cholesterol rich cell membranes. Here authors present molecular dynamics simulations and EPR experiments to monitor permeation of oxygen and water through membranes in th
Externí odkaz:
https://doaj.org/article/e91db752ad0d4f168ae8b7aecf6084be
Autor:
Yalun Yu, Richard M. Venable, Jonathan Thirman, Payal Chatterjee, Anmol Kumar, Richard W. Pastor, Benoît Roux, Alexander D. MacKerell, Jeffery B. Klauda
Publikováno v:
Journal of Chemical Theory and Computation. 19:2590-2605
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::207b9646d80f3fc670c3896a17991c15
https://doi.org/10.1021/acs.jctc.3c00203
https://doi.org/10.1021/acs.jctc.3c00203
Publikováno v:
Biophysical Journal. 122:E1-E8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f7a48bb043ed1acae23808f1f800bfd
https://doi.org/10.1016/j.bpj.2023.02.022
https://doi.org/10.1016/j.bpj.2023.02.022
Publikováno v:
Biophysical Journal. 122:1094-1104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a275810429f54c31b8e088f12b37540
https://doi.org/10.1016/j.bpj.2023.01.038
https://doi.org/10.1016/j.bpj.2023.01.038
Publikováno v:
Biophysical Journal. 122:1018-1032
The fusion peptide (FP) domain is necessary for the fusogenic activity of spike proteins in a variety of enveloped viruses, allowing the virus to infect the host cell, and is the only part of the protein that interacts directly with the target membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894c6e1498d66f399248d5ee46c1833e
https://doi.org/10.1016/j.bpj.2022.12.029
https://doi.org/10.1016/j.bpj.2022.12.029
Autor:
Rafique M. Islam, Mohsen Pourmousa, Denis Sviridov, Scott M. Gordon, Edward B. Neufeld, Lita A. Freeman, B. Scott Perrin, Richard W. Pastor, Alan T. Remaley
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Peptides mimicking the major protein of highdensity lipoprotein (HDL), apolipoprotein A-I (apoA-I), are promising therapeutics for cardiovascular diseases. Similar to apoA-I, their atheroprotective property is attributed to their ability to
Externí odkaz:
https://doaj.org/article/f6efbe4920c04c43bd95b4e576884d48
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236201 (2020)
Interaction of phospholipase D2 (PLD2) with phosphatidylinositol (4,5)-bisphosphate (PIP2) is regarded as the critical step of numerous physiological processes. Here we build a full-length model of human PLD2 (hPLD2) combining template-based and ab i
Externí odkaz:
https://doaj.org/article/c4c5a497b37f4eb9b591d57774789064
Publikováno v:
Biophys J
It has been proposed that the surface tension difference between leaflets (or differential stress) in asymmetric bilayers is generally nonvanishing. This implies that there is no unique approach to generate initial conditions for simulations of asymm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc73b3be18a1a0a2f1780c1092f15784
https://doi.org/10.1016/j.bpj.2021.10.009
https://doi.org/10.1016/j.bpj.2021.10.009