Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Richard W Stokes"'
Autor:
Jim Sun, Vijender Singh, Alice Lau, Richard W Stokes, Andrés Obregón-Henao, Ian M Orme, Dennis Wong, Yossef Av-Gay, Zakaria Hmama
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003499 (2013)
Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host macrophage and identifying mycobacterial factors responsible for it are keys to better understand tuberculosis pathogenesis. The emerging picture from ongoing studies
Externí odkaz:
https://doaj.org/article/7337e941e463468787ed22380ba6d8b9
Autor:
Alice H Li, Simon J Waddell, Jason Hinds, Chad A Malloff, Manjeet Bains, Robert E Hancock, Wan L Lam, Philip D Butcher, Richard W Stokes
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11066 (2010)
H37Rv and H37Ra are well-described laboratory strains of Mycobacterium tuberculosis derived from the same parental strain, H37, that show dramatically different pathogenic phenotypes.In this study, the transcriptomes of the two strains during axenic
Externí odkaz:
https://doaj.org/article/780a64bf82654027a3fca32b503b54a2
Autor:
H. Klingemann, E. Gibbons, S. Farmer, G. H. N. Towers, Lorne A. Babiuk, P. Sokol, Lisa Thorson, J. Page, G. Saxena, A.R. McCutcheon, T.E. Roberts, H. Matsuura, Richard W. Stokes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa08c71d9e99005a638c4723b9c81449
https://doi.org/10.1201/9781315139272-7
https://doi.org/10.1201/9781315139272-7
Autor:
Simon J. Waddell, Richard W. Stokes
Publikováno v:
Future Microbiology. 4:1317-1335
Mycobacterium tuberculosis remains the most significant single species of bacteria causing disease in mankind. The ability of M. tuberculosis to survive and replicate within host macrophages is a pivotal step in its pathogenesis. Understanding the mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a80d842fb95426af1dde762d7fe2d63
https://doi.org/10.2217/fmb.09.94
https://doi.org/10.2217/fmb.09.94
Publikováno v:
Microbiology. 154:2291-2303
To identify genes involved in the intracellular survival of Mycobacterium tuberculosis we compared the transcriptomes of virulent (H37Rv) and attenuated (H37Ra) strains during their interaction with murine bone-marrow-derived macrophages. Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4835e0fac25310c79f116a5cbb53dfb
https://doi.org/10.1099/mic.0.2008/019661-0
https://doi.org/10.1099/mic.0.2008/019661-0
Autor:
Jennifer Lynett, Richard W. Stokes
Publikováno v:
Microbiology. 153:3133-3140
Alterations to the composition or architecture of the mycobacterial cell envelope can affect the macrophage infectivity of the bacillus. To further characterize the mycobacterial gene products that modulate the interaction with host cells, we employe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8557ce9e125b0fc3f3fbac497b9c5652
https://doi.org/10.1099/mic.0.2007/007864-0
https://doi.org/10.1099/mic.0.2007/007864-0
Autor:
Jun Wang, Mary Hitt, Michael Santosuosso, Zhou Xing, Kris Huygen, Anna Zganiacz, Richard W. Stokes, Lisa Thorson
Publikováno v:
The Journal of Immunology. 173:6357-6365
Bacillus Calmette-Guérin (BCG) vaccine has failed to control the global tuberculosis (TB) epidemic, and there is a lack of safe and effective mucosal vaccines capable of potent protection against pulmonary TB. A recombinant replication-deficient ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a42bcb6a2e7cc308c4b20268edc45a
https://doi.org/10.4049/jimmunol.173.10.6357
https://doi.org/10.4049/jimmunol.173.10.6357
Autor:
Raymond Norris-Jones, Lisa Thorson, Richard W. Stokes, Terry J. Beveridge, Dan Doxsee, Donald E. Brooks
Publikováno v:
Infection and Immunity. 72:5676-5686
Mycobacterium tuberculosis, the causative agent of tuberculosis, is a facultative intracellular pathogen that infects macrophages and other host cells. We show that sonication ofM. tuberculosisresults in the removal of material from the surface capsu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7abdff8145db6fb63318681f54bfee0
https://doi.org/10.1128/iai.72.10.5676-5686.2004
https://doi.org/10.1128/iai.72.10.5676-5686.2004
Autor:
Valerie Mizrahi, Mary Ko, Neora Pick, Bhavna G. Gordhan, Joanna Betts, Siobhán C. Cowley, Katrina J. Downing, Rayken Chow, Debbie A. Smith, Richard W. Stokes, Yossef Av-Gay
Publikováno v:
Molecular Microbiology. 52:1691-1702
Summary The function of the Mycobacterium tuberculosis eukaryotic-like protein serine/threonine kinase PknG was investigated by gene knock-out and by expres- sion and biochemical analysis. The pkn G gene (Rv0410c), when cloned and expressed in Escher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe23e1cc39883e87f2c64aa13e0682c6
https://doi.org/10.1111/j.1365-2958.2004.04085.x
https://doi.org/10.1111/j.1365-2958.2004.04085.x
Publikováno v:
Cellular Immunology. 205:13-23
Using CD11b knockout mice as a source of macrophages (Mphi;), we show that complement receptor 3 (CR3) mediates approximately 40-50% of nonopsonic binding and 50-60% of serum-mediated binding of Mycobacterium tuberculosis to resident Mphi;. We demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04b002689025892d325c94c749eafae
https://doi.org/10.1006/cimm.2000.1710
https://doi.org/10.1006/cimm.2000.1710