Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Richard W Melchior"'
Autor:
Danielle I. Aronowitz, Tracy R. Geoffrion, Sarah Piel, Sarah R. Morton, Jonathan Starr, Richard W. Melchior, Hunter A. Gaudio, Rinat Degani, Nicholas J. Widmann, M. Katie Weeks, Nicolina R. Ranieri, Emilie Benson, Tiffany S. Ko, Daniel J. Licht, Marco Hefti, J. William Gaynor, Todd J. Kilbaugh, Constantine D. Mavroudis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5466 (2024)
Optimal oxygen management during pediatric cardiopulmonary bypass (CPB) is unknown. We previously demonstrated an increase in cortical mitochondrial reactive oxygen species and decreased mitochondrial function after CPB using hyperoxic oxygen managem
Externí odkaz:
https://doaj.org/article/3ac3abee895246b5985bf802bad0cc2c
Autor:
Kalil Shaw, Constantine D. Mavroudis, Tiffany S. Ko, Jharna Jahnavi, Marin Jacobwitz, Nicolina Ranieri, Rodrigo M. Forti, Richard W. Melchior, Wesley B. Baker, Arjun G. Yodh, Daniel J. Licht, Susan C. Nicolson, Jennifer M. Lynch
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundSurgical procedures involving the aortic arch present unique challenges to maintaining cerebral perfusion, and optimal neuroprotective strategies to prevent neurological injury during such high-risk procedures are not completely understood.
Externí odkaz:
https://doaj.org/article/94e67cbe43c04745bdfe1432f4e5c1ef
Autor:
Emilie J. Benson, Danielle I. Aronowitz, Rodrigo M. Forti, Alec Lafontant, Nicolina R. Ranieri, Jonathan P. Starr, Richard W. Melchior, Alistair Lewis, Jharna Jahnavi, Jake Breimann, Bohyun Yun, Gerard H. Laurent, Jennifer M. Lynch, Brian R. White, J. William Gaynor, Daniel J. Licht, Arjun G. Yodh, Todd J. Kilbaugh, Constantine D. Mavroudis, Wesley B. Baker, Tiffany S. Ko
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1153 (2023)
Cardiopulmonary bypass (CPB) provides cerebral oxygenation and blood flow (CBF) during neonatal congenital heart surgery, but the impacts of CPB on brain oxygen supply and metabolic demands are generally unknown. To elucidate this physiology, we used
Externí odkaz:
https://doaj.org/article/412899bb1f7d4941a34146ce6a1c8ab8
Autor:
Tiffany S. Ko, Constantine D. Mavroudis, Emilie J. Benson, Rodrigo M. Forti, Richard W. Melchior, Timothy W. Boorady, Vincent C. Morano, Kobina Mensah-Brown, Yuxi Lin, Danielle Aronowitz, Jonathan P. Starr, Tami M. Rosenthal, Brandon C. Shade, Kellie L. Schiavo, Brian R. White, Jennifer M. Lynch, J. William Gaynor, Daniel J. Licht, Arjun G. Yodh, Wesley B. Baker, Todd J. Kilbaugh
Publikováno v:
Metabolites, Vol 12, Iss 8, p 737 (2022)
Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical re
Externí odkaz:
https://doaj.org/article/242bc912356f49dfbb8517af090a3b4d
Increased cerebral mitochondrial dysfunction and reactive oxygen species with cardiopulmonary bypass
Autor:
Ryan W. Morgan, Richard W Melchior, Alexander Chappell, J. William Gaynor, Anna L. Roberts, Yuxi Lin, Daniel J. Licht, Tiffany Ko, Molly Dreher, William P. Landis, Jonathan Starr, Marco M. Hefti, Lindsay E. Volk, Todd J. Kilbaugh, Jonathan M. Chen, Nile Delso, Douglas Fisher, Tami Rosenthal, Constantine D. Mavroudis, Christopher E. Mascio, Thomas Hallowell
Publikováno v:
Eur J Cardiothorac Surg
OBJECTIVES Neurodevelopmental injury after cardiac surgery using cardiopulmonary bypass (CPB) for congenital heart defects is common, but the mechanism behind this injury is unclear. This study examines the impact of CPB on cerebral mitochondrial rea
Autor:
Richard W Melchior, Alexander Chappell, Molly Dreher, Brandon C. Shade, Tami Rosenthal, Douglas Fisher
Publikováno v:
Perfusion. 36:57-62
Introduction: A device that may help attenuate the amount of homologous blood product given to pediatric cardiac surgical patients is the autotransfusion device. Three separate autotransfusion devices were selected for evaluation. The Sorin Xtra, Fre
Autor:
Richard W Melchior, Douglas Fisher, Tami Rosenthal, David W Holt, Robin High, Brandon C. Shade, Christopher E. Mascio
Publikováno v:
Perfusion. 35:26-31
Background: Vacuum-assisted venous drainage has gained widespread use within the pediatric perfusion community for use during cardiopulmonary bypass. It is questioned whether its efficiency may be compromised with application of excessive cardiotomy
Autor:
Marco M. Hefti, Brian R. White, Jake Breimann, Ryan W. Morgan, Anna L. Roberts, Lindsay E. Volk, Richard W Melchior, Julia C. Slovis, Tiffany Ko, Wesley B. Baker, Giselle Matlis, Arjun G. Yodh, Jharna Jahnavi, Daniel J. Licht, Jonathan Starr, William P. Landis, Kathryn Graham, Tim Benson, Thomas Hallowell, Jonah A. Padawer-Curry, Kristen N. Andersen, Emilie J. Benson, Nile Delso, Alec Lafontant, Yuxi Lin, Todd J. Kilbaugh
Publikováno v:
Optical Tomography and Spectroscopy of Tissue XIV.
Extracorporeal membrane oxygenation (ECMO) is an important therapy for critically ill children but survivors have neurodevelopmental impairments. Cerebral inflammatory response resulting in brain edema is observed on ECMO. This pathologic response ma
Autor:
Yuxi Lin, Wesley B. Baker, Ryan W. Morgan, Robert A. Berg, Lindsay E. Volk, Kathryn Graham, Jonathan Starr, Jake Breimann, Anna L. Roberts, Constantine D. Mavroudis, Arjun G. Yodh, Nile Delso, Tiffany Ko, Jharna Jahnavi, William P. Landis, Kristen N. Andersen, Todd J. Kilbaugh, Richard W Melchior, Thomas Hallowell, Julia C. Slovis, Jonah A. Padawer-Curry, Daniel J. Licht, Emilie J. Benson
Publikováno v:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics.
We examine the correlation of non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) and diffuse correlation spectroscopy (DCS) measurements of cerebral tissue oxygen extraction fraction (OEF) and relative cerebral blood flow (rCBF) wit
Autor:
Daniel J. Licht, Timothy W. Boorady, Vincent C. Morano, Arjun G. Yodh, Brandon C. Shade, Christopher E. Mascio, Wesley B. Baker, Tami Rosenthal, Kellie L. Schiavo, Kobina Mensah-Brown, Constantine D. Mavroudis, Jonah A. Padawer-Curry, Jharna Jahnavi, Lindsay E. Volk, Brian R. White, Tiffany Ko, Jake Breimann, Todd J. Kilbaugh, Richard W Melchior, Alexander L. Schmidt, Kristen N. Andersen, David R. Busch
Publikováno v:
Pediatric research. 91(6)
Background Cerebral autoregulation mechanisms help maintain adequate cerebral blood flow (CBF) despite changes in cerebral perfusion pressure. Impairment of cerebral autoregulation, during and after cardiopulmonary bypass (CPB), may increase risk of