Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Richard W Friesen"'
Autor:
Yves Ducharme, Richard W Friesen, Marc Blouin, Bernard Côté, Daniel Dubé, Diane Ethier, Richard Frenette, France Laliberté, Joseph A Mancini, Paul Masson, Angela Styhler, Robert N Young, Yves Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1923-1926
The synthesis and the phosphodiesterase-4 (PDE4) inhibitory activity of 2-pyridinemethanol derivatives is described. The evaluation of the structure–activity relationship (SAR) in this series of novel PDE4 inhibitors led to the identification of co
Autor:
Richard W. Friesen, Yves Ducharme, Richard G. Ball, Marc Blouin, Louise Boulet, Bernard Côté, Richard Frenette, Mario Girard, Daniel Guay, Zheng Huang, Thomas R. Jones, France Laliberté, Joseph J. Lynch, Joseph Mancini, Evelyn Martins, Paul Masson, Eric Muise, Douglas J. Pon, Peter K. S. Siegl, Angela Styhler, Nancy N. Tsou, Mervyn J. Turner, Robert N. Young, Yves Girard
Publikováno v:
Journal of Medicinal Chemistry. 46:2413-2426
A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFalpha in human whole blood, the binding
Autor:
Richard W. Friesen, Suzanne Bissada
Publikováno v:
Canadian Journal of Chemistry. 76:94-101
Publikováno v:
ChemInform. 22
Autor:
L. G. Phipps, Richard W. Friesen
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 22
A new, concise annulation method leading to the efficient production of structurally novel bicyclic dienes has been developed. The individual synthetic steps that constitute this method, as outlined in general terms in Scheme 1, involve (a) the alkyl
Publikováno v:
ChemInform. 24
Autor:
Richard W. Friesen
Publikováno v:
ChemInform. 33
Publikováno v:
Tetrahedron Letters. 33:6715-6718
Treatment of a variety of tertiary α-allenic alcohols with N-tosyl isocyanate results in a facile and novel rearrangement reaction that provides isolable 2-O-carbamoyl-4,4-disubstituted-1,3-butadienes in a stereoselective manner.