Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Richard W Farndale"'
Autor:
Joy R Wright, Sarah Jones, Sasikumar Parvathy, Leonard K Kaczmarek, Ian Forsythe, Richard W Farndale, Jonathan M Gibbins, Martyn P Mahaut-Smith
Publikováno v:
Platelets, Vol 33, Iss 3 (2022)
Kv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet functio
Externí odkaz:
https://doaj.org/article/ebc5c55ad75949f58bc9d3e1e51b0f27
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69833 (2013)
The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain
Externí odkaz:
https://doaj.org/article/9d1d9f11f659498bb0ecce99ea3115f0
Autor:
Huifang Xu, Dominique Bihan, Francis Chang, Paul H Huang, Richard W Farndale, Birgit Leitinger
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52209 (2012)
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the DDRs bind to specific motifs within the collagen triple helix. However, these two
Externí odkaz:
https://doaj.org/article/929bc50cb8f14b9989eee9e09454b993
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Blood vessels in the body are lined with endothelial cells which have vital roles in numerous physiological and pathological processes. Collagens are major constituents of the extracellular matrix, and many adherent cells express several col
Externí odkaz:
https://doaj.org/article/3e440e3b5a744739b8b7a65733ebca46
Autor:
Johanna P. van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M. E. Tullemans, Fiorella A. Solari, Bing Peng, Kenneth J. Clemetson, Richard W. Farndale, Ludwig J. Dubois, Albert Sickmann, René P. Zahedi, Robert Ahrends, Erik A. L. Biessen, Judith C. Sluimer, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic risk of severe
Externí odkaz:
https://doaj.org/article/1989a910cf91487588230cb6fcebb5c1
Autor:
Natalie J. Jooss, Yvonne M.C. Henskens, Steve P. Watson, Richard W. Farndale, Meinrad P. Gawaz, Martine Jandrot-Perrus, Natalie S. Poulter, Johan W. M. Heemskerk
Publikováno v:
Thrombosis and Haemostasis, 123(06), 597-612. Georg Thieme Verlag
Background In secondary cardiovascular disease prevention, treatments blocking platelet-derived secondary mediators pose a risk of bleeding. Pharmacological interference of the interaction of platelets with exposed vascular collagens is an attractive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d69fea4c173db5a9e93cda1ee3edad5
https://doi.org/10.1055/s-0043-1761463
https://doi.org/10.1055/s-0043-1761463
Autor:
Wing Ying Chow, Chris J. Forman, Dominique Bihan, Anna M. Puszkarska, Rakesh Rajan, David G. Reid, David A. Slatter, Lucy J. Colwell, David J. Wales, Richard W. Farndale, Melinda J. Duer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Fibrillar collagens have mechanical and biological roles, providing tissues with both tensile strength and cell binding sites which allow molecular interactions with cell-surface receptors such as integrins. A key question is: how do collage
Externí odkaz:
https://doaj.org/article/eb22423885e3428eb990590955b04686
Autor:
Haiyan Cai, Parvathy Sasikumar, Gemma Little, Dominique Bihan, Samir W. Hamaia, Aiwu Zhou, Jonathan M. Gibbins, Richard W. Farndale
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 983 (2021)
HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) rep
Externí odkaz:
https://doaj.org/article/0e2bf6621d8448bc963fdb6e3f364675
Autor:
Gavin E. Jarvis, Richard W. Farndale
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Integrins are unusual signalling proteins that function to signal both from the extracellular environment into the cell, but also from the cytoplasm to the external of the cell. The intracellular signalling cascades associated with integrin activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::858a0c8190b9e136d9db2792089af9cc
https://doi.org/10.2218/gtopdb/f760/2023.1
https://doi.org/10.2218/gtopdb/f760/2023.1
Autor:
Louris J. Feitsma, Harma C. Brondijk, Gavin E. Jarvis, Dominique Hagemans, Dominique Bihan, Natasia Jerah, Marian Versteeg, Richard W. Farndale, Eric G. Huizinga
Publikováno v:
Blood. 139:3087-3098
Glycoprotein VI (GPVI) mediates collagen-induced platelet activation after vascular damage and is an important contributor to the onset of thrombosis, heart attack, and stroke. Animal models of thrombosis have identified GPVI as a promising target fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77178e06598c94741629f8e701058272
https://doi.org/10.1182/blood.2021013614
https://doi.org/10.1182/blood.2021013614