Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Richard W Farndale"'
Autor:
Isuru Induruwa, Carly Kempster, Patrick Thomas, Harriet McKinney, Jean-Daniel Malcor, Arkadiusz Bonna, Joana Batista, Kenji Soejima, Willem Ouwehand, Richard W. Farndale, Kate Downes, Masaaki Moroi, Stephanie M. Jung, Elizabeth A. Warburton
Publikováno v:
TH Open, Vol 07, Iss 04, Pp e294-e302 (2023)
Externí odkaz:
https://doaj.org/article/8ae6dcf47e944abfa2c75e9bcb37ce76
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Blood vessels in the body are lined with endothelial cells which have vital roles in numerous physiological and pathological processes. Collagens are major constituents of the extracellular matrix, and many adherent cells express several col
Externí odkaz:
https://doaj.org/article/3e440e3b5a744739b8b7a65733ebca46
Autor:
Johanna P. van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M. E. Tullemans, Fiorella A. Solari, Bing Peng, Kenneth J. Clemetson, Richard W. Farndale, Ludwig J. Dubois, Albert Sickmann, René P. Zahedi, Robert Ahrends, Erik A. L. Biessen, Judith C. Sluimer, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic risk of severe
Externí odkaz:
https://doaj.org/article/1989a910cf91487588230cb6fcebb5c1
Autor:
Joy R Wright, Sarah Jones, Sasikumar Parvathy, Leonard K Kaczmarek, Ian Forsythe, Richard W Farndale, Jonathan M Gibbins, Martyn P Mahaut-Smith
Publikováno v:
Platelets, Vol 33, Iss 3 (2022)
Kv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet functio
Externí odkaz:
https://doaj.org/article/ebc5c55ad75949f58bc9d3e1e51b0f27
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 3, Pp n/a-n/a (2022)
Abstract Background In the fibrin‐forming process, thrombin cleaves fibrinogen to fibrin, which form fibrils and then fibers, producing a gel‐like clot. Thrombin also activates coagulation factor XIII (FXIII), which crosslinks fibrin γ‐chains
Externí odkaz:
https://doaj.org/article/35029e8a0dcc47a9b969f03fa451a698
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 2, Pp 285-297 (2020)
Abstract Objective Platelet surface receptors are also present subcellularly in organelle membranes and can be expressed on the surface upon platelet activation. However, some receptors were reported to be decreased after activation. We analyzed the
Externí odkaz:
https://doaj.org/article/43d58ab8d4c6470faf871b0915f3c187
Autor:
Natalie J. Jooss, Yvonne M.C. Henskens, Steve P. Watson, Richard W. Farndale, Meinrad P. Gawaz, Martine Jandrot-Perrus, Natalie S. Poulter, Johan W. M. Heemskerk
Publikováno v:
Thrombosis and Haemostasis, 123(06), 597-612. Georg Thieme Verlag
Background In secondary cardiovascular disease prevention, treatments blocking platelet-derived secondary mediators pose a risk of bleeding. Pharmacological interference of the interaction of platelets with exposed vascular collagens is an attractive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d69fea4c173db5a9e93cda1ee3edad5
https://doi.org/10.1055/s-0043-1761463
https://doi.org/10.1055/s-0043-1761463
Autor:
Wing Ying Chow, Chris J. Forman, Dominique Bihan, Anna M. Puszkarska, Rakesh Rajan, David G. Reid, David A. Slatter, Lucy J. Colwell, David J. Wales, Richard W. Farndale, Melinda J. Duer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Fibrillar collagens have mechanical and biological roles, providing tissues with both tensile strength and cell binding sites which allow molecular interactions with cell-surface receptors such as integrins. A key question is: how do collage
Externí odkaz:
https://doaj.org/article/eb22423885e3428eb990590955b04686
Autor:
Haiyan Cai, Parvathy Sasikumar, Gemma Little, Dominique Bihan, Samir W. Hamaia, Aiwu Zhou, Jonathan M. Gibbins, Richard W. Farndale
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 983 (2021)
HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) rep
Externí odkaz:
https://doaj.org/article/0e2bf6621d8448bc963fdb6e3f364675
Autor:
María N. Barrachina, Irene Izquierdo, Lidia Hermida-Nogueira, Aurelio M. Sueiro, Esteban Guitián, Felipe F. Casanueva, Richard W. Farndale, Masaaki Moroi, Stephanie M. Jung, María Pardo, Ángel García
Publikováno v:
Data in Brief, Vol 23, Iss , Pp - (2019)
This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” [1]. The study refers t
Externí odkaz:
https://doaj.org/article/879ea1a24be0403ea0dc486246a96d13