Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Richard W, Naylor"'
Autor:
Richard W. Naylor, Lauren Brilli Skvarca, Christine Thisse, Bernard Thisse, Neil A. Hukriede, Alan J. Davidson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
It is unclear how the dorsal-ventral (DV) and anterior-posterior (AP) axes established in the gastrula affect tissues. Here, the authors show that in zebrafish kidney development, with regard to non-axial mesoderm, the classic DV axis corresponds to
Externí odkaz:
https://doaj.org/article/6c5070ea131a42e6a2bce0a514006ddf
Publikováno v:
eLife, Vol 7 (2018)
Transdifferentiation is the poorly understood phenomenon whereby a terminally differentiated cell acquires a completely new identity. Here, we describe a rare example of a naturally occurring transdifferentiation event in zebrafish in which kidney di
Externí odkaz:
https://doaj.org/article/65cd9f5935134c4dbfe22950007a3c78
Autor:
Ranjay, Jayadev, Mychel R P T, Morais, Jamie M, Ellingford, Sandhya, Srinivasan, Richard W, Naylor, Craig, Lawless, Anna S, Li, Jack F, Ingham, Eric, Hastie, Qiuyi, Chi, Maryline, Fresquet, Nikki-Maria, Koudis, Huw B, Thomas, Raymond T, O'Keefe, Emily, Williams, Antony, Adamson, Helen M, Stuart, Siddharth, Banka, Damian, Smedley, David R, Sherwood, Rachel, Lennon
Publikováno v:
Genomics England Research Consortium 2022, ' A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations ', Science Advances, vol. 8, no. 20, eabn2265 . https://doi.org/10.1126/sciadv.abn2265
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of 222 human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d51eaf7f96020b423d4c6daee051185
https://doi.org/10.1126/sciadv.abn2265
https://doi.org/10.1126/sciadv.abn2265
Autor:
Franziska Lausecker, Sybille Koehler, Maryline Fresquet, Richard W. Naylor, Pinyuan Tian, Nicola Wanner, Fabian Braun, Linus Butt, Tobias B. Huber, Rachel Lennon
Publikováno v:
Kidney international. 102(4)
The 13th International Podocyte Conference was held in Manchester, UK, and online from July 28 to 30, 2021. Originally planned for 2020, this biannual meeting was postponed by a year because of the coronavirus disease 2019 (COVID-19) pandemic and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2356c58cc787f3b527ed394786347e5f
https://pubmed.ncbi.nlm.nih.gov/35964799
https://pubmed.ncbi.nlm.nih.gov/35964799
Autor:
Richard W Naylor, Charles N J McGhee, Chad A Cowan, Alan J Davidson, Teresa M Holm, Trevor Sherwin
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165464 (2016)
Corneal diseases such as keratoconus represent a relatively common disorder in the human population. However, treatment is restricted to corneal transplantation, which only occurs in the most advanced cases. Cell based therapies may offer an alternat
Externí odkaz:
https://doaj.org/article/70979c0d66714540a41233eeb30982c9
Publikováno v:
Naylor, R W, Morais, M R P T & Lennon, R 2021, ' Complexities of the glomerular basement membrane ', Nature Reviews Nephrology, vol. 17, no. 2, pp. 112-127 . https://doi.org/10.1038/s41581-020-0329-y
The glomerular basement membrane (GBM) is a key component of the glomerular capillary wall and is essential for kidney filtration. The major components of the GBM include laminins, type IV collagen, nidogens and heparan sulfate proteoglycans. In addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a58ef93610ea0b83776cfbc602835ec
https://doi.org/10.1038/s41581-020-0329-y
https://doi.org/10.1038/s41581-020-0329-y
Autor:
Nikki-Maria Koudis, Damian Smedley, Mychel Rpt Morais, Jamie M Ellingford, Antony Adamson, David R. Sherwood, Maryline Fresquet, Anna S. Li, Sandhya Srinivasan, Eric Hastie, Ranjay Jayadev, Richard W. Naylor, Rachel Lennon, Emily Williams, Raymond T. O'Keefe, Jack F. Ingham, Helen M. Stuart, Craig Lawless, Huw B. Thomas, Qiuyi Chi, Siddharth Banka
SummaryBasement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5abdb5d7cef4df1add0326719cc4136c
https://doi.org/10.1101/2021.10.25.465762
https://doi.org/10.1101/2021.10.25.465762
Autor:
Richard W. Naylor, Elizabeth Watson, Samantha Williamson, Rebecca Preston, J Bernard Davenport, Nicole Thornton, Martin Lowe, Maggie Williams, Rachel Lennon
Publikováno v:
Naylor, R W, Watson, E, Williamson, S, Preston, R, Davenport, J B, Thornton, N, Lowe, M, Williams, M & Lennon, R 2022, ' Basement membrane defects in CD151-associated glomerular disease ', Pediatric Nephrology . https://doi.org/10.1007/s00467-022-05447-y
Background CD151 is a cell-surface molecule of the tetraspanin family. Its lateral interaction with laminin-binding integrin ɑ3β1 is important for podocyte adhesion to the glomerular basement membrane (GBM). Deletion of Cd151 in mice induces glomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3488a914f56da86d50b4488462963d
https://pubmed.ncbi.nlm.nih.gov/35278129
https://pubmed.ncbi.nlm.nih.gov/35278129
Autor:
Richard W. Naylor, Emmanuel Lemarie, Anthony Jackson-Crawford, J. Bernard Davenport, Aleksandr Mironov, Martin Lowe, Rachel Lennon
Publikováno v:
Naylor, R W, Lemarie, E, Jackson-Crawford, A, Davenport, J B, Mironov, A, Lowe, M & Lennon, R 2022, ' A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish ', Kidney International, vol. 102, no. 4, pp. 815-827 . https://doi.org/10.1016/j.kint.2022.05.019
The zebrafish is an important animal system for modeling human diseases. This includes kidney dysfunction as the embryonic kidney (pronephros) shares considerable molecular and morphological homology with the human nephron. A key clinical indicator o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9eaf9d8415452d96081a3274b310ba
https://pubmed.ncbi.nlm.nih.gov/35716957
https://pubmed.ncbi.nlm.nih.gov/35716957
Autor:
Martin Lowe, Anthony Jackson-Crawford, J Bernard Davenport, Emmanuel Lemarie, Richard W. Naylor, Alexander A. Mironov, Rachel Lennon
The zebrafish is an important animal system for modelling human diseases. This includes kidney dysfunction as the embryonic kidney (pronephros) shares considerable molecular and morphological homology with the human nephron. Zebrafish also have a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::910e486b45c308d7b98d20c3885369b3
https://doi.org/10.1101/2021.07.19.452884
https://doi.org/10.1101/2021.07.19.452884