Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Richard Vejsada"'
Autor:
Eugene M. Johnson, Jeffrey Milbrandt, Melanie L. Leitner, Judy P. Golden, Patricia A. Osborne, Derek C. Molliver, Patricia A. Lampe, Richard Vejsada, Ann C. Kato
Publikováno v:
The Journal of Neuroscience. 19:9322-9331
Neurturin (NRTN) and glial cell line-derived neurotrophic factor (GDNF) are members of a family of trophic factors with similar actionsin vitroon certain neuronal classes. Retrograde transport of GDNF and NRTN was compared in peripheral sensory, symp
Publikováno v:
European Journal of Neuroscience. 10:1590-1607
HDs racI Thrombin causes profound metabolic and morphological changes in cultured neural cells via activation of the thrombin receptor, also called protease-activated receptor 1 (PAR1). PAR1 mRNA is present in the rat brain, but the role of this rece
Publikováno v:
The Journal of Neuroscience. 18:1132-1141
It has been shown that abnormalities in axonal transport occur in several mouse models with motoneuron degeneration and also in the human disease amyotrophic lateral sclerosis. In this report, we have examined the potential of neurotrophic factors to
Autor:
Christopher E. Henderson, Daniel Eric Sherman, Frederic J. de Sauvage, Alain Garces, Richard Vejsada, Robert D. Klein, Malú G. Tansey, Kelli S. Simburger, Kristian Todd Poulsen, Patricia A. Lampe, Robert O. Heuckeroth, Christa L. Gray, Eugene M. Johnson, Paul T. Kotzbauer, Judith P. Golden, Ann C. Kato, Li-Chong Wang, Melanie L. Leitner, Jeffrey Milbrandt, Merry Nishimura, Barbara Moffat, Heidi S. Phillips, Richard Vandlen, Robert H. Baloh, Timothy J. Fahrner, Jamie A. Davies, Mary Hynes
Publikováno v:
Neuron. 20(2):245-253
A novel neurotrophic factor named Persephin that is approximately 40% identical to glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) has been identified using degenerate PCR. Persephin, like GDNF and NTN, promotes the survival of
Autor:
Li Pan, Richard Vejsada, Thomas M. DeChiara, Ann Acheson, Chitra Suri, Nancy Y. Ip, Beth Friedman, Ann Kato, Joyce McClain, Neil Stahl, George D. Yancopoulos, Joanne C. Conover, William Poueymirou
Publikováno v:
Cell. 83:313-322
Ciliary neurotrophic factor (CNTF) supports motor neuron survival in vitro and in mouse models of motor neuron degeneration and was considered a candidate for the muscle-derived neurotrophic activity that regulates motor neuron survival during develo
Autor:
A. C. Kato, W. T. Poueymirou, Nancy Y. Ip, Lynne M. Bianchi, T. M. Dechiara, George D. Yancopoulos, Joanne C. Conover, Li Pan, Joyce McClain, Richard Vejsada, Stanley J. Wiegand, Jeffery T. Erickson, Maureen E. Helgren, David M. Katz, Patricia Boland, Beth Friedman
Publikováno v:
Nature. 375:235-238
NERVE growth factor and other neurotrophins signal to neurons through the Trk family of receptor tyrosine kinases1–6. TrkB is relatively promiscuous in vitro, acting as a receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT4) a
Publikováno v:
NeuroReport. 5:1889-1892
Direct application of brain-derived neurotrophic factor (BDNF) to the cut end of axotomized immature motor neurones had only transient survival-promoting effects. Therefore, we have examined whether additional delivery of BDNF with repeated subcutane
Publikováno v:
Trends in pharmacological sciences. 18(9)
Animal models of motor neurone disease (MND) are being increasingly used for screening molecules with clinical potential. A number of different treatments to decrease the progression of neuronal cell loss have been proposed; these include: Bcl-2 (B-c