Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Richard V. Van Rheeden"'
Autor:
Cameron M. Callaghan, Ibrahim M. Abukhiran, Amr Masaadeh, Richard V. Van Rheeden, Amanda L. Kalen, Samuel N. Rodman, Michael S. Petronek, Kranti A. Mapuskar, Benjamin N. George, Mitchell C. Coleman, Prabhat C. Goswami, Bryan G. Allen, Douglas R. Spitz, Joseph M. Caster
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 115:933-944
Ataxia telangiectasia mutated kinase (ATM) inhibitors are potent radiosensitizers that regulate DNA damage responses and redox metabolism, but they have not been translated clinically because of the potential for excess normal tissue toxicity. Pharma
Autor:
Cameron M. Callaghan, Ibrahim M. Abukhiran, Richard V. Van Rheeden, Amanda L. Kalen, Samuel N. Rodman, Michael S. Petronek, Kranti A. Mapuskar, Sarah L. Mott, Mitchell C. Coleman, Prabhat C. Goswami, John M. Buatti, Bryan G. Allen, Douglas R. Spitz, Joseph M. Caster
Publikováno v:
Cancer Research. 82:811-811
Purpose/Objective(s): The ATM protein is key to DNA double strand break (DSB) repair and ATM inhibitors are potent radiosensitizers. Clinical translation of these agents in combination with radiotherapy (RT) has been limited due to concerns for incre