Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Richard V. Pearse"'
Autor:
Vicky Chou, Richard V. Pearse, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioglu, Masashi Fujita, Seeley B. Fancher, Alina Sigalov, Courtney R. Benoit, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young-Pearse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Throug
Externí odkaz:
https://doaj.org/article/9e3d8cd8d32347f6b00af0ac1594f3b7
Autor:
Julie P. Merchant, Kuixi Zhu, Marc Y. R. Henrion, Syed S. A. Zaidi, Branden Lau, Sara Moein, Melissa L. Alamprese, Richard V. Pearse, David A. Bennett, Nilüfer Ertekin-Taner, Tracy L. Young-Pearse, Rui Chang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Despite decades of genetic studies on late-onset Alzheimer’s disease, the underlying molecular mechanisms remain unclear. To better comprehend its complex etiology, we use an integrative approach to build robust predictive (causal) network
Externí odkaz:
https://doaj.org/article/59af61a1276a4d158efbd9462249793a
Autor:
Yi-Chen Hsieh, Joseph Negri, Amy He, Richard V. Pearse, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young-Pearse
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Alzheimer’s Disease (AD) affects millions globally, but therapy development is lagging. New experimental systems that monitor neuronal functions in conditions approximating the AD brain may be beneficial for identifying new ther
Externí odkaz:
https://doaj.org/article/6be3dc2f5fd24619b28eb8ec75d45782
Autor:
Hyo Lee, Aimee J. Aylward, Richard V. Pearse, II, Alexandra M. Lish, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Mariko F. Taga, Kevin Huynh, Matthias Arnold, Peter J. Meikle, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112994- (2023)
Summary: SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were differentiated to neuron, astrocyte
Externí odkaz:
https://doaj.org/article/911ab12d4ed045b69c2a0c7474867a7a
Autor:
Christina R. Muratore, Constance Zhou, Meichen Liao, Marty A. Fernandez, Walter M. Taylor, Valentina N. Lagomarsino, Richard V. Pearse, II, Heather C. Rice, Joseph M. Negri, Amy He, Priya Srikanth, Dana G. Callahan, Taehwan Shin, Monica Zhou, David A. Bennett, Scott Noggle, J. Christopher Love, Dennis J. Selkoe, Tracy L. Young-Pearse
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1868-1884 (2017)
Summary: Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ, whic
Externí odkaz:
https://doaj.org/article/9f03abb62b1343ab8aa8f519af659d78
Autor:
Hyo Lee, Aimee J. Aylward, Richard V. Pearse, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Hans-Ulrich Klein, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Publikováno v:
bioRxiv
SummarySORL1 is strongly implicated in the pathogenesis of Alzheimer’s disease (AD) through human genetic studies that point to an association of reduced SORL1 levels with higher risk for AD. To interrogate the role(s) of SORL1 in human brain cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ca35d64f619357003633b6b32402a
https://doi.org/10.1101/2023.02.25.530017
https://doi.org/10.1101/2023.02.25.530017
Autor:
Hyo Lee, Aimee J Aylward, Richard V Pearse II, Yi‐Chen Hsieh, Zachary M Augur, Allison Knupp, Srilakshmi Goberdhan, Cheryl Pan, Nicholas T. Seyfried, David A Bennett, Philip L De Jager, Jessica E. Young, Tracy Young‐Pearse
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdb64be854043477358ee61d7d654876
https://doi.org/10.1002/alz.067209
https://doi.org/10.1002/alz.067209
Autor:
Yi‐Chen Hsieh, Joseph Negri, Amy He, Richard V Pearse II, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A Bennett, Nicholas T. Seyfried, Tracy Young‐Pearse
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bad55b54c0a46e5d7ba5953e534f20d
https://doi.org/10.1002/alz.059823
https://doi.org/10.1002/alz.059823
Autor:
Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C. White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V. Pearse, Atlas Khan, Badri N. Vardarajan, Krzysztof Kiryluk, Chun Jimmie Ye, Hans-Ulrich Klein, Gao Wang, Aviv Regev, Naomi Habib, Julie A. Schneider, Yanling Wang, Tracy Young-Pearse, Sara Mostafavi, David A. Bennett, Vilas Menon, Philip L. De Jager
The relationship between genetic variation and gene expression in individual brain cell types and subtypes has remained elusive. Here, we generated single-nucleus RNA sequencing data from the dorsolateral prefrontal cortex of 424 individuals of advan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f17b25079865559b48f50c6e896785d
https://doi.org/10.1101/2022.11.07.515446
https://doi.org/10.1101/2022.11.07.515446
Autor:
Julie P. Merchant, Kuixi Zhu, Marc Y.R. Henrion, Syed S.A. Zaidi, Lau Branden, Sara Moein, Melissa L. Alamprese, Richard V. Pearse, David A. Bennett, Nilüfer Ertekin-Taner, Tracy L. Young-Pearse, Rui Chang
SummaryDespite decades of genetic studies on late onset Alzheimer’s disease (LOAD), the molecular mechanisms of Alzheimer’s disease (AD) remain unclear. Furthermore, different cell types in the central nervous system (CNS) play distinct roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a87d44e5deedcfff4abfe4cb1558cb
https://doi.org/10.1101/2022.10.19.512949
https://doi.org/10.1101/2022.10.19.512949