Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Richard V. Coelho"'
Autor:
Surabhi Nair, Vijay Gottumukkala, Keryn Palmer, Richard V. Coelho, Timothy K. Erick, Rahul Puri, Vanessa J. Kelly, Ohad Ilovich, Shu-ta Wu, Pinku Mukherjee
Publikováno v:
Theranostics
Rationale: Transformed MUC1 (tMUC1) is a cancer-associated antigen that is overexpressed in >90% of triple-negative breast cancers (TNBC), a highly metastatic and aggressive subtype of breast cancer. TAB004, a murine antibody targeting tMUC1, has sho
Autor:
Nandini Chaturbhai Patel, Richard V. Coelho, Christopher John Helal, Chewah Lee, Anabella Villalobos, Shawn D. Doran, Joseph Michael Young, Robert J. Mather, Simone Sciabola, Erik Alphie Lachapelle, John T. Lazzaro, Thomas Allen Chappie, Patrick Robert Verhoest, Zoë A. Hughes, Marc B. Skaddan, Elizabeth Mary Beck, John M. Humphrey, Kyle Kuszpit, Laigao Chen, Lei Zhang, Kenneth R. Zasadny, Kuo-Hsien Fan
Publikováno v:
Journal of Medicinal Chemistry. 60:8538-8551
As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomography (PET) ligand to enable target occupancy measuremen
Autor:
Richard V. Coelho, Jenna M. Sullivan, Marc Berridge, Eric E. Swayze, Fredrik Kamme, Vijay Gottumukkala, Hemi Dimant, Holly Kordasiewicz, Carolynn M. Gaut, Michael Oestergaard, Kenneth R. Zasadny, Mohammed Q. Qutaish, Roxana O. Carare, John Matson, Ajay Verma, Jacob Hesterman, Berit Powers, Curt Mazur, Louise Kelly, Ildiko Polyak, Marc Seaman, Jack Hoppin, Robert W. Holt, Nazira J. Albargothy
Intrathecal (IT) delivery and pharmacology of antisense oligonucleotides (ASOs) for the CNS have been successfully developed to treat spinal muscular atrophy. However, ASO pharmacokinetic (PK) and pharmacodynamic (PD) properties remain poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae19005b638a7dcfc26be9c2575487b
https://europepmc.org/articles/PMC6824309/
https://europepmc.org/articles/PMC6824309/
Autor:
Rahul Puri, Vijay Gottumukkala, Ohad Ilovich, Vanessa J. Kelly, Shu-ta Wu, Pinku Mukherjee, Richard V. Coelho
Publikováno v:
Cancer Research. 79:LB-281
Purpose: The purpose of this study was to develop an Indium-111/Actinium-225 based theragnostic utilizing the tMUC1 targeting humanized antibody, TAB004, and its evaluation in a tumor bearing rodent model. Triple negative breast cancer (TNBC) is an a
Autor:
Thomas M.A. Bocan, Kuo-Hsien Fan, Douglas S. Johnson, Benjamin F. Cravatt, Gayatri Balan, Susan E. Drozda, Anabella Villalobos, Marc B. Skaddan, Gwen Currier, Kyle Kuszpit, Aijun Zhu, Kenneth R. Zasadny, Elizabeth Mary Beck, Lei Zhang, Kay Ahn, Richard V. Coelho, Micah J. Niphakis, Laigao Chen
Publikováno v:
Nuclear Medicine and Biology. 39:1058-1067
Fatty acid amide hydrolase (FAAH) is responsible for the enzymatic degradation of the fatty acid amide family of signaling lipids, including the endogenous cannabinoid (endocannabinoid) anandamide. The involvement of the endocannabinoid system in pai
Autor:
Rahul Puri, Shu-ta Wu, Vijay Gottumukkala, Laura Jeffords Moore, Richard V. Coelho, Vanessa J. Kelly, Pinku Mukherjee, Ohad Ilovich
Publikováno v:
Journal of Clinical Oncology. 36:e13112-e13112
e13112Background: Breast cancer (BC) remains a leading cause of cancer-related deaths worldwide. Triple negative breast cancer (TNBC) is an aggressive phenotype that comprises only 15-20% of all ne...
Autor:
Stephanie L. Coffing, Victor F. Soliman, Evan Smith, Richard V. Coelho, Jiri Aubrecht, Klaas Schildknegt, Jennifer R. Cheung, Mary E. Lame, Tristan S. Maurer, Phoebe Chiang, Deepak Dalvie, Chandra Vage, Amit S. Kalgutkar, Kim F. McClure
Publikováno v:
Drug Metabolism and Disposition. 35:848-858
2-(3-Chlorobenzyloxy)-6-(piperazin-1-yl)pyrazine (3) is a potent and selective 5-HT(2C) agonist that exhibits dose-dependent inhibition of food intake and reduction in body weight in rats, making it an attractive candidate for treatment of obesity. H
Autor:
Klaas Schildknegt, Richard V. Coelho
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:675-678
An efficient large-scale carbon-14 synthesis of 1H-indazole-[3-14C]carboxylic acid starting from [14C]potassium cyanide is reported. Key transformations encountered during the synthesis include aromatic nucleophilic substitution of 2-nitrofluorobenze
Autor:
Kevin Colizza, Amin Kamel, Weiwei Wang, R. Scott Obach, Klaas Schildknegt, Thomas N. O'Connell, Ryan M. Kelley, Richard V. Coelho
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(11)
The metabolism, pharmacokinetics, and excretion of a potent and selective 5-hydroxytryptamine(1B) receptor antagonist elzasonan have been studied in six healthy male human subjects after oral administration of a single 10-mg dose of [(14)C]elzasonan.