Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Richard V. Clark"'
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments.
Externí odkaz:
https://doaj.org/article/e1f73e6f4eda4a62a3d79d3777de791e
Autor:
Rosaly Correa-de-Araujo, Odessa Addison, Iva Miljkovic, Bret H. Goodpaster, Bryan C. Bergman, Richard V. Clark, Joanne W. Elena, Karyn A. Esser, Luigi Ferrucci, Michael O. Harris-Love, Steve B. Kritchevsky, Amanda Lorbergs, John A. Shepherd, Gerald I. Shulman, Clifford J. Rosen
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An in
Externí odkaz:
https://doaj.org/article/8f5c671a2db841feae7bac121af5d86b
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-1 (2018)
Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.
Externí odkaz:
https://doaj.org/article/d03026fdb79744668aebcc8fa062fee1
Autor:
John A. Shepherd, Steve B. Kritchevsky, Joanne W. Elena, Clifford J. Rosen, Michael O. Harris-Love, Amanda L. Lorbergs, Iva Miljkovic, Gerald I. Shulman, Bret H. Goodpaster, Bryan C. Bergman, Luigi Ferrucci, Richard V. Clark, Rosaly Correa-de-Araujo, Karyn A. Esser, Odessa Addison
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology, Vol 11 (2020)
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An in
Autor:
David Neil, Zhengyu Xue, Julia Billiard, Alan J. Russell, Mindy Magee, Ann Chan, Richard V. Clark
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 103:3215-3224
Context GlaxoSmithKline (GSK) 2881078 is a nonsteroidal, selective androgen receptor modulator (SARM) under investigation by GSK for treatment of reduced mobility and other functional limitation in men and women with muscle weakness associated with c
Autor:
Robin L. O'Connor-Semmes, Ann C. Walker, Richard V. Clark, William T. Cefalu, Eric Ravussin, Ram R. Miller
Publikováno v:
Journal of Applied Physiology. 124:1-9
A noninvasive method to estimate muscle mass based on creatine ( methyl-d3) (D3-creatine) dilution using fasting morning urine was evaluated for accuracy and variability over a 3- to 4-mo period. Healthy older (67- to 80-yr-old) subjects ( n = 14) wi
Publikováno v:
Birth Defects Research. 110:17-26
Background Testing of pharmaceutical products for reproductive toxicity in male laboratory animals is required for registration. Methods We evaluated whether the results of studies showing male reproductive toxicity in experimental animals was predic
Autor:
Richard V. Clark, Susan Andrews, Ann C. Walker, Mindy Magee, Philip Turnbull, Jeffrey A. Wald
Publikováno v:
British Journal of Clinical Pharmacology. 83:2179-2194
Aim Selective androgen receptor modulators (SARMs) induce anabolic effects on muscle without the adverse effects of androgenic steroids. In this first-in-human study, we report the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of t
Autor:
Alan V. McDougal, John J. Lepore, Samuel E. Honeycutt, Andrew N. Billin, Henning F Kramer, Deepak K. Rajpal, Bert Yao, Zhe Chen, Aaron C. Hinken, Richard V. Clark, Kazunori Nosaka, Ram Miller, Johannes M. Freudenberg, Frank Fang, Robert S. Geske, Alex Cobitz, Guizhen Luo, Jaclyn P. Kerr, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-1 (2018)
Skeletal Muscle
Skeletal Muscle
Background In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-i
Autor:
Ronald S. Swerdloff, Christina Wang, Alvin M. Matsumoto, Jeffrey A. Wald, Frederick C. W. Wu, Larry D. Bowers, Richard V. Clark
Publikováno v:
Clark, R V, Wald, J A, Swerdloff, R S, Wang, C, Wu, F C W, Bowers, L D & Matsumoto, A M 2018, ' Large divergence in testosterone concentrations between men and women: Frame of reference for elite athletes in sex-specific competition in sports, a narrative review ', Clinical Endocrinology . https://doi.org/10.1111/cen.13840
ObjectiveThe purpose of this narrative review was to summarize available data on testosterone levels in normal, healthy adult males and females, to provide a physiologic reference framework to evaluate testosterone levels reported in males and female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed779516e1e63b02ecba0b2cfb25d0fd
https://www.research.manchester.ac.uk/portal/en/publications/large-divergence-in-testosterone-concentrations-between-men-and-women-frame-of-reference-for-elite-athletes-in-sexspecific-competition-in-sports-a-narrative-review(a80e41f6-d5ae-42db-86cf-b4f302d89510).html
https://www.research.manchester.ac.uk/portal/en/publications/large-divergence-in-testosterone-concentrations-between-men-and-women-frame-of-reference-for-elite-athletes-in-sexspecific-competition-in-sports-a-narrative-review(a80e41f6-d5ae-42db-86cf-b4f302d89510).html