Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Richard Truse"'
Autor:
Stefan Hof, Hendrik Untiedt, Anne Hübner, Carsten Marcus, Anne Kuebart, Anna Herminghaus, Christian Vollmer, Inge Bauer, Olaf Picker, Richard Truse
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The maintenance of intestinal integrity and barrier function under conditions of restricted oxygen availability is crucial to avoid bacterial translocation and local inflammation. Both lead to secondary diseases after hemorrhagic shock and m
Externí odkaz:
https://doaj.org/article/5f29694f21d14211bfb6a85687317df5
Autor:
Stefan Hof, Lara Lingens, Marius Michels, Carsten Marcus, Anne Kuebart, Anna Herminghaus, Inge Bauer, Olaf Picker, Richard Truse, Christian Vollmer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHemorrhagic shock is characterized by derangements of the gastrointestinal microcirculation. Topical therapy with nitroglycerine or iloprost improves gastric tissue oxygenation but not regional perfusion, probably due to precapillary adre
Externí odkaz:
https://doaj.org/article/efb6b3e299534c20abffc057d85cc849
Autor:
Stefan Hof, Carsten Marcus, Anne Kuebart, Jan Schulz, Richard Truse, Annika Raupach, Inge Bauer, Ulrich Flögel, Olaf Picker, Anna Herminghaus, Sebastian Temme
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Impaired oxygen utilization is the underlying pathophysiological process in different shock states. Clinically most important are septic and hemorrhagic shock, which comprise more than 75% of all clinical cases of shock. Both forms lead to severe dys
Externí odkaz:
https://doaj.org/article/7298c05031864fe8878d6e977b4196fa
Autor:
Stefan Hof, Richard Truse, Lea Weber, Anna Herminghaus, Jan Schulz, Andreas P. M. Weber, Eva Maleckova, Inge Bauer, Olaf Picker, Christian Vollmer
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
IntroductionAcute hemorrhage results in perfusion deficit and regional hypoxia. Since failure of intestinal integrity seem to be the linking element between hemorrhage, delayed multi organ failure, and mortality, it is crucial to maintain intestinal
Externí odkaz:
https://doaj.org/article/0ec9c32d448c406a8000e4a57584e4e5
Autor:
Jan Schulz, Sandra Kramer, Yasin Kanatli, Anne Kuebart, Inge Bauer, Olaf Picker, Christian Vollmer, Richard Truse, Anna Herminghaus
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IntroductionIn the immunology of sepsis microcirculatory and mitochondrial dysfunction in the gastrointestinal system are important contributors to mortality. Hydrogen sulfide (H2S) optimizes gastrointestinal oxygen supply and mitochondrial respirati
Externí odkaz:
https://doaj.org/article/4a301e77b1884464a71ec1bc45d09eef
Autor:
Richard Truse, Steven Grewe, Anna Herminghaus, Jan Schulz, Andreas P. M. Weber, Tabea Mettler-Altmann, Inge Bauer, Olaf Picker, Christian Vollmer
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-13 (2019)
Abstract Background Hypercapnia improves gastric microcirculatory oxygenation (μHbO2) and increases vasopressin plasma levels, whereas V1A receptor blockade abolishes the increase of μHbO2. The aim of this study was to evaluate the effect of exogen
Externí odkaz:
https://doaj.org/article/48b65d89b3df424083d7769e31cd5874
Autor:
Anna Herminghaus, Henrike Papenbrock, Rebecca Eberhardt, Christian Vollmer, Richard Truse, Jan Schulz, Inge Bauer, Adelheid Weidinger, Andrey V. Kozlov, Johnny Stiban, Olaf Picker
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background Evidence suggests that early adaptive responses of hepatic mitochondria occur in experimentally induced sepsis. Little is known about both colonic mitochondrial function during abdominal infection and long-term changes in mitochon
Externí odkaz:
https://doaj.org/article/46a776e596a7422989ff72c7f86e73df
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257034 (2021)
IntroductionSepsis impairs gastrointestinal microcirculation and it is hypothesized that this might increase patient's mortality. Sub-therapeutic vasopressin improves gastric microcirculation under physiologic conditions whereas a therapeutic dosing
Externí odkaz:
https://doaj.org/article/613b41c78d1c4a798747a2a1d93ff1c9
Autor:
Richard Truse, Inga Nolten, Jan Schulz, Anna Herminghaus, Tobias Holtmanns, Lukas Gördes, Annika Raupach, Inge Bauer, Olaf Picker, Christian Vollmer
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Systemic administration of melatonin exerts tissue protective effects in the context of hemorrhagic shock. Intravenous application of melatonin prior to hemorrhage improves gastric microcirculatory perfusion and maintains intestinal barrier function
Externí odkaz:
https://doaj.org/article/fb998d393a824f889215d773029a50f2
Autor:
Anna Herminghaus, Albert J. Buitenhuis, Jan Schulz, Richard Truse, Christian Vollmer, Borna Relja, Inge Bauer, Olaf Picker
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Background: Studies suggest that indomethacin (Indo) exhibits detrimental changes in the small intestine (microvascular disorder, villus shortening, and epithelial disruption), mainly due to mitochondrial uncoupling. The effects of Indo on colon and
Externí odkaz:
https://doaj.org/article/c47edbf2b642433ab14c1977670969a2