Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Richard Trilles"'
Autor:
Kali R. Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M. Pimentel-Elardo, Jen L. Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, José F. Muñoz, Sang Hu Kim, John A. Porco, Christina A. Cuomo, Noelle S. Williams, Ashraf S. Ibrahim, John E. Edwards, David R. Andes, Justin R. Nodwell, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major effl
Externí odkaz:
https://doaj.org/article/2c173732359e4b30bf7d56530b8aca91
Autor:
Luke Whitesell, Nicole Robbins, David S. Huang, Catherine A. McLellan, Tanvi Shekhar-Guturja, Emmanuelle V. LeBlanc, Catherine S. Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L. Xie, Damian J. Krysan, Susan Lindquist, John A. Porco, Utpal Tatu, Lauren E. Brown, Juan Pizarro, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstr
Externí odkaz:
https://doaj.org/article/c204109fbee74209af84981ef754b8a6
Autor:
Kali Iyer, Kaddy Camara, Martin Daniel-Ivad, Nicole Revie, Jennifer Lou, Sheena Li, Richard Trilles, Sheila Elardo, Yoko Yashiroda, Jen Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, Jose Muñoz, Sang Hu Kim, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Christina Cuomo, Noelle Williams, Ashraf Ibrahim, Jack Edwards, David Andes, Justin Nodwell, John Porco, Charlie Boone, Mohammad Mazhab-Jafari, Lauren Brown, Luke Whitesell, Nicole Robbins, Leah Cowen
Publikováno v:
Access Microbiology. 3
The rise in drug resistance amongst pathogenic fungi, paired with the limited arsenal of antifungals available is an imminent threat to our medical system. To address this, we screened two distinct compound libraries to identify novel strategies to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d25588ce823236432c9f5519dc089a7
https://doi.org/10.1099/acmi.cc2021.po0006
https://doi.org/10.1099/acmi.cc2021.po0006
Autor:
Tristan M G Kenney, Douglas A. Kuntz, Luke Whitesell, Paul T Marcyk, Alice Xue, Gilbert G. Privé, Emmanuelle V. LeBlanc, Noelle S. Williams, Lauren E. Brown, Stephen Bengtson, David S. Huang, Leah E. Cowen, Richard Trilles, Francisco Ortiz, Nicole Robbins, Damian J. Krysan
Publikováno v:
J Med Chem
The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51437590f15295e1392ea1f21207b793
https://pubmed.ncbi.nlm.nih.gov/33444025
https://pubmed.ncbi.nlm.nih.gov/33444025
Autor:
Daniel F. Tardiff, Richard Trilles, Susan Lindquist, M. Inmaculada Barrasa, Kim A. Caldwell, Nathan T. Jui, Scott E. Schaus, Xiaohui Yan, Guy A. Caldwell, Lauren E. Brown
Publikováno v:
ACS Chemical Neuroscience. 8:2039-2055
The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems. It is critical that we develop approaches to identify novel targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f782da1db7bed5c355a4c392ff9d0b
https://doi.org/10.1021/acschemneuro.7b00187
https://doi.org/10.1021/acschemneuro.7b00187
Autor:
Millie M. Georgiadis, Sandor Vajda, Mark R. Kelley, Hongzhen He, Dmitri Beglov, John A. Porco, Qiujia Chen, Richard Trilles, April Reed, Randall Wireman, Lauren E. Brown, Spandan Chennamadhavuni, James S. Panek
Publikováno v:
Journal of medicinal chemistry. 62(4)
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea787224b67753387f78cc6fdae4a87
https://pubmed.ncbi.nlm.nih.gov/30653918
https://pubmed.ncbi.nlm.nih.gov/30653918
Autor:
Nicole Robbins, Damian J. Krysan, Catherine A. McLellan, David S. Huang, Catherine S. Nation, Tanvi Shekhar-Guturja, Emmanuelle V. LeBlanc, Luke Whitesell, Ashley Hutchinson, Cathy Collins, John A. Porco, Raymond Hui, Leah E. Cowen, Richard Trilles, Utpal Tatu, Jinglin L. Xie, Lauren E. Brown, Juan C. Pizarro, Sharanya Chatterjee, Susan Lindquist
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
New strategies are needed to counter the escalating threat posed by drug-resistant fungi. The molecular chaperone Hsp90 affords a promising target because it supports survival, virulence and drug-resistance across diverse pathogens. Inhibitors of hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd06c64a48751b5a45513a82976781a8
https://igi.indrastra.com/items/show/195861
https://igi.indrastra.com/items/show/195861
Autor:
Scott E. Schaus, Ryan MacArthur, Lauren E. Brown, Rajarshi Guha, Melissa M. Dominguez, Aaron B. Beeler, Jing Yuan, Richard Trilles, Peng Dai, Ronald L. Johnson, Xin-zhuan Su, Ken Chih-Chien Cheng, Wanguo Wei, John K. Snyder, Pingwei Yuan, Feng Ni, John A. Porco, James Inglese
Publikováno v:
Proceedings of the National Academy of Sciences. 108:6775-6780
In an effort to expand the stereochemical and structural complexity of chemical libraries used in drug discovery, the Center for Chemical Methodology and Library Development at Boston University has established an infrastructure to translate methodol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf9fd7b25714ad0241e6ccf4944d9a
https://doi.org/10.1073/pnas.1017666108
https://doi.org/10.1073/pnas.1017666108