Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Richard Thorogate"'
Autor:
Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/8d84e8da21eb45a592eba0b8d3402fde
Autor:
Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Tau35 is a truncated form of tau found in human brain in a subset of tauopathies. Tau35 expression in mice recapitulates key features of human disease, including progressive increase in tau phosphorylation, along with cognitive and motor dysfunction.
Externí odkaz:
https://doaj.org/article/be685484133d4c3a8d3091c5db1f9df6
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The TAR DNA-binding protein 43 (TDP-43) is a nucleic acid-binding protein implicated in gene regulation and RNA processing and shuffling. It is a ribonuclear protein that carries out most of its functions by binding specific nucleic acid sequences wi
Externí odkaz:
https://doaj.org/article/1a610858909f416d8095d89d633f3ce4
Autor:
Jiajun, Luo, Shudong, Zhao, Xiangsheng, Gao, Swastina Nath, Varma, Wei, Xu, Maryam, Tamaddon, Richard, Thorogate, Haoran, Yu, Xin, Lu, Manuel, Salmeron-Sanchez, Chaozong, Liu
Publikováno v:
ACS applied materialsinterfaces. 14(30)
Nanotopography is an effective method to regulate cells' behaviors to improve Ti orthopaedic implants' in vivo performance. However, the mechanism underlying cellular matrix-nanotopography interactions that allows the modulation of cell adhesion has
Autor:
J. Sagar, Dominic Papineau, Martin Drost, Richard Thorogate, David Kilcoyne, Bradley T. De Gregorio, Larry R. Nittler, Geoff Thornton, Hubertus Marbach, Jianhua Wang
Publikováno v:
Journal of the Geological Society. 176:651-668
Metamorphism is thought to destroy microfossils, partly through devolatilization and graphitization of biogenic organic matter. However, the extent to which there is a loss of molecular, elemental and isotope signatures from biomass during high-tempe
Autor:
Alice L. B. Pyne, Liming Ying, Richard Thorogate, Matthew Reynolds, Beata Klejevskaja, Ramon Vilar, Bart W. Hoogenboom, Arun Shivalingam
Publikováno v:
Chemical Communications. 52:12454-12457
We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadrupl
Autor:
Francis, Brako, Richard, Thorogate, Suntharavathanan, Mahalingam, Bahijja, Raimi-Abraham, Duncan Q M, Craig, Mohan, Edirisinghe
Publikováno v:
ACS applied materialsinterfaces. 10(16)
Mucoadhesive delivery systems have attracted remarkable interest recently, especially for their potential to prolong dosage form resident times at sites of application such as the vagina or nasal cavity, thereby improving convenience and compliance a
Autor:
Carl Leung, Tilo Jankowski, Jake Stinson, Ute Drechsler, Richard Thorogate, Aizhan Bestembayeva, Jinling Yang, Martin Tschöpe, Bart W. Hoogenboom, Christian Marcovich, Alice L. B. Pyne, Michel Despont
Publikováno v:
Nano Letters. 12:3846-3850
Structural variability and flexibility are crucial factors for biomolecular function. Here we have reduced the invasiness and enhanced the spatial resolution of atomic force microscopy (AFM) to visualize, for the first time, different structural conf
Autor:
Katalin Török, Richard Thorogate
Publikováno v:
Journal of Cell Science. 117:5923-5936
Translocation from the cytosol to the nucleus is a major response by calmodulin (CaM) to stimulation of cells by Ca2+. However, the mechanisms involved in this process are still controversial and both passive and facilitated diffusion have been put f
Autor:
Alan R. Penheiter, Adelaida G. Filoteo, Richard Thorogate, Zeljko Bajzer, Katalin Török, Ariel J. Caride
Publikováno v:
Biochemistry. 42:12115-12124
Overexpression of the plasma membrane calcium pump (PMCA) isoform 4b by means of the baculovirus system enabled us, for the first time, to study the kinetics of calmodulin binding to this pump. This was done by stopped-flow fluorescence measurements