Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Richard Testar"'
Autor:
Lindsay Bawden, Deborah Brotherton, Vanessa L. Clark, Richard Testar, Mcdermott Joanne, David Festus Charles Moffat, Yvonne McGovern, Stéphane Pintat, Graham M. A. Wells, Alan Hastings Drummond, Sanjay R. Patel, Alan H. Davidson, Jo Owen, Stephen Davies, Sam Bryant, David Krige, Andrew J. Belfield, Valérie Legris, Lindsey Ann Needham, Elisabeth A. Bone, Francesca Ann Day, Michael Hugh Charlton, A. Donald
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 339:132-142
The therapeutic and toxic effects of drugs are often generated through effects on distinct cell types in the body. Selective delivery of drugs to specific cells or cell lineages would, therefore, have major advantages, in particular, the potential to
Autor:
Helen Mason, Simon Scrace, Richard Testar, Julie Rainard, Fatima Talab, Ryaka Poonawala, Philippa Smith, Harriet Brooke, Sarah Frith, Jonathan Ahmet, Jonathan Hall, David Sorrell, Jon Moore, Caroline Phillips, Dennis France, Matilda Bingham, Richard Armer
Publikováno v:
Cancer Research. 77:5160-5160
REDX05358 has been identified as a novel, highly selective and potent next generation pan RAF inhibitor with improved therapeutic potential and predicted safety profile. Aberrant signalling via the MAPK pathway is commonly seen in cancer. RAF inhibit
Autor:
Deborah H. Brotherton, Michael Hugh Charlton, Jo Owen, Richard Testar, Stephen Davies, David Festus Charles Moffat, Vanessa L. Clark
Publikováno v:
MedChemComm. 3:1070
Appending appropriate esters to anti-inflammatory compounds leads to monocyte/macrophage selectivity. This has been demonstrated in p38α MAP kinase in which we observe differential inhibition of phosphorylation of the substrate MAPKAPK2 in stimulate