Glioblastoma Multiforme Therapy and Mechanisms of Resistance

Autor: Yulian P. Ramirez, Jessica L. Weatherbee, Richard T. Wheelhouse, Alonzo H. Ross

Publikováno v: Pharmaceuticals, Vol 6, Iss 12, Pp 1475-1506 (2013)

Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The current standard of care, comprised of surgical resection followe

Externí odkaz: https://doaj.org/article/46257758f8f646419cc9d9a98ab6d631

Supplementary Figure Legends from Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

Autor: Jann N. Sakaria, Richard T. Wheelhouse, Alonzo H. Ross, Jarkko Rautio, Mikko Gynther, Roger M. Phillips, Ann C. Mladek, Yulian P. Ramirez

Legends for Supplementary Figures S1-S5.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2008589948c047711f1a08855ba858c4
https://doi.org/10.1158/1535-7163.22502496

Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

Autor: Christopher J. Moody, William Lewis, Magdalena B. Foreiter, Marc G. Hummersone, Richard T. Wheelhouse, Helen S. Summers, David Cousin, Tracey D. Bradshaw, Malcolm F. G. Stevens, Jihong Zhang

Publikováno v: MedChemComm. 9:545-553

A series of 3-(benzyl-substituted)-imidazo[5,1-d]-1,2,3,5-tetrazines (13) and related derivatives with 3-heteromethyl groups has been synthesised and screened for growth-inhibitory activity in vitro against two pairs of glioma cell lines with temozol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37dccf8e94ea21e104fc7ba2b4b0af63
https://doi.org/10.1039/c7md00554g

Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells

Autor: Robert A. Faulkner, Craig R. Rice, Owen J. Harper, Roger M. Phillips, David J. Cooke, Samantha L. Shepherd, Simon J. Allison, Richard T. Wheelhouse, Hollie B. S. Griffiths, Omar Khadeer Hussain, Paul I. P. Elliott, Francesca S. Davidson, P. Jane Owen-Lynch

Publikováno v: Allison, S J, Cooke, D, Davidson, F S, Elliott, P I P, Faulkner, R A, Griffiths, H B S, Harper, O, Hussain, O, Owen-Lynch, P J, Phillips, R M, Rice, C R, Shepherd, S L & Wheelhouse, R T 2018, ' Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells ', Angewandte Chemie-International Edition, vol. 57, no. 31, pp. 9799-9804 . https://doi.org/10.1002/anie.201805510

The ligands L1 and L2 both form separable dinuclear double-stranded helicate and mesocate complexes with RuII . In contrast to clinically approved platinates, the helicate isomer of [Ru2 (L1 )2 ]4+ was preferentially cytotoxic to isogenic cells (HCT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e9edece6e9c1a660ee5a318687a30e
https://pubmed.ncbi.nlm.nih.gov/29863754

Synthesis and growth-inhibitory activities of imidazo[5,1

Autor: David, Cousin, Marc G, Hummersone, Tracey D, Bradshaw, Jihong, Zhang, Christopher J, Moody, Magdalena B, Foreiter, Helen S, Summers, William, Lewis, Richard T, Wheelhouse, Malcolm F G, Stevens

Publikováno v: MedChemComm. 9(3)

The synthesis and biological evaluation of imidazotetrazines substituted at N-3 is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::731a25fcac8a5741d6beb1c8320ca201
https://pubmed.ncbi.nlm.nih.gov/30108945