Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Richard T. Walker"'
Autor:
Nicholas Dodds, Geldy Begenjev, Yevgeney Bezmenov, Christoph Gruetzner, Robert Mirzin, Edward Rhodes, Richard T. Walker, Paul Wordsworth
Publikováno v:
Bulletin of the Seismological Society of America. 112:2189-2215
The Main Köpetdag fault (MKDF) of Turkmenistan is one of the longest (≈500 km) and the most rapidly straining (9.1 ± 1.3 mm/yr) faults of the Arabia–Eurasia collision zone, and yet, in contrast to adjacent parts of Turkmenistan and Iran, it has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0173fb352e8808383d1f01b0ef7b18
https://doi.org/10.1785/0120210195
https://doi.org/10.1785/0120210195
Autor:
Richard T. Walker, Erik De Clercq, I. Basnak, Robert Snoeck, Annalisa Verri, Richard J. Duncombe, Federico Focher, Silvio Spadari, Graciela Andrei, Jan Balzarini, Paul L. Coe
Publikováno v:
Biochemical Journal. 351:319-326
The antiviral activity of several nucleoside analogues is often limited by their rapid degradation by pyrimidine nucleoside phosphorylases. In an attempt to avoid this degradation, several modified nucleosides have been synthesized. A series of 4´-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8231af459863ce034dbd0760440d6730
https://doi.org/10.1042/bj3510319
https://doi.org/10.1042/bj3510319
Publikováno v:
Nucleosides and Nucleotides. 18:181-186
Hydrolysis of adenine, guanine and cytosine 2′-deoxy-4′-thionucleosides in aqueous acid has been followed by HPLC. Stability of the compounds and mechanisms of hydrolysis are discussed in comparison with those of the corresponding native 2′-deo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3862e259f1f1d93bd2998c59931f911
https://doi.org/10.1080/15257779908043065
https://doi.org/10.1080/15257779908043065
Autor:
Li Wei-Zhong, I. Basnak, Yu Ming, Wang Jin-Ling, Richard T. Walker, T. A. Hamor, Miao Fang-Ming, Sun Ming
Publikováno v:
Acta Physico-Chimica Sinica. 15:834-837
substituted 6 aza 2' deoxyuridines are inhibitors of herps simplex virius type 1 thymidine kinase (HSV 1 TK). In this paper, the semiempirical self consistent field PM3 calculations have been undertaken for two typical HSV 1 TK inhibitors: compound (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8f74d73cc9feed9ca7abe4444aec1a0
https://doi.org/10.3866/pku.whxb19990912
https://doi.org/10.3866/pku.whxb19990912
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :335-340
Oxidation of 2′-deoxy-5-ethyl-4-thiouridine with sodium metaperiodate afforded a separable mixture of (R)- and (S)-sulfoxides. These were converted, after protection as their tert-butyldimethylsilyl ethers, by reaction with LDA to the 1′-anion wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a532894b6fe2ae39423605a759aa67
https://doi.org/10.1039/a807721e
https://doi.org/10.1039/a807721e
Publikováno v:
Tetrahedron. 54:12457-12464
Oxidation of 2′-deoxy-5-ethyl-4′-thiouridine with sodium meta-periodate yielded a separable mixture of (R) and(S)-sulfoxides. The structure of the (R)-sulfoxide was confirmed by X-ray analysis. When treated with sodium deuteroxide, the H-4′ pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f792ebff3f90863b59d403b9506283c
https://doi.org/10.1016/s0040-4020(98)00727-3
https://doi.org/10.1016/s0040-4020(98)00727-3
Autor:
Nigel B. Westwood, Richard T. Walker
Publikováno v:
Tetrahedron. 54:13391-13404
trans-4-hydroxy- L -proline (5) has been elaborated into a new series of pyrrolidine- L -nucleoside analogues incorporating non-standard 5-substituted-pyrimidine nucleobases, via the azidopyrrolidines 12 and 13. Those analogues employing an acyl prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58570f40c75786f40f927d39aeb23d95
https://doi.org/10.1016/s0040-4020(98)00821-7
https://doi.org/10.1016/s0040-4020(98)00821-7
Publikováno v:
Scopus-Elsevier
We report that a thymidine kinase (TK) activity is present in Trichomonas vaginalis and can be separated from the deoxyribonucleoside phosphotransferase. T. vaginalis TK, purified 11200-fold to apparent homogeneity, has a molecular mass of 31500 Da.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65c5bd17b8c35d0fdcd13030d1cd4d8
https://doi.org/10.1042/bj3340015
https://doi.org/10.1042/bj3340015
Autor:
Garry D. Jones, Karel D. Klika, Mikko Oivanen, Graham P. Otter, Alasdair C. MacCulloch, Richard T. Walker, Mohamed I. Elzagheid
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :2343-2350
The α and β anomers of 4′-thio-2′-deoxyuridine were readily synthesised as an anomeric mixture using adapted methodology and separated chromatographically as their 3′,5′-di-O-benzyl-N 3-benzoyl derivatives. The 5-fluoro analogs were prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9b95ba66de77620e1be80d55861a26
https://doi.org/10.1039/a806276e
https://doi.org/10.1039/a806276e