Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Richard T. Pon"'
Autor:
Jackie K. Zorz, Christine Sharp, Manuel Kleiner, Paul M. K. Gordon, Richard T. Pon, Xiaoli Dong, Marc Strous
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Alkaline lakes have some of the highest productivity rates in freshwater ecosystems. Here the authors report amplicon, metagenome, and proteome sequencing from microbial mat communities of four alkaline lakes in Canada, and compare these lakes to cen
Externí odkaz:
https://doaj.org/article/6c981e2cb8e8427c83bee701fe9a395e
Autor:
Richard T. Pon, Ryan E. Lamont, Uwe Wolfrum, Robert A. Hegele, Dan Doherty, Fiona Stewart, Martin McKibbin, Jay Shendure, Grischa Toedt, Colin E. Willoughby, Jillian S. Parboosingh, Clem Donahue, Kirsten A. Wunderlich, Lijia Huang, Marius Ueffing, Hannah M. Mitchison, Nasrin Sorusch, Teunis J. P. van Dam, Zakia Abdelhamed, Kym M. Boycott, Francois P. Bernier, Mohammed A. Aldahmesh, Subaashini Natarajan, Bernard N. Chodirker, Carole Ober, Julie Higgins, Matthew Adams, Darren C. Tomlinson, Hilary E. Racher, Thanh Minh T. Nguyen, Ian G. Phelps, Andreas Giessl, Katarzyna Szymanska, Ewan E. Morrison, Albert E. Chudley, Fowzan S. Alkuraya, Panagiotis I. Sergouniotis, Patrick Frosk, Jacquelyn Bond, Miriam Schmidts, Susanne Roosing, Nicola Horn, Gabrielle Wheway, Sandra M. Bell, Carmel Toomes, Toby J. Gibson, Martijn A. Huynen, Philip L. Beales, Gisela G. Slaats, Julie Kennedy, Clare V. Logan, Oliver E. Blacque, Paul M. K. Gordon, Rachel H. Giles, Heymut Omran, Aizeddin A. Mhanni, A. James Barkovich, David A. Parry, A. Micheil Innes, Dorus A. Mans, Jeroen van Reeuwijk, Kristin Kessler, Louis Wolf, Shamsa Anazi, Evan A. Boyle, Karsten Boldt, Ronald Roepman, Joseph G. Gleeson, Andrew R. Webster, Selwa A. Al Hazzaa, Chris F. Inglehearn, Warren Herridge, Christian Thiel, Chandree L. Beaulieu, Colin A. Johnson, Stef J.F. Letteboer
Publikováno v:
Nature cell biology
Nature Cell Biology, 17, 8, pp. 1074-87
Nature Cell Biology, 17, 1074-87
Nature Cell Biology, 17(8), 1074. Nature Publishing Group
Nature Cell Biology, 17, 8, pp. 1074-87
Nature Cell Biology, 17, 1074-87
Nature Cell Biology, 17(8), 1074. Nature Publishing Group
Item does not contain fulltext Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f0b712fcab169cef607b95c1a1e715
https://doi.org/10.1038/ncb3201
https://doi.org/10.1038/ncb3201
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:777-781
Small interfering RNAs (siRNA) are the latest candidates for oligonucleotide-based therapeutics. Should siRNA be successful in clinical trials, a huge demand for synthetic RNA is anticipated. We believe that 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d46ce3d798e3e432d67008dcb2b80b
https://doi.org/10.1081/ncn-200060150
https://doi.org/10.1081/ncn-200060150
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2003, 22 (5-8), pp.653-658. ⟨10.1081/NCN-120022604⟩
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2003, 22 (5-8), pp.653-658. ⟨10.1081/NCN-120022604⟩
International audience; Nucleoside analogs such as 1-beta-D-arabinofuranosyl cytidine (AraC) and 2',2'-difluoro deoxycytidine (dFdC) are important components of the anticancer chemotherapeutic arsenal and are among the most effective anticancer drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cfd898ce28c971333a73cab255e0be
https://doi.org/10.1081/ncn-120022604
https://doi.org/10.1081/ncn-120022604
Publikováno v:
The Journal of Organic Chemistry. 67:856-864
More than one oligonucleotide can be synthesized at a time by linking multiple oligonucleotides end-to-end in a tandem manner on the surface of a solid-phase support. The 5'-terminal hydroxyl position of one oligonucleotide serves as the starting poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fceeac145d0e672c4c2b61b07a5623a
https://doi.org/10.1021/jo0160773
https://doi.org/10.1021/jo0160773
Autor:
Richard T. Pon, Shuyuan Yu
Publikováno v:
Tetrahedron Letters. 42:8943-8946
Linker phosphoramidite reagents containing a protected nucleoside with a cleavable 3′-ester linkage to either succinic acid, diglycolic acid, or hydroquinone-O,O′-diacetic acid (Q-Linker) allow the 3′-terminal nucleoside of an oligonucleotide s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e82788ba5ff9ecc0c0a7709c1a5d80f
https://doi.org/10.1016/s0040-4039(01)01996-7
https://doi.org/10.1016/s0040-4039(01)01996-7
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2638-2643
A general method for oligonucleotide synthesis on reusable solid-phase supports has been developed which will significantly lower the cost of large-scale synthesis. It consists of five steps: 1, nucleoside attachment to an hydroxy derivatized support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b8a0c1b843e88072e72fb733ccfe1f
https://doi.org/10.1039/b105089n
https://doi.org/10.1039/b105089n
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:985-989
Multiple oligonucleotides linked end-to-end in tandem can be synthesized by adding a nucleoside to the 5'-OH end of a prior sequence. Nucleosides with 3'-succinyl or Q-Linker arms are coupled with HBTU/DMAP. Alternatively, new phosphoramidite reagent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315483e3de7fc41b776742a2e3029a7c
https://doi.org/10.1081/ncn-100002474
https://doi.org/10.1081/ncn-100002474
Publikováno v:
Bioconjugate Chemistry. 11:282-288
A novel combinatorial approach to synthesize oligonucleotides on fluorescently encoded microspheres based on flow sorting and segmental solid-phase synthesis is described. BODIPY dyes were covalently attached to polystyrene (8.8 microm, 55% DVB) micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6a39462462493b664e4731cb78cf15
https://doi.org/10.1021/bc990145z
https://doi.org/10.1021/bc990145z
Autor:
Ryan E. Lamont, Jillian S. Parboosingh, L. Dimnik, U. Sajid, V. Suresh, Steven C. Greenway, Paul M. K. Gordon, N. Chang, Debra Isaac, Richard T. Pon
Publikováno v:
The Journal of Heart and Lung Transplantation. 34:S329-S330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eccc55fa9ae5fce123fe5f891a030c5a
https://doi.org/10.1016/j.healun.2015.01.936
https://doi.org/10.1016/j.healun.2015.01.936