Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Richard T. Libby"'
Autor:
Cory A. Diemler, Michael MacLean, Sarah E. Heuer, Amanda A. Hewes, Olivia J. Marola, Richard T. Libby, Gareth R. Howell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
In recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. To better understand the role of microglia during chronic ocular hypertension, we depleted microglia from aged (9–12 months ol
Externí odkaz:
https://doaj.org/article/6b27b539c39343098b06fa8d8c1711f0
Autor:
Margaret E. Maes, Ryan J. Donahue, Cassandra L. Schlamp, Olivia J. Marola, Richard T. Libby, Robert W. Nickells
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the mitochondrial outer membrane (MOM) and then pe
Externí odkaz:
https://doaj.org/article/7657e4fe09f54146a892dfbcaf469f51
Autor:
Xiaowei Wang, Christine Delle, Weiguo Peng, Virginia Plá, Michael Giannetto, Peter Kusk, Björn Sigurdsson, Shinya Sakurai, Amanda Sweeney, Qian Sun, Ting Du, Richard T. Libby, Maiken Nedergaard
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106322- (2023)
The ocular glymphatic system supports bidirectional fluid transport along the optic nerve, thereby removes metabolic wastes including amyloid-β. To better understand this biological process, we examined the distributions of intravitreally and intrac
Externí odkaz:
https://doaj.org/article/106caf26e0484bc3b434466aa008f99e
Autor:
Olivia J. Marola, Sarah E. R. Yablonski, Peter G. Shrager, Robert W. Nickells, Richard T. Libby
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/eb892c47a1154f999d3036c99161ddab
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Endothelin (EDN, also known as ET) signaling has been suggested to be an important mediator of retinal ganglion cell (RGC) death in glaucoma. Antagonism of EDN receptors (EDNRA and EDNRB, also known as ET-A and ET-B) prevented RGC death in m
Externí odkaz:
https://doaj.org/article/83fc65d8bc674c709d199ae6406aeed7
Autor:
Stephanie B. Syc-Mazurek, Hongtian Stanley Yang, Olivia J. Marola, Gareth R. Howell, Richard T. Libby
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-12 (2022)
Abstract Injury to the axons of retinal ganglion cells (RGCs) is a key pathological event in glaucomatous neurodegeneration. The transcription factors JUN (the target of the c-Jun N-terminal kinases, JNKs) and DDIT3/CHOP (a mediator of the endoplasmi
Externí odkaz:
https://doaj.org/article/02438d6908a94953b196ae00e8d3a4ee
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Excitotoxicity leads to the activation of a cytotoxic cascade that causes neuronal death. In the retina, retinal ganglion cells (RGCs) die after an excitotoxic insult. Multiple pathways have been proposed to contribute to RGC death after an
Externí odkaz:
https://doaj.org/article/83317f3ff5434210b4ad64e85fa607aa
Autor:
Stephanie B. Syc-Mazurek, Kimberly A. Fernandes, Michael P. Wilson, Peter Shrager, Richard T. Libby
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-13 (2017)
Abstract Background Optic nerve injury is an important pathological component in neurodegenerative diseases such as traumatic optic neuropathies and glaucoma. The molecular signaling pathway(s) critical for retinal ganglion cell (RGC) death after axo
Externí odkaz:
https://doaj.org/article/193b548d134f4fd5ac48c960d8cbb1d2
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 108-116 (2014)
Injury to retinal ganglion cell (RGC) axons triggers rapid activation of Jun N-terminal kinase (JNK) signaling, a major prodeath pathway in injured RGCs. Of the multiple kinases that can activate JNK, dual leucine kinase (Dlk) is known to regulate bo
Externí odkaz:
https://doaj.org/article/029c81c4ee19431588427ddeb17b1a9a
Autor:
Kimberly A. Fernandes, Jeffrey M. Harder, Laura B. Fornarola, Robert S. Freeman, Abbot F. Clark, Iok-Hou Pang, Simon W.M. John, Richard T. Libby
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 2, Pp 393-401 (2012)
Glaucoma is a neurodegenerative disease characterized by the apoptotic death of retinal ganglion cells (RGCs). The primary insult to RGCs in glaucoma is thought to occur to their axons as they exit the eye in the optic nerve head. However, pathologic
Externí odkaz:
https://doaj.org/article/1fcb64a2048241429e4938ae34550e85