Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Richard T. Bryan"'
Autor:
Naheema S. Gordon, Elspeth K. McGuigan, Michaela Ondasova, Jennifer Knight, Laura A. Baxter, Sascha Ott, Robert K. Hastings, Maurice P. Zeegers, Nicholas D. James, K. K. Cheng, Anshita Goel, Minghao Yu, Roland Arnold, Richard T. Bryan, Douglas G. Ward
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-4 (2024)
Abstract Background and aims Several non-invasive tests for detecting bladder cancer (BC) are commercially available and are based on detecting small panels of BC-associated mutations and/or methylation changes in urine DNA. However, it is not clear
Externí odkaz:
https://doaj.org/article/948476a9f2e2449e9f9c0f8d0705374d
Autor:
Iliana K. Kerzeli, Alexandros Kostakis, Polat Türker, Per-Uno Malmström, Tammer Hemdan, Artur Mezheyeuski, Douglas G. Ward, Richard T. Bryan, Ulrika Segersten, Martin Lord, Sara M. Mangsbo
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Urothelial bladder cancer is most frequently diagnosed at the non-muscle-invasive stage (NMIBC). However, recurrences and interventions for intermediate and high-risk NMIBC patients impact the quality of life. Biomarkers for patie
Externí odkaz:
https://doaj.org/article/92d29f31336b4424a72603475b46d14c
Autor:
Anshita Goel, Douglas G. Ward, Boris Noyvert, Minghao Yu, Naheema S. Gordon, Ben Abbotts, John K. Colbourne, Stephen Kissane, Nicholas D. James, Maurice P. Zeegers, Kar Keung Cheng, Jean-Baptiste Cazier, Celina M. Whalley, Andrew D. Beggs, Claire Palles, Roland Arnold, Richard T. Bryan
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background Three-quarters of bladder cancer patients present with early-stage disease (non-muscle-invasive bladder cancer, NMIBC, UICC TNM stages Ta, T1 and Tis); however, most next-generation sequencing studies to date have concentrated on
Externí odkaz:
https://doaj.org/article/d1aa928db1214c45b71b986bd13f2d0c
Autor:
Beth Russell, Sarah Spencer‐Bowdage, Jeannie Rigby, Jackie O'Kelly, Phil Kelly, Mark Page, Caroline Raw, Paula Allchorne, Peter Harper, Jeremy Crew, Roger Kockelbergh, Allen Knight, Mieke Van Hemelrijck, Richard T. Bryan
Publikováno v:
BJUI Compass, Vol 3, Iss 5, Pp 324-326 (2022)
Externí odkaz:
https://doaj.org/article/cd3b9f08e81444599466d86c099ba7e5
Autor:
Naheema S. Gordon, Nada Humayun-Zakaria, Anshita Goel, Ben Abbotts, Maurice P. Zeegers, K.K. Cheng, Nicholas D. James, Roland Arnold, Richard T. Bryan, Douglas G. Ward
Publikováno v:
European Urology Open Science, Vol 38, Iss , Pp 88-95 (2022)
Background: Mutations in STAG2 cause complete loss of STAG2 protein in approximately one-third of non–muscle-invasive bladder cancers (NMIBCs). STAG2 protein expression is easily determined via immunohistochemistry (IHC) and published data suggest
Externí odkaz:
https://doaj.org/article/cd7f6e392dac489ca6158fd808a151a1
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
IntroductionNon-muscle-invasive bladder cancer (NMIBC) is a common and heterogeneous disease; many patients develop recurrent or progress to muscle-invasive disease. Intravesical drug therapy is a pillar in the current management of NMIBC; notwithsta
Externí odkaz:
https://doaj.org/article/d067ec214d1c46ac894c92ebf516ab3b
Autor:
Sia Viborg Lindskrog, Frederik Prip, Philippe Lamy, Ann Taber, Clarice S. Groeneveld, Karin Birkenkamp-Demtröder, Jørgen Bjerggaard Jensen, Trine Strandgaard, Iver Nordentoft, Emil Christensen, Mateo Sokac, Nicolai J. Birkbak, Lasse Maretty, Gregers G. Hermann, Astrid C. Petersen, Veronika Weyerer, Marc-Oliver Grimm, Marcus Horstmann, Gottfrid Sjödahl, Mattias Höglund, Torben Steiniche, Karin Mogensen, Aurélien de Reyniès, Roman Nawroth, Brian Jordan, Xiaoqi Lin, Dejan Dragicevic, Douglas G. Ward, Anshita Goel, Carolyn D. Hurst, Jay D. Raman, Joshua I. Warrick, Ulrika Segersten, Danijel Sikic, Kim E. M. van Kessel, Tobias Maurer, Joshua J. Meeks, David J. DeGraff, Richard T. Bryan, Margaret A. Knowles, Tatjana Simic, Arndt Hartmann, Ellen C. Zwarthoff, Per-Uno Malmström, Núria Malats, Francisco X. Real, Lars Dyrskjøt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated
Externí odkaz:
https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d
Autor:
Harriet P. Mintz, Amandeep Dosanjh, Helen M. Parsons, Ana Hughes, Alicia Jakeman, Ann M. Pope, Richard T. Bryan, the BladderPath trial management group, Nicholas D. James, Prashant Patel
Publikováno v:
Pilot and Feasibility Studies, Vol 6, Iss 1, Pp 1-12 (2020)
Abstract Background Bladder cancer outcomes have not changed significantly in 30 years; the BladderPath trial (Image Directed Redesign of Bladder Cancer Treatment Pathway, ISRCTN35296862) proposes to evaluate a modified pathway for diagnosis and trea
Externí odkaz:
https://doaj.org/article/665ec00a4a584208bd9bc9a1f0094fad
Autor:
Rebecca Lewis, Rachel Todd, Michelle Newton, Robert J. Jones, Caroline Wilson, Jenny L. Donovan, Richard T. Bryan, Alison Birtle, Emma Hall, on behalf of the POUT Trial Management Group
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background The utility of patient screening logs and their impact on improving trial recruitment rates are unclear. We conducted a retrospective exploratory analysis of screening data collected within a multicentre randomised controlled tria
Externí odkaz:
https://doaj.org/article/849dd23ec95f487e856a289773534c50
Autor:
Alexander C. Dowell, Haydn Munford, Anshita Goel, Naheema S. Gordon, Nicholas D. James, K. K. Cheng, Maurice P. Zeegers, Douglas G. Ward, Richard T. Bryan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The use of immune checkpoint blockade, in particular PD-1 and PD-L1 inhibitors, is now commonplace in many clinical settings including the treatment of muscle-invasive bladder cancer (MIBC). Notwithstanding, little information exists regarding the ex
Externí odkaz:
https://doaj.org/article/a6407fd65c5047b08c56e5b712248dad