Výsledky vyhledávání - "Richard T Premont"

Akademický článek

GIT1 regulates synaptic structural plasticity underlying learning.

Autor: Amanda C Martyn, Krisztian Toth, Robert Schmalzigaug, Nathan G Hedrick, Ramona M Rodriguiz, Ryohei Yasuda, William C Wetsel, Richard T Premont

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194350 (2018)

The signaling scaffold protein GIT1 is expressed widely throughout the brain, but its function in vivo remains elusive. Mice lacking GIT1 have been proposed as a model for attention deficit-hyperactivity disorder, due to alterations in basal locomoto

Externí odkaz: https://doaj.org/article/40a0aacba1ec4d478275acafdc3fda0d

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Akademický článek

GIT2 acts as a systems-level coordinator of neurometabolic activity and pathophysiological aging

Autor: Bronwen eMartin, Jonathan eJanssens, Wayne eChadwick, Richard T Premont, Robert eSchmalzigaug, Kevin G Becker, Elin eLehrmann, William H Wood, Yongqing eZhang, Sana eSiddiqui, Sung-Soo ePark, Wei-na eCong, Caitlin M Daimon, Stuart eMaudsley

Publikováno v: Frontiers in Endocrinology, Vol 6 (2016)

Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. Th

Externí odkaz: https://doaj.org/article/4280a9226787474897f6982e9e419d02

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Akademický článek

Activation of hepatic acetyl-CoA carboxylase by S-nitrosylation in response to diet

Autor: Nicholas M. Venetos, Colin T. Stomberski, Zhaoxia Qian, Richard T. Premont, Jonathan S. Stamler

Publikováno v: Journal of Lipid Research, Vol 65, Iss 5, Pp 100542- (2024)

Nitric oxide (NO), produced primarily by nitric oxide synthase enzymes, is known to influence energy metabolism by stimulating fat uptake and oxidation. The effects of NO on de novo lipogenesis (DNL), however, are less clear. Here we demonstrate that

Externí odkaz: https://doaj.org/article/3cc03f53e51e45339f1a1a0980076d37

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Akademický článek

Protocol for preparing Thiopropyl Sepharose resin used for capturing S-nitrosylated proteins

Autor: Puneet Seth, Alfred Hausladen, Richard T. Premont, Jonathan S. Stamler

Publikováno v: STAR Protocols, Vol 4, Iss 4, Pp 102430- (2023)

Summary: S-nitrosothiol (SNO)-Resin Assisted Capture (SNO-RAC) relies on a Thiopropyl Sepharose resin to identify S-nitrosylated proteins (SNO-proteins) and sites of S-nitrosylation. Here, we present a protocol for preparing Thiopropyl Sepharose resi

Externí odkaz: https://doaj.org/article/326719b1f07647af88ef334e100a4cfc

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Akademický článek

Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation

Autor: Rongli Zhang, Alfred Hausladen, Zhaoxia Qian, Xudong Liao, Richard T. Premont, Jonathan S. Stamler

Publikováno v: JCI Insight, Vol 7, Iss 3 (2022)

Systemic hypoxia is characterized by peripheral vasodilation and pulmonary vasoconstriction. However, the system-wide mechanism for signaling hypoxia remains unknown. Accumulating evidence suggests that hemoglobin (Hb) in RBCs may serve as an O2 sens

Externí odkaz: https://doaj.org/article/65ec0b327e2144c8a3a56c4409e37220

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Akademický článek

An optimized protocol for isolation of S-nitrosylated proteins from C. elegans

Autor: Puneet Seth, Richard T. Premont, Jonathan S. Stamler

Publikováno v: STAR Protocols, Vol 2, Iss 2, Pp 100547- (2021)

Summary: Post-translational modification by S-nitrosylation regulates numerous cellular functions and impacts most proteins across phylogeny. We describe a protocol for isolating S-nitrosylated proteins (SNO-proteins) from C. elegans, suitable for as

Externí odkaz: https://doaj.org/article/53735b47ff124f3a8cab49ba24758e9a

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