Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Richard T Premont"'
Autor:
Nicholas M. Venetos, Colin T. Stomberski, Zhaoxia Qian, Richard T. Premont, Jonathan S. Stamler
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 5, Pp 100542- (2024)
Nitric oxide (NO), produced primarily by nitric oxide synthase enzymes, is known to influence energy metabolism by stimulating fat uptake and oxidation. The effects of NO on de novo lipogenesis (DNL), however, are less clear. Here we demonstrate that
Externí odkaz:
https://doaj.org/article/3cc03f53e51e45339f1a1a0980076d37
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102430- (2023)
Summary: S-nitrosothiol (SNO)-Resin Assisted Capture (SNO-RAC) relies on a Thiopropyl Sepharose resin to identify S-nitrosylated proteins (SNO-proteins) and sites of S-nitrosylation. Here, we present a protocol for preparing Thiopropyl Sepharose resi
Externí odkaz:
https://doaj.org/article/326719b1f07647af88ef334e100a4cfc
Autor:
Kuo Du, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, Susanna Naggie, Cynthia A. Moylan, Mustafa R. Bashir, Manal F. Abdelmalek, Anna Mae Diehl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Background & Aims: Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in mice. However, it is unclear how cha
Externí odkaz:
https://doaj.org/article/2913df394d7c4f06abb93625a9bfe0c6
Autor:
Rongli Zhang, Alfred Hausladen, Zhaoxia Qian, Xudong Liao, Richard T. Premont, Jonathan S. Stamler
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Systemic hypoxia is characterized by peripheral vasodilation and pulmonary vasoconstriction. However, the system-wide mechanism for signaling hypoxia remains unknown. Accumulating evidence suggests that hemoglobin (Hb) in RBCs may serve as an O2 sens
Externí odkaz:
https://doaj.org/article/65ec0b327e2144c8a3a56c4409e37220
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100547- (2021)
Summary: Post-translational modification by S-nitrosylation regulates numerous cellular functions and impacts most proteins across phylogeny. We describe a protocol for isolating S-nitrosylated proteins (SNO-proteins) from C. elegans, suitable for as
Externí odkaz:
https://doaj.org/article/53735b47ff124f3a8cab49ba24758e9a
Autor:
Hua-Lin Zhou, Alfred Hausladen, Puneet Anand, Malligarjunan Rajavel, Colin T. Stomberski, Rongli Zhang, Richard T. Premont, William J. Greenlee, Focco van den Akker, Jonathan S. Stamler
Publikováno v:
Journal of Medicinal Chemistry. 66:5657-5668
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8a4cb7b1dbbe05bf149528ba3752d7
https://doi.org/10.1021/acs.jmedchem.2c02089
https://doi.org/10.1021/acs.jmedchem.2c02089
Autor:
Julian Gerhards, Lars D. Maerz, Edda S. F. Matthees, Cornelia Donow, Barbara Moepps, Richard T. Premont, Martin D. Burkhalter, Carsten Hoffmann, Melanie Philipp
Publikováno v:
Journal of the American Society of Nephrology. 34:590-606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b286a9d92b9a93a0d87a88603dbdf225
https://doi.org/10.1681/asn.0000000000000082
https://doi.org/10.1681/asn.0000000000000082
Autor:
Sihyung Wang, Youngmi Jung, Jeongeun Hyun, Matthew Friedersdorf, Seh-Hoon Oh, Jieun Kim, Richard T. Premont, Jack D. Keene, Anna Mae Diehl
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 3, Pp 1215-1229 (2018)
Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of MF-HSC populations, eff
Externí odkaz:
https://doaj.org/article/79865b208d884ea78ffe5ee0a26e1ad6
Autor:
Guanhua Xie, Marzena Swiderska-Syn, Mark L. Jewell, Mariana Verdelho Machado, Gregory A. Michelotti, Richard T. Premont, Anna Mae Diehl
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy availability at the cellul
Externí odkaz:
https://doaj.org/article/70df0e0af0644f11afbd602365a23c5f
Autor:
Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Paula Santos-Otte, Richard T. Premont, Bronwen Martin, Stuart Maudsley
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Complex aging-triggered disorders are multifactorial programs that comprise a myriad of alterations in interconnected protein networks over a broad range of tissues. It is evident that rather than being randomly organized events, pathophysiologies th
Externí odkaz:
https://doaj.org/article/f635c04819c3414ea22a3db24130869d