Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Richard T Kloos"'
Autor:
Jessica O. Pinto, Masha J. Livhits, Michael W. Yeh, Atanas Kaykov, Joshua P. Klopper, Richard T. Kloos, Mohammed Alshalalfa, Yangyang Hao, Jing Huang, Mayumi Endo
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 35, Iss , Pp 100329- (2024)
Objective: The objective of this study was to analyze the risk of malignancy and the histopathology of telomerase reverse transcriptase promoter (TERT) mutated cytologically indeterminate thyroid nodules (ITN). Methods: A PUBMED search of molecularly
Externí odkaz:
https://doaj.org/article/9888a632ae694c73978a0adc534adbd7
Autor:
Dorota Whitmer, John E. Phay, Shelby Holt, Benjamin O’Donnell, Jay Nguyen, Dennis Joseph, Anthony Chi, Shuyang Wu, Yangyang Hao, Jing Huang, Joshua P. Klopper, Richard T. Kloos, Giulia C. Kennedy, Joyce Shin
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectivesTo evaluate the frequency and risk of malignancy of TSHRpI568T mutations discovered in indeterminate thyroid nodules (ITN) within the Veracyte CLIA laboratory undergoing Afirma® Genomic Sequencing Classifier (GSC) testing, and to evaluate
Externí odkaz:
https://doaj.org/article/b4fd7c23e2e14b2ea15fab429cacb8d9
Autor:
P. Sean Walsh, Yangyang Hao, Jie Ding, Jianghan Qu, Jonathan Wilde, Ruochen Jiang, Richard T. Kloos, Jing Huang, Giulia C. Kennedy
Publikováno v:
Journal of Personalized Medicine, Vol 13, Iss 1, p 24 (2022)
Despite its wide-ranging benefits, whole-transcriptome or RNA exome profiling is challenging to implement in a clinical diagnostic setting. The Unified Assay is a comprehensive workflow wherein exome-enriched RNA-sequencing (RNA-Seq) assays are perfo
Externí odkaz:
https://doaj.org/article/7638630365ac478795e4e05651b57700
Autor:
Christian E Nasr, Massimiliano Andrioli, Mayumi Endo, R Mack Harrell, Masha J Livhits, Ibitoro Osakwe, Preethi Polavarapu, Allan Siperstein, Shuanzeng Wei, Xingyu Zheng, Ruochen Jiang, Yangyang Hao, J I ng Huang, Joshua P Klopper, Richard T Kloos, Giulia Kennedy, Trevor E Angell
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 108:1526-1532
Context The Afirma® GSC aids in risk stratifying indeterminate thyroid nodule cytology (ITN). The 2018 GSC validation study (VS) reported a sensitivity (SN) of 91%, specificity (SP) of 68%, positive predictive value (PPV) of 47%, and negative predic
Autor:
Gregory W. Randolph, Julie Ann Sosa, Yangyang Hao, Trevor E. Angell, David C. Shonka, Virginia A. LiVolsi, Paul W. Ladenson, Thomas C. Blevins, Quan-Yang Duh, Ronald Ghossein, Mack Harrell, Kepal Narendra Patel, Michael H. Shanik, S. Thomas Traweek, P. Sean Walsh, Michael W. Yeh, Amr H. Abdelhamid Ahmed, Allen S. Ho, Richard J. Wong, Joshua P. Klopper, Jing Huang, Giulia C. Kennedy, Richard T. Kloos, Peter M. Sadow
Publikováno v:
Thyroid : official journal of the American Thyroid Association, vol 32, iss 9
Background: Cytopathological evaluation of thyroid fine-needle aspiration biopsy (FNAB) specimens can fail to raise preoperative suspicion of medullary thyroid carcinoma (MTC). The Afirma RNA-sequencing MTC classifier identifies MTC among FNA samples
Autor:
Trevor E. Angell, Lori J. Wirth, Maria E. Cabanillas, Maisie L. Shindo, Edmund S. Cibas, Joshua E. Babiarz, Yangyang Hao, Su Yeon Kim, P. Sean Walsh, Jing Huang, Richard T. Kloos, Giulia C. Kennedy, Steven G. Waguespack
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Introduction: The Afirma® Xpression Atlas (XA) detects gene variants and fusions in thyroid nodule FNA samples from a curated panel of 511 genes using whole-transcriptome RNA-sequencing. Its intended use is among cytologically indeterminate nodules
Externí odkaz:
https://doaj.org/article/16a3057bc68d49a89d85ac502ac22e81
Autor:
Yangyang Hao, Yoonha Choi, Joshua E. Babiarz, Richard T. Kloos, Giulia C. Kennedy, Jing Huang, P. Sean Walsh
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Background: Fine needle aspiration (FNA) cytology, a diagnostic test central to thyroid nodule management, may yield indeterminate results in up to 30% of cases. The Afirma® Genomic Sequencing Classifier (GSC) was developed and clinically validated
Externí odkaz:
https://doaj.org/article/f5269ffa52434dd88483653a6b83aae0
Autor:
Mark Zafereo, Chrysoula Dosiou, Giulia C. Kennedy, Yangyang Hao, Lori J. Wirth, Steven P. Weitzman, Joshua E. Babiarz, Richard T. Kloos, Mimi I. Hu, Syed Z. Ali, Peter M. Sadow, Brendan C. Stack, Jeffrey F. Krane, Steven G. Waguespack, Paul W. Ladenson, Masha J. Livhits
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 106:2198-2207
Context Broad genomic analyses among thyroid histologies have been described from relatively small cohorts. Objective Investigate the molecular findings across a large, real-world cohort of thyroid fine-needle aspiration (FNA) samples. Design Retrosp
Autor:
Christian E Nasr, Massimiliano Andriol, Mayumi Endo, R Mack Harrell, Masha J Livhits, Ibitoro Osakwe, Preethi Polavarapu, Shuanzeng Wei, Xingyu Zheng, Ruochen Jiang, Yangyang Hao, JIng Huang, Joshua P Kloppe, Richard T Kloos, Giulia Kennedy, Trevor E Angell
Publikováno v:
Journal of the Endocrine Society. 6:A745-A746
The Afirma GSC aids in the clinical decision making for patients with indeterminate thyroid nodule cytology (ITN). The 2018 GSC validation study was a prospective, multi-center study, conducted on a patient cohort with ITN. All patients underwent sur
Autor:
Wim J.G. Oyen, Richard T. Kloos, Bennett Greenspan, Jacqueline Jonklaas, R. Michael Tuttle, Anca M. Avram, Johannes W. A. Smit, Frederick D. Grant, Luca Giovanella, Laszlo Hegedüs, Ciprian Draganescu, Seza A. Gulec, Victor Bernet, Sukhjeet Ahuja, Markus Luster, Patrick Bourguet, R. Elisei
Publikováno v:
Thyroid, 31, 7, pp. 1009-1019
Thyroid, 31, 1009-1019
Gulec, S A, Ahuja, S, Avram, A M, Bernet, V J, Bourguet, P, Draganescu, C, Elisei, R, Giovanella, L, Grant, F, Greenspan, B, Hegedüs, L, Jonklaas, J, Kloos, R T, Luster, M, Oyen, W J G, Smit, J & Tuttle, R M 2021, ' A Joint Statement from the American Thyroid Association, the European Association of Nuclear Medicine, the European Thyroid Association, the Society of Nuclear Medicine and Molecular Imaging on Current Diagnostic and Theranostic Approaches in the Management of Thyroid Cancer ', Thyroid, vol. 31, no. 7, pp. 1009-1019 . https://doi.org/10.1089/thy.2020.0826
Thyroid, 31, 1009-1019
Gulec, S A, Ahuja, S, Avram, A M, Bernet, V J, Bourguet, P, Draganescu, C, Elisei, R, Giovanella, L, Grant, F, Greenspan, B, Hegedüs, L, Jonklaas, J, Kloos, R T, Luster, M, Oyen, W J G, Smit, J & Tuttle, R M 2021, ' A Joint Statement from the American Thyroid Association, the European Association of Nuclear Medicine, the European Thyroid Association, the Society of Nuclear Medicine and Molecular Imaging on Current Diagnostic and Theranostic Approaches in the Management of Thyroid Cancer ', Thyroid, vol. 31, no. 7, pp. 1009-1019 . https://doi.org/10.1089/thy.2020.0826
Item does not contain fulltext Background: The American Thyroid Association (ATA), the European Association of Nuclear Medicine, the European Thyroid Association, and the Society of Nuclear Medicine and Molecular Imaging have established an intersoci