Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Richard T, Roberts"'
Autor:
Jaehyeon Park, Harlan F Reese, Yun-Chou Tan, Hasim Zecic, Martin Stahl, Keshab Sarma, Renee Litman, Alejandra Trejo, William Bingenheimer, Michael Soth, David Michael Goldstein, Mary Welch, Eric Brian Sjogren, Man-Ling Sung, Sandra Frauchiger, Nolan James Dewdney, Bong San Pablo, Eva Papp, Daniel McWeeney, Ronald J. Hill, Paul Weller, Manjiri Ghate, JoAnn La Fargue, Brian Wong, Stacie A. Dalrymple, James Patrick Dunn, David Mark Rotstein, Richard T. Roberts, Bradford Graves, Rebecca T Suttman, Mcintosh Joel, Farrell Robert P, Andreas Kuglstatter, Chen Jian Jeffrey, Fujun Li, Humberto Bartolome Arzeno, Brad Loe, Tobias Gabriel
Publikováno v:
Journal of Medicinal Chemistry. 54:2255-2265
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdfa3e0a0a96eaca0eea2feab67e249
https://doi.org/10.1021/jm101423y
https://doi.org/10.1021/jm101423y
Autor:
Yong-Nam Kim, Stanford L. Peng, Anthony M. Manning, Joseph Dal Porto, Karim Dabbagh, Ronald J. Hill, Mary Welch, Kyung Song, Tanja S. Zabka, Ching Li, Dee Aud, Rebecca Suttmann, David Leaffer, Kung-ching Chang, Eva Papp, Brian Wong, Deborah Phippard, David Michael Goldstein, Richard T. Roberts
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 327:610-619
P38alpha is a protein kinase that regulates the expression of inflammatory cytokines, suggesting a role in the pathogenesis of diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Here, we describe the preclinical pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5502518251ceeb1bab20275edd3fd6e3
https://doi.org/10.1124/jpet.108.139006
https://doi.org/10.1124/jpet.108.139006
Autor:
David M, Goldstein, Michael, Soth, Tobias, Gabriel, Nolan, Dewdney, Andreas, Kuglstatter, Humberto, Arzeno, Jeffrey, Chen, William, Bingenheimer, Stacie A, Dalrymple, James, Dunn, Robert, Farrell, Sandra, Frauchiger, JoAnn, La Fargue, Manjiri, Ghate, Bradford, Graves, Ronald J, Hill, Fujun, Li, Renee, Litman, Brad, Loe, Joel, McIntosh, Daniel, McWeeney, Eva, Papp, Jaehyeon, Park, Harlan F, Reese, Richard T, Roberts, David, Rotstein, Bong, San Pablo, Keshab, Sarma, Martin, Stahl, Man-Ling, Sung, Rebecca T, Suttman, Eric B, Sjogren, Yunchou, Tan, Alejandra, Trejo, Mary, Welch, Paul, Weller, Brian R, Wong, Hasim, Zecic
Publikováno v:
Journal of medicinal chemistry. 54(7)
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda31600d6054cc75ed83ea768d5f392
https://pubmed.ncbi.nlm.nih.gov/21375264
https://pubmed.ncbi.nlm.nih.gov/21375264
Autor:
Richard T. Roberts, Brian W. Pfennig
Publikováno v:
Journal of Chemical Education. 83:1804
A chemical demonstration of a clock reaction involving red and green colors for the winter holiday season is reported. The system consists of oxidation–reduction reactions involving iodate, sulfite, and thiosulfate that experiences a large-amplitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b183a8394785d01435bee3aa87dd5ecc
https://doi.org/10.1021/ed083p1804
https://doi.org/10.1021/ed083p1804
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