Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Richard T, Mathias"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The lens is an avascular organ that is supported by an internal circulation of water and solutes. This circulation is driven by ion pumps, channels and transporters in epithelial cells and by ion channels in fiber cells and is maintained by fiber-fib
Externí odkaz:
https://doaj.org/article/d3b0dda7798c48c3a6d8d15ca8483ca6
Autor:
Rupalatha Maddala, Junyuan Gao, Richard T. Mathias, Tylor R. Lewis, Vadim Y. Arshavsky, Adriana Levine, Jonathan M. Backer, Anne R. Bresnick, Ponugoti V. Rao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract S100A4, a member of the S100 family of multifunctional calcium-binding proteins, participates in several physiological and pathological processes. In this study, we demonstrate that S100A4 expression is robustly induced in differentiating fi
Externí odkaz:
https://doaj.org/article/c5d12a9b1ee845928e568c3467712a88
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The avascular eye lens generates its own microcirculation that is required for maintaining lifelong lens transparency. The microcirculation relies on sodium ion flux, an extensive network of gap junction (GJ) plaques between lens fiber cells and tran
Externí odkaz:
https://doaj.org/article/7469d467587141e2b39620984c2e9a19
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176713 (2017)
Our previous work on angiotensin II-mediated electrical-remodeling in canine left ventricle, in connection with a long history of other studies, suggested the hypothesis: increases in mechanical load induce autocrine secretion of angiotensin II (A2),
Externí odkaz:
https://doaj.org/article/e53c587340894b349cc1ec19693a8488
Autor:
Jonathan M. Backer, Adriana Levine, Anne R. Bresnick, Tylor R. Lewis, Vadim Y. Arshavsky, Junyuan Gao, Ponugoti Vasantha Rao, Rupalatha Maddala, Richard T. Mathias
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
S100A4, a member of the S100 family of multifunctional calcium-binding proteins, participates in several physiological and pathological processes. In this study, we demonstrate that S100A4 expression is robustly induced in differentiating fiber cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c086a73753f1a11e5bc54fa5f9d0cb6a
https://doaj.org/article/c5d12a9b1ee845928e568c3467712a88
https://doaj.org/article/c5d12a9b1ee845928e568c3467712a88
Autor:
Richard T. Mathias, Nicholas A. Delamere, Sarah Redmon, Mohammad Shahidullah, Amritlal Mandal, David Križaj, Junyuan Gao
Publikováno v:
Am J Physiol Cell Physiol
The porcine lens response to a hyperosmotic stimulus involves an increase in the activity of an ion cotransporter sodium-potassium/two-chloride cotransporter 1 (NKCC1). Recent studies with agonists and antagonists pointed to a mechanism that appears
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758e0ef77a6df52f41d345f1fc322717
https://doi.org/10.1152/ajpcell.00391.2019
https://doi.org/10.1152/ajpcell.00391.2019
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
The avascular eye lens generates its own microcirculation that is required for maintaining lifelong lens transparency. The microcirculation relies on sodium ion flux, an extensive network of gap junction (GJ) plaques between lens fiber cells and tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed86ff039fb80f120a63d1f8f8cf78a
https://doi.org/10.3389/fphys.2021.772276
https://doi.org/10.3389/fphys.2021.772276
Publikováno v:
Molecular vision. 28
Glutathione peroxidase 1 (GPX1) and catalase are expressed in the lens epithelial cells and cortical fiber cells, where they detoxify H2O2 to reduce oxidative stress, which is a major cause for cataractogenesis. We sought to find out, between these t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e531aefc95908762f96af1a8a88cbd6d
https://pubmed.ncbi.nlm.nih.gov/35400989
https://pubmed.ncbi.nlm.nih.gov/35400989
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138711 (2015)
We recently characterized an autocrine renin angiotensin system (RAS) in canine heart. Activation of Angiotensin II Type 1 Receptors (AT1Rs) induced electrical remodeling, including inhibition of the transient outward potassium current Ito, prolongat
Externí odkaz:
https://doaj.org/article/76bad6a63b994e10b4c68afb186c24c5
Autor:
Viviana M. Berthoud, Richard T. Mathias, Peter J. Minogue, Oscar Jara, Junyuan Gao, Eric C. Beyer
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5822, p 5822 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 5822, p 5822 (2020)
Gap junction-mediated intercellular communication facilitates the circulation of ions, small molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap junction proteins, connexin46 (Cx46) and connexin50 (Cx50), cause ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a148c5990f8d70ce1aa1b66d73ea9b4c
https://pubmed.ncbi.nlm.nih.gov/32823750
https://pubmed.ncbi.nlm.nih.gov/32823750