Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Richard T, Clements"'
ML-GAP: machine learning-enhanced genomic analysis pipeline using autoencoders and data augmentation
Autor:
Melih Agraz, Dincer Goksuluk, Peng Zhang, Bum-Rak Choi, Richard T. Clements, Gaurav Choudhary, George Em Karniadakis
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionThe advent of RNA sequencing (RNA-Seq) has significantly advanced our understanding of the transcriptomic landscape, revealing intricate gene expression patterns across biological states and conditions. However, the complexity and volume
Externí odkaz:
https://doaj.org/article/47840e320b1f4afaaecb8f10ac3db67a
Autor:
Peng Zhang, Denielli Da Silva Goncalves Bos, Alexander Vang, Julia Feord, Danielle J. McCullough, Alexsandra Zimmer, Natalie D'Silva, Richard T. Clements, Gaurav Choudhary
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 2, Pp n/a-n/a (2024)
Abstract Reduced exercise capacity in pulmonary hypertension (PH) significantly impacts quality of life. However, the cause of reduced exercise capacity in PH remains unclear. The objective of this study was to investigate whether intrinsic skeletal
Externí odkaz:
https://doaj.org/article/121e8e70e2a144189447e92323cadc38
Autor:
Alexander Vang, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R. Morrison, Thomas J. Mancini, Richard T. Clements, Iuliia Polina, Michael W. Cypress, Bong Sook Jhun, Edward Hawrot, Ulrike Mende, Jin O-Uchi, Gaurav Choudhary
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Right ventricular (RV) fibrosis is a key feature of maladaptive RV hypertrophy and dysfunction and is associated with poor outcomes in pulmonary hypertension (PH). However, mechanisms and therapeutic strategies to mitigate RV fibrosis remain unrealiz
Externí odkaz:
https://doaj.org/article/c09c89c74fdf402a92c4c34005193f3d
Autor:
Danielle J. McCullough, Nouaying Kue, Thomas Mancini, Alexander Vang, Richard T. Clements, Gaurav Choudhary
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Pulmonary hypertension is associated with pronounced exercise intolerance (decreased V ċ O 2 max) that can significantly impact quality of life. The cause of exercise intolerance in pulmonary hypertension remains unclear. Mitochondrial supercomplexe
Externí odkaz:
https://doaj.org/article/cba774dd40ca4136a9cc616ff71451f7
Autor:
Richard T. Clements, Radmila Terentyeva, Shanna Hamilton, Paul M. L. Janssen, Karim Roder, Benjamin Y. Martin, Fruzsina Perger, Timothy Schneider, Zuzana Nichtova, Anindhya S. Das, Roland Veress, Beth S. Lee, Do-Gyoon Kim, Gideon Koren, Matthew S. Stratton, Gyorgy Csordas, Federica Accornero, Andriy E. Belevych, Sandor Gyorke, Dmitry Terentyev
Publikováno v:
Basic Research in Cardiology. 118
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca2+ release is essential to boost energy production in ventricular cardiomyocytes (VCMs) and match increased metabolic demand. Mitochondria from female hearts exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc16c7193cf2b8cedadcf67efa7dafc
https://doi.org/10.1007/s00395-023-00988-1
https://doi.org/10.1007/s00395-023-00988-1
Autor:
Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T. Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca2+ uptake, an important regulator of cellular ATP homeostas
Externí odkaz:
https://doaj.org/article/afd9fd2a470d40ac8bbdb50a6b5dfb09
Autor:
Benjamin Martin, Matthew W. Gorr, Richard T. Clements, Fruzsina Perger, Sandor Gyorke, Benjamin Hernandez Orengo, Dmitry Terentyev, Andriy E. Belevych, Radmila Terentyeva, Shanna Hamilton
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H615-H632
Defective intracellular Ca2+ homeostasis and aberrant mitochondrial function are common features in cardiac disease. Here, we directly compared potential benefits of mito-ROS scavenging and restoration of mito-Ca2+ uptake by overexpressing MCU in ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb9530054661e309d66567bb924a2cb
https://doi.org/10.1152/ajpheart.00126.2021
https://doi.org/10.1152/ajpheart.00126.2021
Autor:
Richard T. Clements, Shanna Hamilton, Dmitry Terentyev, Andriy E. Belevych, Radmila Terentyeva
Publikováno v:
J Mol Cell Cardiol
Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88bc40c855ee063c21fe5ce2214f4d1
https://doi.org/10.1016/j.yjmcc.2021.04.002
https://doi.org/10.1016/j.yjmcc.2021.04.002
Autor:
Brittany A. Potz, Ashraf A. Sabe, Nassrene Y. Elmadhun, Richard T. Clements, Michael P. Robich, Neel R. Sodha, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 7 (2016)
BackgroundInhibition of glycogen synthase kinase 3β (GSK‐3β) has been reported to be cardioprotective during stressful conditions. Methods and ResultsPigs were fed a high‐fat diet for 4 weeks to develop metabolic syndrome, then underwent placem
Externí odkaz:
https://doaj.org/article/21b9c6b2254e46218b741469886e574a
Autor:
Wenzhuo Ma, Neel Sodha, Martin Kolodziejczak, Zhiqi Zhang, Afshin Ehsan, Scarlett Huck, Clarissa Cavarsan, Frank Sellke, Jun Feng, Dmitry A. Terentyev, Richard T. Clements
Publikováno v:
Biophysical Journal. 122:97a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42c048284954d6cfd0b4c299fcd76204
https://doi.org/10.1016/j.bpj.2022.11.717
https://doi.org/10.1016/j.bpj.2022.11.717