Výsledky vyhledávání - "Richard Steinbrugger"

Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells

Autor: Thomas Höchtl, Walter Jäger, Monika Fritzer-Szekeres, Howard L. Elford, Georg Krupitza, Michael Grusch, Richard Steinbrugger, Alexandra Salamon, Zsuzsanna Horvath, Thomas Szekeres

Publikováno v: Biochemical Pharmacology. 64:481-485

Ribonucleotide reductase is the rate-limiting enzyme for the de novo synthesis of deoxynucleoside triphosphates and therefore represents a good target for cancer chemotherapy. Trimidox (3,4,5-trihydroxybenzamidoxime) was identified as a potent inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4ab7a40f3d9954fd17bffa9784fbbb
https://doi.org/10.1016/s0006-2952(02)01186-3

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Cyclosporine Metabolism in Patients After Kidney, Bone Marrow, Heart-Lung, and Liver Transplantation in the Early and Late Posttransplant Periods

Autor: Richard Steinbrugger, Alexandra Salomon, Walter Jäger, Monika Fritzer-Szekeres, Ahmad Hamwi, Thomas Szekeres

Publikováno v: American Journal of Clinical Pathology. 114:536-543

Cyclosporine is used in the prevention of allograft rejection. Owing to its narrow therapeutic index, regular monitoring of the whole blood levels of cyclosporine is required. We observed that immunoassays measured significantly higher cyclosporine l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc20ee10685a57e2ca670739ba8c02ba
https://doi.org/10.1309/8pgn-0c9e-3nb9-cjk5

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TNFα-mediated cell death is independent of Cdc25A

Autor: Gerhard Fuhrmann, Katja Braun, Wolfgang Hulla, Andreas Chott, Markus Hengstschläger, Richard Steinbrugger, Michael Grusch, Ingrid Simonitsch, George Krupitza

Publikováno v: Cell Death & Differentiation. 5:758-764

Tumor necrosis factor (TNFs) have been shown to be synthesized by ovarian carcinomas, and may therefore affect tumor cells in an autocrine manner. Therefore, we investigated the effects of recombinant TNFs on ovarian carcinoma cells N.1 and examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0776da6539fb538d067a4d1427e4482
https://doi.org/10.1038/sj.cdd.4400417

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