Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Richard Starkey"'
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
In vitro kinase assays demonstrate selectivity of ICEC0942 for CDK7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3115379f20023b58b11b5bd3f114b3e9
https://doi.org/10.1158/1535-7163.22505256.v1
https://doi.org/10.1158/1535-7163.22505256.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Cell Cycle analysis of MCF7 cells treated with ICEC0942.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073ce1054b7e5efb820e8752e3605f1b
https://doi.org/10.1158/1535-7163.22505250
https://doi.org/10.1158/1535-7163.22505250
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Pharmacokinetic determination of ICEC0942 plasma and tumor concentrations at different doses and over time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17467448f27fd6b449403fa209df6230
https://doi.org/10.1158/1535-7163.22505241
https://doi.org/10.1158/1535-7163.22505241
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7954b2e0f9b8731f18d462f3b2edad27
https://doi.org/10.1158/1535-7163.c.6537999.v1
https://doi.org/10.1158/1535-7163.c.6537999.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Combinatorial inhibition of breast cancer cells with a combination of ICEC0942 and anti-estrogens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5321be6de1307f6ffb170d40537515be
https://doi.org/10.1158/1535-7163.22505238.v1
https://doi.org/10.1158/1535-7163.22505238.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Analysis of ICEC0942 treatment of MCF7 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8b1b0e7c302e2aefdf9fb927995938
https://doi.org/10.1158/1535-7163.22505253.v1
https://doi.org/10.1158/1535-7163.22505253.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Oral administration of ICEC0942 inhibits cyclin-dependent kinase substrate phosphorylation in mouse peripheral blood mononuclear cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7524b4479fdbe0b77676066b29c3d69d
https://doi.org/10.1158/1535-7163.22505244.v1
https://doi.org/10.1158/1535-7163.22505244.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Figure legends for supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e68a2e65994bf8e6171e2a36349138
https://doi.org/10.1158/1535-7163.22505235
https://doi.org/10.1158/1535-7163.22505235
Autor:
Alexander Bondke, Georgina P. Sava, Silvia Ottaviani, Agm Barrett, Richard Starkey, Lakjaya Buluwela, Eric O. Aboagye, R. C. Coombes, Sajid Ali, Matthew J. Fuchter, Marion Barbazanges, Hetal Patel, Alison Harrod, B. W. Slafer, Manikandan Periyasamy, Shb Kroll
Publikováno v:
Cancer Research. 78:P1-10
CDK7 is remarkable as a key regulator of both cell cycle progression and gene expression. CDK7 promotes cell cycle progression by phosphorylating cell cycle CDKs in the T-loop, thus stimulating their activities. Additionally, phosphorylation of RNA p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec51ec335fc1aa4db122cc698d9d2f05
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-05
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-05
Autor:
Georgina P. Sava, Simak Ali, Richard Starkey, Alexander Bondke, Manikandan Periyasamy, Alison Harrod, Laki Buluwela, Marion Barbazanges, Eric O. Aboagye, Hetal Patel, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, B. W. Slafer, Silvia Ottaviani, Sebastian H. B. Kroll
Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685548f616aca29c3ee612b4147858e2
http://hdl.handle.net/10044/1/64250
http://hdl.handle.net/10044/1/64250