Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

Autor: Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, Nasrin Sarafan-Vasseur, Richard Sesboüé, Pierre-Yves Renard, Luc Thiberville, Mathieu Salaün

Publikováno v: BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)

Abstract Background EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of mutated EGFR tumou

Externí odkaz: https://doaj.org/article/c2992972b3fb4d9a8bfe21bb646f20da

Supplementary Table 1 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Autor: Jean-Baptiste Latouche, Jérôme Galon, Thierry Frébourg, Pierre Michel, Jean-Christophe Sabourin, Jean-Jacques Tuech, Richard Sesboüé, Florence Le Pessot, Jacques Mauillon, Jacques Benichou, Jérôme Leprince, Aurélie Drouet, Emilie Fauquembergue, Nicolas Elie, Tessa Fredriksen, Helen K. Angell, Gabriela Bindea, Hafid Kora, Bernhard Mlecnik, Mohamad Hamieh, David Tougeron, Pauline Maby

Frequency of frameshift mutations within target genes and proportion of tumors harboring these mutations in all malignant cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06823b9f31a28f29bbcdc4e76d6520e5
https://doi.org/10.1158/0008-5472.22406570.v1

Supplementary Figure Legend from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Autor: Jean-Baptiste Latouche, Jérôme Galon, Thierry Frébourg, Pierre Michel, Jean-Christophe Sabourin, Jean-Jacques Tuech, Richard Sesboüé, Florence Le Pessot, Jacques Mauillon, Jacques Benichou, Jérôme Leprince, Aurélie Drouet, Emilie Fauquembergue, Nicolas Elie, Tessa Fredriksen, Helen K. Angell, Gabriela Bindea, Hafid Kora, Bernhard Mlecnik, Mohamad Hamieh, David Tougeron, Pauline Maby

Supplementary Figure Legend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618a015739d82f212cd3e9f1bd029adc
https://doi.org/10.1158/0008-5472.22406576.v1

Supplementary Figure 3 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Autor: Jean-Baptiste Latouche, Jérôme Galon, Thierry Frébourg, Pierre Michel, Jean-Christophe Sabourin, Jean-Jacques Tuech, Richard Sesboüé, Florence Le Pessot, Jacques Mauillon, Jacques Benichou, Jérôme Leprince, Aurélie Drouet, Emilie Fauquembergue, Nicolas Elie, Tessa Fredriksen, Helen K. Angell, Gabriela Bindea, Hafid Kora, Bernhard Mlecnik, Mohamad Hamieh, David Tougeron, Pauline Maby

Supplementary Figure 3. In vitro cytotoxic activity of peripheral TLs from donors harboring or not mutations in TGFBR2, TAF1B and ASTE1 genes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6c2d83d32ac6066e858ca5c8bc6115
https://doi.org/10.1158/0008-5472.22406579

Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

Autor: Anthony Romieu, Pierre-Yves Renard, Maxime Patout, Nasrin Sarafan-Vasseur, Mathieu Salaün, Xavier Brune, Pierre Bohn, Richard Sesboüé, Florian Guisier, Luc Thiberville

Publikováno v: BMC Pulmonary Medicine
BMC Pulmonary Medicine, BioMed Central, 2019, 19, pp.3. ⟨10.1186/s12890-018-0760-z⟩
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)

Background EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of mutated EGFR tumours in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c255f6c235b3b10a00d78e8ef8735d
https://doi.org/10.1186/s12890-018-0760-z