Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Richard Sachse"'
Autor:
Ulrich Moebius, Radek Špíšek, David Béchard, Nada Podzimkova, Irena Adkins, Richard Sachse, Joachim Kiemle-Kallee, Ekaterina Simonova, Lenka Palova Jelinkova, Petr Danek, Martin Steegmaier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/92cbfc6838ee446fb5af12ab8560567e
Autor:
Stephane Champiat, Aurélien Marabelle, Aung Naing, Filip Janku, Patricia LoRusso, David Béchard, Elena Garralda, Vladimir Galvao, Peter Grell, Richard Sachse, Joachim Kiemle-Kallee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/007335cb94fa431999a325bb10f4dbd9
Autor:
Stephane Champiat, Aurelien Marabelle, Diwakar Davar, Peter Grell, Kaissa Ouali, Anna Patrikidou, Andreu Schoenenberger, Lenka Palova Jelinkova, Irena Adkins, Sascha Tillmanns, Joachim Kiemle-Kallee, Richard Sachse, Elena Garralda
Publikováno v:
Regular and Young Investigator Award Abstracts.
Publikováno v:
Clinical Pharmacology in Drug Development
Macimorelin is an orally active growth hormone secretagogue indicated for the diagnosis of adult growth hormone deficiency. The primary objective of this study was to evaluate the effect of macimorelin on the baseline and placebo‐corrected mean QT
Autor:
Stephane Champiat, Aurelien Marabelle, Vladimir Galvao, Patricia LoRusso, Peter Grell, Philippe Cassier, Carlos Gomez-Roca, Iphigenie Korakis, Aung Naing, Lenka Palova Jelinkova, Irena Adkins, Ulrich Moebius, Richard Sachse, Sascha Tillmanns, David Bechard, Joachim Kiemle-Kallee, Elena Garralda
Publikováno v:
Cancer Research. 82:CT040-CT040
Introduction: SOT101 (previously SO-C101), a fusion protein of IL-15 and the IL-15 receptor α sushi+ domain, was investigated in an open-label, multicenter, dose-escalation study as monotherapy and in combination with pembrolizumab in patients with
Autor:
Filip Janku, Stéphane Champiat, Alberto Hernando, Richard Sachse, Stefano Ferrara, Elena Garralda, Anjali Raina, Patricia LoRusso, Inna Krasnopolskaya, David Bechard, Aurélien Marabelle
Publikováno v:
Late-breaking abstracts.
Background IL-15 is a member of the common y-chain family of cytokines that shares functional activities with IL-2. SO-C101is a superagonist fusion protein of IL-15 and the IL-15 receptor α sushi+ domain. SO-C101 stimulates the proliferation and the
Autor:
Joachim Kiemle-Kallee, Aurélien Marabelle, Aung Naing, Richard Sachse, Peter Grell, Filip Janku, Vladimir Galvao, David Bechard, Stéphane Champiat, Ellena Garralda, Patricia LoRusso
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A534-A534
BackgroundSO-C101 is a superagonist fusion protein of IL-15 and the IL-15 receptor α sushi+ domain. SO-C101 was investigated in a multicenter, open-label, dose escalation study as monotherapy and in combination with pembrolizumab in patients with se
Autor:
Elena Garralda, Vladimir Galvao, Stephane Champiat, Patricia LoRusso, Peter Grell, Aung Naing, Filip Janku, Richard Sachse, David Bechard, Joachim Kiemle-Kallee, Aurelien Marabelle
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundSO-C101 (IL 15/IL-15Rα sushi + domain fusion protein) was investigated in a multicenter, open-label, dose escalation study as monotherapy and in combination with pembrolizumab in patients with selected advanced/metastatic tumors (NCT042341
Autor:
Sandra Pekic, Thomas Blevins, Márta Korbonits, Vera Popovic, Marek Bolanowski, Beverly M. K. Biller, Ronald S. Swerdloff, Richard Sachse, Anton Luger, Nicola Ammer, Milica Medic-Stojanoska, Anna Zakrzewska, Christina Wang, Marco Marcelli, Jose M. Garcia, Philippe Chanson, Jochen Schopohl, Christian J. Strasburger, Kevin C.J. Yuen
Publikováno v:
Journal of the Endocrine Society
"Best of" The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 8, 1 August 2018, Pages 3083-3093, https://doi.org/10.1210/jc.2018-00665. Purpose: The diagnosis of adult GH deficiency (AGHD) is challenging and often requires confirmat
Publikováno v:
Growth Hormone & IGF Research. 52:101321
Objective Macimorelin is an orally active ghrelin receptor agonist indicated for the diagnosis of adult growth hormone (GH) deficiency in the United States. This phase 1 study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics