Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Richard S. P. Hsi"'
Autor:
Wayne T. Stolle, Richard S. P. Hsi, Susanne R. Haadsma-Svensson, Chiu-Hong Lin, Mark J. Ackland, John A. Easter
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 39:891-900
The title compound is a potent and selective 5-HT 1A receptor agonist with clinical potentials for treating anxiety and depression. It has been labeled with stable and radioactive isotopes to support ADME studies in animals and human subjects. Its ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c4b82a6b4c5a1305e11b7c8a53f8bc
https://doi.org/10.1002/(sici)1099-1344(199711)39:11<891::aid-jlcr34>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199711)39:11<891::aid-jlcr34>3.0.co
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 38:1087-1098
(R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (1) is a dopamine agonist which shows selectivity for the D2 receptor subtype, and is of interest as a potential drug for the treatment of Parkinson's disease. An asymmetric epoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7180b10ba6543054a525b349cd2c8000
https://doi.org/10.1002/(sici)1099-1344(199612)38:12<1087::aid-jlcr933>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199612)38:12<1087::aid-jlcr933>3.0.co
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:1175-1186
In the search for a radioactive form of the peptidomimetic renin inhibitor, ditekiren, with a metabolically suitable radiolabel for conducting drug disposition studies, we prepared [3H]ditekiren with tritium labels in the N-methyl-histidine moiety an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d6612833d694c6773639eae82bbcb1f
https://doi.org/10.1002/jlcr.2580341207
https://doi.org/10.1002/jlcr.2580341207
Autor:
Wayne T. Stolle, John R. Palmer, Richard S. P. Hsi, E. H. Chew, J. A. Easter, James P. McGrath
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:1187-1199
Tirilazad mesylate, 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione monomethanesulfonate, is a potent lipid peroxidation inhibitor capable of suppressing progression of tissue damage caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5145040c6e0d4f2b846738a975324b29
https://doi.org/10.1002/jlcr.2580341208
https://doi.org/10.1002/jlcr.2580341208
Autor:
Salvatore Charles Perricone, Jackson B. Hester, Wayne T. Stolle, Richard S. P. Hsi, Lindsay S. Stelzer
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:929-942
Ibutilide fumarate, racemic N-[4-[4-(ethyl-n-heptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate, and artilide, the R-(+)-enantiomer of N-[4-[4-(di-n-butylalmino)-1-hydroxybutyl]-phenyl]methanesulfonamide hemifumerate, are under clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c9f50d96873126253188e926b7c224
https://doi.org/10.1002/jlcr.2580341006
https://doi.org/10.1002/jlcr.2580341006
Autor:
Gordon L. Bundy, J. A. Easter, Y. Philopoulos, Richard S. P. Hsi, A. J. Wickrema Sinha, L. S. Banitt
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:827-838
This report describes an efficient stereoselective synthesis of [11β-3H]prostaglandin E1 ([11β-3H]PGE1). The key multiply protected 11-keto intermediate was prepared in only three steps from PGE1. Reduction of the ketone function at C-11 with sodiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5778b2c965a5e4901a4ca03908af1505
https://doi.org/10.1002/jlcr.2580330906
https://doi.org/10.1002/jlcr.2580330906
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 28:555-580
Methylprednisolone suleptanate was initially labeled with tritium in the A-ring of the steroid portion of the molecule, and with carbon-14 at both carboxylic carbons of the suberic acid portion of the side chain. However these labels proved to lack t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c96cc9c744b87e87a897ae887d144ee
https://doi.org/10.1002/jlcr.2580280507
https://doi.org/10.1002/jlcr.2580280507
Autor:
Wayne T. Stolle, Richard S. P. Hsi
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 38:1147-1149
Palladium-on-charcoal catalyzed reduction of N-methyl-3-(3-bromo)phenyl-3-(4-trifluoromethyl)phenoxypropylamine (1) with tritium gas produces a mixture of the debrominated product [ 3 H]fluoxetine (2) and N-methyl-3-[3- 3 H]phenylpropylamine(3), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf514fe6ab23968cf5456187236af95
https://doi.org/10.1002/(sici)1099-1344(199612)38:12<1147::aid-jlcr926>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199612)38:12<1147::aid-jlcr926>3.0.co
Publikováno v:
Isotope Production and Applications in the 21st Century.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cae30638e4efe6567d2176c687f545ec
https://doi.org/10.1142/9789812793867_0083
https://doi.org/10.1142/9789812793867_0083
Autor:
Robert A. Lahti, Malcolm W. Moon, D.L. Evans, K.J. Carrigan, Lana M. Figur, Richard S. P. Hsi
Publikováno v:
European Journal of Pharmacology. 202:289-291
U-86170F, an imidazoguinolinone, is a potent dopamine D2 agonist, binding with high affinity to the dopamine D2 receptor. A Kd of 0.99 nM was determined in membranes from Chinese hamster ovarian (CHO) cells transfected with the D2 receptor and a Kd o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a265a8dc7106b79c72822c3d9ccaace3
https://doi.org/10.1016/0014-2999(91)90308-d
https://doi.org/10.1016/0014-2999(91)90308-d