Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Richard S. Mann"'
Autor:
Siqian Feng, Chaitanya Rastogi, Ryan Loker, William J. Glassford, H. Tomas Rube, Harmen J. Bussemaker, Richard S. Mann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Feng et al. compare the genome-wide binding and activity of two Drosophila Hox transcription factors that determine the identities of different fly legs. For binding events that are Hox specific, two cofactors, Exd and Dll, are used to achieve specif
Externí odkaz:
https://doaj.org/article/1d593ab08c24437783d53d88f829132d
Autor:
Carlos Sánchez-Higueras, Chaitanya Rastogi, Roumen Voutev, Harmen J. Bussemaker, Richard S. Mann, James C.-G. Hombría
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Hox proteins are expressed in partially overlapping regions to inform development along the embryo’s head-tail axis. Here the authors analyse a cis regulatory module directly regulated by seven different Drosophila Hox proteins to uncover how diffe
Externí odkaz:
https://doaj.org/article/33fa56c7633f40faac90d12b3fc513f9
Autor:
Roumen Voutev, Richard S. Mann
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 4, Pp 983-986 (2019)
Molecular biology techniques have a large impact on biomedical research and the availability of diverse tools to perform genome manipulations advances the ease of executing complicated genetic research. Here, we introduce in the fruit fly another suc
Externí odkaz:
https://doaj.org/article/317404a6d93945a999d780a8c314c413
Autor:
Roumen Voutev, Richard S. Mann
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1399-1402 (2018)
Effective genome engineering should lead to a desired locus change with minimal adverse impact to the genome itself. However, flanking loci with site-directed recombinase recognition sites, such as those of the phage ΦC31 integrase, allows for creat
Externí odkaz:
https://doaj.org/article/9c947d5b97d74a8fa9582c85dd75ef2f
Autor:
Satyanarayan Rao, Tsu-Pei Chiu, Judith F. Kribelbauer, Richard S. Mann, Harmen J. Bussemaker, Remo Rohs
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-11 (2018)
Abstract Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited. Cytosine methylation, the most f
Externí odkaz:
https://doaj.org/article/fd1540a0a7e54197bf016c4da6e51072
Autor:
Judith F. Kribelbauer, Oleg Laptenko, Siying Chen, Gabriella D. Martini, William A. Freed-Pastor, Carol Prives, Richard S. Mann, Harmen J. Bussemaker
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2383-2395 (2017)
Although DNA modifications play an important role in gene regulation, the underlying mechanisms remain elusive. We developed EpiSELEX-seq to probe the sensitivity of transcription factor binding to DNA modification in vitro using massively parallel s
Externí odkaz:
https://doaj.org/article/96450b41b63b4adabe6fbb346d6d73d5
Autor:
Roumen Voutev, Richard S. Mann
Publikováno v:
BioTechniques, Vol 60, Iss 3, Pp 141-144 (2016)
Enhancer elements in most eukaryotic organisms are often positioned at a great distance away from the transcription start site of the gene they regulate. Complex three-dimensional chromatin organization and insulators usually guide and limit the rang
Externí odkaz:
https://doaj.org/article/7af276018953464db564dbd595b319da
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 449-459 (2014)
Hippo signaling limits organ growth by inhibiting the transcriptional coactivator Yorkie. Despite the key role of Yorkie in both normal and oncogenic growth, the mechanism by which it activates transcription has not been defined. We report that Yorki
Externí odkaz:
https://doaj.org/article/6237019be43c4be3bafe27e884cddafc
Autor:
Hyangyee Oh, Matthew Slattery, Lijia Ma, Alex Crofts, Kevin P. White, Richard S. Mann, Kenneth D. Irvine
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 309-318 (2013)
The Hippo pathway regulates growth through the transcriptional coactivator Yorkie, but how Yorkie promotes transcription remains poorly understood. We address this by characterizing Yorkie’s association with chromatin and by identifying nuclear par
Externí odkaz:
https://doaj.org/article/1dc37da7a1e64398a80ebbce5044188f
Autor:
Aurélie Jory, Carlos Estella, Matt W. Giorgianni, Matthew Slattery, Todd R. Laverty, Gerald M. Rubin, Richard S. Mann
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 1014-1024 (2012)
Over 6,000 fragments from the genome of Drosophila melanogaster were analyzed for their ability to drive expression of GAL4 reporter genes in the third-instar larval imaginal discs. About 1,200 reporter genes drove expression in the eye, antenna, leg
Externí odkaz:
https://doaj.org/article/46028d1c34894dbabc670369655d6250