Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Richard S. Bujaroski"'
Autor:
Kiel Hards, Chen-Yi Cheung, Natalie Waller, Cara Adolph, Laura Keighley, Zhi Shean Tee, Liam K. Harold, Ayana Menorca, Richard S. Bujaroski, Benjamin J. Buckley, Joel D. A. Tyndall, Matthew B. McNeil, Kyu Y. Rhee, Helen K. Opel-Reading, Kurt Krause, Laura Preiss, Julian D. Langer, Thomas Meier, Erik J. Hasenoehrl, Michael Berney, Michael J. Kelso, Gregory M. Cook
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Derivatives of the FDA-approved drug, amiloride, can eliminate drug-resistant Mycobacterium tuberculosis in vitro by interfering with bacterial energy conservation.
Externí odkaz:
https://doaj.org/article/dae3bf53428948ca8c7fbb2eb80c8d45
Autor:
Kiem Vu, Benjamin J. Buckley, Richard S. Bujaroski, Eduardo Blumwald, Michael J. Kelso, Angie Gelli
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to multi-drug resistance. This reality underscores the need to develop novel drugs with uniqu
Externí odkaz:
https://doaj.org/article/9f2a367dfa99493b98e4fd848a7e2a1a
Autor:
Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1309 (2022)
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules. Human P2X7 can be partially inhib
Externí odkaz:
https://doaj.org/article/ec5409f7111249ca998740badc225245
Autor:
Benjamin J. Buckley, Ashna Kumar, Ashraf Aboelela, Richard S. Bujaroski, Xiuju Li, Hiwa Majed, Larry Fliegel, Marie Ranson, Michael J. Kelso
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2999 (2021)
The K+-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a c
Externí odkaz:
https://doaj.org/article/6ad7a2f6d6794c90827ed3eb4b6fcc6e
Autor:
Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Ashraf Aboelela, Richard S. Bujaroski, Hiwa Majed, Alejandra Rangel, David J. Adams, Marie Ranson, Michael J. Kelso, Benjamin J. Buckley
Acid-sensing ion channels (ASICs) are transmembrane sensors of extracellular acidosis and potential drug targets in several disease indications, including neuropathic pain and cancer metastasis. The K+-sparing diuretic amiloride is a moderate non-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba14ffe5766c44ccd30f35396253dd5
https://doi.org/10.1101/2022.03.12.484055
https://doi.org/10.1101/2022.03.12.484055
Autor:
Kiel, Hards, Chen-Yi, Cheung, Natalie, Waller, Cara, Adolph, Laura, Keighley, Zhi Shean, Tee, Liam K, Harold, Ayana, Menorca, Richard S, Bujaroski, Benjamin J, Buckley, Joel D A, Tyndall, Matthew B, McNeil, Kyu Y, Rhee, Helen K, Opel-Reading, Kurt, Krause, Laura, Preiss, Julian D, Langer, Thomas, Meier, Erik J, Hasenoehrl, Michael, Berney, Michael J, Kelso, Gregory M, Cook
Publikováno v:
Communications biology. 5(1)
Increasing antimicrobial resistance compels the search for next-generation inhibitors with differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium tuberculosis has been clinically validated as a promising new dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27d4818343c40ab81f2a54807685303c
https://pubmed.ncbi.nlm.nih.gov/35210534
https://pubmed.ncbi.nlm.nih.gov/35210534
Autor:
Karen L. White, Gregory M. Cook, Richard S. Bujaroski, David M. Shackleford, Hiwa Majed, Ashraf Aboelela, Marie Ranson, Andrew K. Powell, Kasiram Katneni, Jessica Saunders, Benjamin J. Buckley, Wen Wang, Michael J. Kelso, Susan A. Charman
Publikováno v:
Bioorganic & Medicinal Chemistry. 37:116116
The K+-sparing diuretic amiloride elicits anticancer activities in multiple animal models. During our recent medicinal chemistry campaign aiming to identify amiloride analogs with improved properties for potential use in cancer, we discovered novel 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb389c2cdef3a34dd281000acacdf9f7
https://doi.org/10.1016/j.bmc.2021.116116
https://doi.org/10.1016/j.bmc.2021.116116
Autor:
Richard S. Bujaroski, Ashraf Aboelela, Michael J. Kelso, Marie Ranson, Xiuju Li, Benjamin J. Buckley, Larry Fliegel, Hiwa Majed, Ashna Kumar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2999, p 2999 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences
Volume 22
Issue 6
The K+-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455997027e800d323a4f6396625a4fdb
https://doi.org/10.3390/ijms22062999
https://doi.org/10.3390/ijms22062999