Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Richard S Roberts"'
Autor:
Ann Sluder, Sheetal Shah, Jérôme Cassayre, Ralph Clover, Peter Maienfisch, Louis-Pierre Molleyres, Elizabeth A Hirst, Anthony J Flemming, Min Shi, Penny Cutler, Carole Stanger, Richard S Roberts, David J Hughes, Thomas Flury, Michael P Robinson, Elke Hillesheim, Thomas Pitterna, Fredrik Cederbaum, Paul A Worthington, Andrew J Crossthwaite, John D Windass, Richard A Currie, Fergus G P Earley
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e34712 (2012)
The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at nove
Externí odkaz:
https://doaj.org/article/01ae6528af6c47e98391b659caff9a2a
Autor:
Javier, García-Cárceles, Henar, Vázquez-Villa, José, Brea, David, Ladron de Guevara-Miranda, Giovanni, Cincilla, Melchor, Sánchez-Martínez, Anabel, Sánchez-Merino, Sergio, Algar, María, Teresa de Los Frailes, Richard S, Roberts, Juan A, Ballesteros, Fernando, Rodríguez de Fonseca, Bellinda, Benhamú, María I, Loza, María L, López-Rodríguez
Publikováno v:
Journal of medicinal chemistry. 65(18)
Tolerance development caused by dopamine replacement with l-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson's disease. In
Autor:
Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de los Frailes, Richard S. Roberts, Juan A. Ballesteros, Fernando Rodríguez de Fonseca, Bellinda Benhamú, María I. Loza, María L. López-Rodríguez
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
instname
instname
Tolerance development caused by dopamine replacement with L-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson’s disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ee8cb90d20910f36acb8e932c24b4d
https://hdl.handle.net/10668/22592
https://hdl.handle.net/10668/22592
Publikováno v:
The SHAFR Guide Online
Externí odkaz:
https://doi.org/10.1163/2468-1733_shafr_SIM030060253
Autor:
Richard S. Roberts
Publikováno v:
Appropriate Technology for Development ISBN: 9780429051418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f4d2c32c39057c841fa88538e51eb98
https://doi.org/10.4324/9780429051418-14
https://doi.org/10.4324/9780429051418-14
Autor:
Richard S. Roberts
Publikováno v:
Appropriate Technology for Development ISBN: 9780429051418
Appropriate Technology for Development
Appropriate Technology for Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0b4118efa94f05abe4d88a69166f1c1
https://doi.org/10.4324/9780429051418-2
https://doi.org/10.4324/9780429051418-2
Autor:
Manel Ferrer, Elena Calama, Richard S. Roberts, Begoña Hernández, Sara Sevilla, Judit Cabedo, Dolors Vilella, Peter Eichhorn, Amadeu Gavaldà, Miriam Andrés, Jordi Gràcia, Martin D. Lehner, Carla Carcasona, Joan Taltavull, Victor Segarra, Montserrat Miralpeix
Publikováno v:
Journal of medicinal chemistry. 61(6)
Rational design of a novel template of naphthyridinones rapidly led to PDE4 inhibitors with subnanomolar enzymatic potencies. X-ray crystallography confirmed the binding mode of this novel template. We achieved compounds with double-digit picomolar e
Autor:
Laura Vidal, Miriam Andrés, Marta Mir, Pilar Forns, Sara Sevilla, Bernat Vidal, Estrella Lozoya, Cristina Esteve, Mónica Bravo, Manel Ferrer, Paul R. Eastwood, Richard S. Roberts, Jordi Castro, Elena Gómez, Marta Calbet, Pere Vilaseca, Jacob González, Imma Moreno, Silvia Petit, J. A. Alonso, Maria Antonia Buil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5127-5133
The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for long receptor residence time. The HBA in combination with a small steric substituent in the
Autor:
Cristina Esteve, Jacob González, Pere Vilaseca, Marta Calbet, Imma Moreno, Marta Mir, Richard S. Roberts, Silvia Petit, Elena Gómez, Mónica Bravo, Miriam Zanuy, J. A. Alonso, Manel Ferrer, Sara Sevilla, Laura Vidal, Peter Eichhorn, Miriam Andrés, Paul R. Eastwood, Bernat Vidal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5123-5126
Extensive structure–activity relationship (SAR) and structure–kinetic relationship (SKR) studies in the bicyclic heteroaromatic series of CRTh2 antagonists led to the identification of several molecules that possessed both excellent binding and c
Autor:
Richard S. Roberts, Maria Antonia Buil, Peter Eichhorn, Paul R. Eastwood, Imma Moreno, Silvia Petit, Pilar Forns, Jordi Castro, Oscar Casado, Manel Ferrer, Miriam Andrés, Marta Calbet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5111-5117
Pyrrolopiperidinone acetic acids (PPAs) were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed slow-dissociation kinetics from the receptor. Structure–kinetic relationship (SKR) studies allowed o