Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Richard S Paules"'
Autor:
Deepak Mav, Dhiral P Phadke, Michele R Balik-Meisner, B Alex Merrick, Scott Auerbach, Marije Niemeijer, Suzanna Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, Bob van de Water, Ruchir R Shah, Richard S Paules
Publikováno v:
Bioinformatics and Biology Insights, Vol 14 (2020)
The TempO-Seq S1500+ platform(s), now available for human, mouse, rat, and zebrafish, measures a discrete number of genes that are representative of biological and pathway co-regulation across the entire genome in a given species. While measurement o
Externí odkaz:
https://doaj.org/article/d6f389cb95e54e188488ba1e4c1a51c4
Autor:
Deepak Mav, Ruchir R Shah, Brian E Howard, Scott S Auerbach, Pierre R Bushel, Jennifer B Collins, David L Gerhold, Richard S Judson, Agnes L Karmaus, Elizabeth A Maull, Donna L Mendrick, B Alex Merrick, Nisha S Sipes, Daniel Svoboda, Richard S Paules
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191105 (2018)
Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses induced by exposures to chemicals, drugs and environment agents. The U.S. Tox21 Federal col
Externí odkaz:
https://doaj.org/article/ac4c3100313c431db2f048cc682fb4c1
Autor:
Abigail J Morales, Javier A Carrero, Putzer J Hung, Anthony T Tubbs, Jared M Andrews, Brian T Edelson, Boris Calderon, Cynthia L Innes, Richard S Paules, Jacqueline E Payton, Barry P Sleckman
Publikováno v:
eLife, Vol 6 (2017)
Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded
Externí odkaz:
https://doaj.org/article/8b32ac03f3394b97a090866be11137aa
Autor:
Jui-Hua Hsieh, Ruili Huang, Ja-An Lin, Alexander Sedykh, Jinghua Zhao, Raymond R Tice, Richard S Paules, Menghang Xia, Scott S Auerbach
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177902 (2017)
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dep
Externí odkaz:
https://doaj.org/article/8b650d38ea7240319ec39f2d30d45c86
Autor:
Jui-Hua Hsieh, Ruili Huang, Ja-An Lin, Alexander Sedykh, Jinghua Zhao, Raymond R Tice, Richard S Paules, Menghang Xia, Scott S Auerbach
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181291 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0177902.].
Externí odkaz:
https://doaj.org/article/789e569b41a9423faff626bf9ef46955
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64779 (2013)
Deficiencies in the ATM gene are the underlying cause for ataxia telangiectasia, a syndrome characterized by neurological, motor and immunological defects, and a predisposition to cancer. MicroRNAs (miRNAs) are useful tools for cancer profiling and p
Externí odkaz:
https://doaj.org/article/b1e3e05b903a4ddc9bca707c8c3a3280
Autor:
Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S Paules, François Pognan, Frank Staedtler, Martin P Vidgeon-Hart, Olivier Grenet, Philippe Couttet
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40395 (2012)
Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff
Externí odkaz:
https://doaj.org/article/1bf1e6df5257478dabeac3b061a4a4f0
Autor:
William K. Kaufmann, Richard S. Paules, Pierre R. Bushel, Feng Cao, Dennis A. Simpson, Yingchun Zhou, Jeff Chou, Tong Zhou
Supplementary Table S1 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353f4819ae0809f91b0962b06ede00f0
https://doi.org/10.1158/1541-7786.22520628
https://doi.org/10.1158/1541-7786.22520628
Autor:
William K. Kaufmann, Richard S. Paules, Pierre R. Bushel, Feng Cao, Dennis A. Simpson, Yingchun Zhou, Jeff Chou, Tong Zhou
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4133a81999fac3e35ea2411300c02e01
https://doi.org/10.1158/1541-7786.c.6542700.v1
https://doi.org/10.1158/1541-7786.c.6542700.v1
Supplementary Figure Legends 1-3 from DNA Protein Kinase–Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe0bd1414df86a609e623627afce200
https://doi.org/10.1158/0008-5472.22371335.v1
https://doi.org/10.1158/0008-5472.22371335.v1