Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Richard S Judson"'
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0215906 (2019)
Many parameters treated as constants in traditional physiologically based pharmacokinetic models must be formulated as time-varying quantities when modeling pregnancy and gestation due to the dramatic physiological and anatomical changes that occur d
Externí odkaz:
https://doaj.org/article/bc4ce670caa848b3adefdb2dcb404470
Autor:
Eric D Watt, Richard S Judson
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0196963 (2018)
High throughput screening (HTS) projects like the U.S. Environmental Protection Agency's ToxCast program are required to address the large and rapidly increasing number of chemicals for which we have little to no toxicity measurements. Concentration-
Externí odkaz:
https://doaj.org/article/c9e466ef712141b4b12a6b168b23ef71
Autor:
Deepak Mav, Ruchir R Shah, Brian E Howard, Scott S Auerbach, Pierre R Bushel, Jennifer B Collins, David L Gerhold, Richard S Judson, Agnes L Karmaus, Elizabeth A Maull, Donna L Mendrick, B Alex Merrick, Nisha S Sipes, Daniel Svoboda, Richard S Paules
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191105 (2018)
Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses induced by exposures to chemicals, drugs and environment agents. The U.S. Tox21 Federal col
Externí odkaz:
https://doaj.org/article/ac4c3100313c431db2f048cc682fb4c1
Autor:
Imran Shah, Keith Houck, Richard S Judson, Robert J Kavlock, Matthew T Martin, David M Reif, John Wambaugh, David J Dix
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14584 (2011)
BackgroundNuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some NR is a non-genotoxic mechanism of rodent liver cancer with unclear relevance to h
Externí odkaz:
https://doaj.org/article/ed5c65908d7240b6ab1410db368238d9
Autor:
Kelly J Chandler, Marianne Barrier, Susan Jeffay, Harriette P Nichols, Nicole C Kleinstreuer, Amar V Singh, David M Reif, Nisha S Sipes, Richard S Judson, David J Dix, Robert Kavlock, Edward S Hunter, Thomas B Knudsen
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e18540 (2011)
The vast landscape of environmental chemicals has motivated the need for alternative methods to traditional whole-animal bioassays in toxicity testing. Embryonic stem (ES) cells provide an in vitro model of embryonic development and an alternative me
Externí odkaz:
https://doaj.org/article/5d5d41f27bda48b6a63e677cabf91696
Autor:
Katy N. Britton, Richard S. Judson, Bridgett N. Hill, Kimberly A. Jarema, Jeanene K. Olin, Bridget R. Knapp, Morgan Lowery, Madison Feshuk, Jason Brown, Stephanie Padilla
Publikováno v:
Toxics, Vol 12, Iss 7, p 501 (2024)
Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of
Externí odkaz:
https://doaj.org/article/2afc9cb4a3d84b40bb001ea05452da0e
Autor:
Richard S. Judson, Doris Smith, Michael DeVito, John F. Wambaugh, Barbara A. Wetmore, Katie Paul Friedman, Grace Patlewicz, Russell S. Thomas, Risa R. Sayre, Jennifer H. Olker, Sigmund Degitz, Stephanie Padilla, Joshua A. Harrill, Timothy Shafer, Kelly E. Carstens
Publikováno v:
Toxics, Vol 12, Iss 4, p 271 (2024)
Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, c
Externí odkaz:
https://doaj.org/article/65a7eaa4eb3848ff8e5cf8a509a96a88
Autor:
Imran Shah, Joseph Bundy, Bryant Chambers, Logan J. Everett, Derik Haggard, Joshua Harrill, Richard S. Judson, Johanna Nyffeler, Grace Patlewicz
Publikováno v:
Chemical Research in Toxicology. 35:1929-1949
Screening new compounds for potential bioactivities against cellular targets is vital for drug discovery and chemical safety. Transcriptomics offers an efficient approach for assessing global gene expression changes, but interpreting chemical mechani
Autor:
Thomas Sheffield, Richard S. Judson, Joseph Bundy, Clinton Willis, Imran Shah, Logan J. Everett, Joshua A. Harrill, Derik E. Haggard, Russell S. Thomas
Publikováno v:
Toxicol Sci
New approach methodologies (NAMs) that efficiently provide information about chemical hazard without using whole animals are needed to accelerate the pace of chemical risk assessments. Technological advancements in gene expression assays have made in
Autor:
Dustin F. Kapraun, Mark Sfeir, Robert G Pearce, Sarah E Davidson-Fritz, Annie Lumen, André Dallmann, Richard S Judson, John F. Wambaugh
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 113
Chemical risk assessment considers potentially susceptible populations including pregnant women and developing fetuses. Humans encounter thousands of chemicals in their environments, few of which have been fully characterized. Toxicokinetic (TK) info