Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Richard S Brush"'
Autor:
Yixiao Wang, Silke Becker, Stella Finkelstein, Frank M. Dyka, Haitao Liu, Mark Eminhizer, Ying Hao, Richard S. Brush, William J. Spencer, Vadim Y. Arshavsky, John D. Ash, Jianhai Du, Martin-Paul Agbaga, Frans Vinberg, Jessica M. Ellis, Ekaterina S. Lobanova
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The retina is light-sensitive neuronal tissue in the back of the eye. The phospholipid composition of the retina is unique and highly enriched in polyunsaturated fatty acids, including docosahexaenoic fatty acid (DHA). While it is generally
Externí odkaz:
https://doaj.org/article/ad85367e74fe4ef684827fbc22b57206
Autor:
Christian Schori, Martin-Paul Agbaga, Richard S Brush, Radha Ayyagari, Christian Grimm, Marijana Samardzija
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190514 (2018)
Mutations in the elongation of very long chain fatty acid 4 (ELOVL4) gene cause Stargardt macular dystrophy 3 (STGD3), a rare, juvenile-onset, autosomal dominant form of macular degeneration. Although several mouse models have already been generated
Externí odkaz:
https://doaj.org/article/e9d911507091450db9ea97b11325f88c
Autor:
Megan Stiles, Gennadiy P Moiseyev, Madeline L Budda, Annette Linens, Richard S Brush, Hui Qi, Gary L White, Roman F Wolf, Jian-Xing Ma, Robert Floyd, Robert E Anderson, Nawajes A Mandal
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145305 (2015)
A2E and related toxic molecules are part of lipofuscin found in the retinal pigment epithelial (RPE) cells in eyes affected by Stargardt's disease, age-related macular degeneration (AMD), and other retinal degenerations. A novel therapeutic approach
Externí odkaz:
https://doaj.org/article/2457b9cc2d0d45449de112715cd5b188
Autor:
Yeboah Kofi Gyening, Keren Boris, Mignot Cyril, Richard S. Brush, Marie-Cécile Nassogne, Martin-Paul Agbaga
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-10 (2023)
Abstract Spinocerebellar ataxia 34 (SCA34) is an autosomal dominant inherited disease characterized by age-related cerebellar degeneration and ataxia caused by mutations in the Elongation of Very Long Chain Fatty Acid-4 (ELOVL4) gene. The ELOVL4 enzy
Externí odkaz:
https://doaj.org/article/56bf065f1de443278b312bf8792439b0
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Autor:
Michael Landowski, Vijesh J. Bhute, Samuel Grindel, Zachary Haugstad, Yeboah K. Gyening, Madison Tytanic, Richard S. Brush, Lucas J. Moyer, David W. Nelson, Christopher R. Davis, Chi-Liang Eric Yen, Sakae Ikeda, Martin-Paul Agbaga, Akihiro Ikeda
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Lipid analysis of transmembrane protein 135 (TMEM135) mutant mice reveals robust decreases in docosahexaenoic acid (DHA), indicating a function of TMEM135 on the export of DHA from peroxisomes that is important for maintaining lipid metabolism.
Externí odkaz:
https://doaj.org/article/aac097ba34414892882b668cb0412247
Autor:
Alexandra Bernardo-Colón, Lijin Dong, Mones Abu-Asab, Richard S. Brush, Martin-Paul Agbaga, S. Patricia Becerra
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100358- (2023)
Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R) (also known as ATGL). PEDF-R exhibits phospholipase activity that mediates the neurotrophi
Externí odkaz:
https://doaj.org/article/e6edfbfcaeb9463cb8396dbeb2decb19
Autor:
Katarzyna Zyla-Jackson, Dorothy A. Walton, Kendra S. Plafker, Susan Kovats, Constantin Georgescu, Richard S. Brush, Madison Tytanic, Martin-Paul Agbaga, Scott M. Plafker
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionFive to eight percent of the world population currently suffers from at least one autoimmune disorder. Despite multiple immune modulatory therapies for autoimmune demyelinating diseases of the central nervous system, these treatments can
Externí odkaz:
https://doaj.org/article/277427e44b8545229135fd962009e462
Autor:
Yeboah Kofi Gyening, Neeraj Kumar Chauhan, Madison Tytanic, Vicki Ea, Richard S. Brush, Martin-Paul Agbaga
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 1, Pp 100317- (2023)
The FA Elongase-4 (ELOVL4) enzyme mediates biosynthesis of both very long chain (VLC)-PUFAs and VLC-saturated FA (VLC-SFAs). VLC-PUFAs play critical roles in retina and sperm function, whereas VLC-SFAs are predominantly associated with brain function
Externí odkaz:
https://doaj.org/article/837b278313024f33a618f388b91f0798
Autor:
Alena Golubkova, Tyler Leiva, Katherine Snyder, Camille Schlegel, Sarah M. Bonvicino, Martin-Paul Agbaga, Richard S. Brush, Jason M. Hansen, Peter F. Vitiello, Catherine J. Hunter
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1385 (2023)
Necrotizing enterocolitis (NEC) is a neonatal intestinal disease associated with oxidative stress. The targets of peroxidation and the role of the innate intestinal epithelial antioxidant defense system are ill-defined. We hypothesized that oxidative
Externí odkaz:
https://doaj.org/article/97d12cbb3ea24343bcbae3301010ee7b
Autor:
Martin-Paul Agbaga, Dana K. Merriman, Richard S. Brush, Todd A. Lydic, Shannon M. Conley, Muna I. Naash, Shelley Jackson, Amina S. Woods, Gavin E. Reid, Julia V. Busik, Robert E. Anderson
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1586-1596 (2018)
Long-chain PUFAs (LC-PUFAs; C20–C22; e.g., DHA and arachidonic acid) are highly enriched in vertebrate retina, where they are elongated to very-long-chain PUFAs (VLC-PUFAs; C ≥28) by the elongation of very-long-chain fatty acids-4 (ELOVL4) enzyme
Externí odkaz:
https://doaj.org/article/a20078d83b14410aaa6495dc9e364840